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. 1990 Dec;82(3):553–558. doi: 10.1111/j.1365-2249.1990.tb05489.x

HLA class II glycoprotein expression by monocytes from HIV-infected individuals: differences in response to interferon-gamma.

B S Zwilling 1, R Darrow 1, M Mcpeek 1, H Laufman 1, D Pearl 1
PMCID: PMC1535493  PMID: 2124960

Abstract

The expression of HLA class II glycoproteins by monocytes from HIV-infected individuals was evaluated. We found no differences in HLA-DR, HLA-DQ, or HLA-DP expression by freshly isolated monocytes from patients with clinical AIDS, HIV-infected patients without AIDS or from uninfected individuals. However, monocytes from HIV-infected individuals without AIDS responded better to stimulation with recombinant human interferon-gamma (IFN-gamma) than did monocytes from patients with clinical AIDS or from uninfected individuals. The response to IFN-gamma stimulation by monocytes from patients with clinical AIDS was different. Thus, the largest increases in the percentage of cells expressing HLA-DR was associated with the smallest changes in the fluorescence intensity of the population that is observed following stimulation of monocytes from other patient populations.

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Selected References

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