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. 1990 Jun;80(3):400–403. doi: 10.1111/j.1365-2249.1990.tb03300.x

HLA-DR, DQ and T cell antigen receptor constant beta genes in Japanese patients with ulcerative colitis.

K Kobayashi 1, M Atoh 1, Y Konoeda 1, A Yagita 1, H Inoko 1, S Sekiguchi 1
PMCID: PMC1535193  PMID: 1973647

Abstract

We studied the T cell antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (n = 17) but completely absent in the controls (n = 35) (chi2 = 47.6, P less than 0.001). The frequency of HLA-DR2 antigen was significantly higher in UC patients (85% versus 28% in controls, P less than 0.001). Furthermore, HLA-DQw1 antigen was also increased in UC patients (96% versus 60% in controls, P less than 0.001). However, HLA-DR4 antigen was significantly decreased in UC patients (12% versus 37%, P = 0.02). HLA-DR1 antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA-DQw1 antigen may be important in the pathogenesis of Japanese UC.

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Selected References

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