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. 1990 Dec;82(3):548–552. doi: 10.1111/j.1365-2249.1990.tb05488.x

Cytokine regulation of HLA on thyroid epithelial cells

K Migita, K Eguchi, T Otsubo, A Kawakami, H Nakao, Y Ueki, C Shimomura, A Kurata, T Fukuda, M Matsunaga, N Ishikawa, K Ito, S Nagataki
PMCID: PMC1535486  PMID: 2124959

Abstract

The regulation of class I and class II HLA expression in human thyroid follicular cells was studied in vitro. Tumour necrosis factor-alpha (TNF-α) enhanced the expression of class I antigen on thyrocytes, but these cytokines had little effect on the expression of class II antigen. Interleukin-1β (IL-1β) and interleukin-6 (IL-6) did not affect class I and class II antigen expression. The combination of interferon-gamma (IFN-γ) with TNF-α or IL-1β enhanced the induction of class I and class II antigens, compared with the effect of IFN-γ alone. Neither class I nor class II expression was induced by IL-6 alone or in combination with IFN-γ. These findings suggest that TNF-α and IL-1β may have an important role in inappropriate expression of HLA antigens on thyrocytes in thyroid gland.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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