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. 1991 Feb;83(2):215–218. doi: 10.1111/j.1365-2249.1991.tb05617.x

Effect of macrophage-derived factor on hypoferraemia induced by Japanese encephalitis virus in mice.

M Bharadwaj 1, N Khanna 1, A Mathur 1, U C Chaturvedi 1
PMCID: PMC1535269  PMID: 1847096

Abstract

Depression of serum iron following Japanese encephalitis virus (JEV) infection was observed in mice. The hypoferraemia was associated with the accumulation of iron in reticulo-endothelial cells in the spleen. Splenectomy (compared with sham-operation) prevented the depression in serum iron concentration after JEV infection. It also prevented the rise in levels of liver iron. The effect of JEV-stimulated, splenic macrophage-derived factor (MDF) was evaluated in causing hypoferraemia. MDF produced a rapid reduction in the serum iron levels with accumulation of iron in spleen. These observations suggest that MDF plays a key role in the regulation of iron metabolism during JEV infection.

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Selected References

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