Abstract
Male NZB/NZW F1 hybrid (B/W) mice survive their first year of life and die of lupus nephritis or lymphoid malignancy during the second year. Androgen therapy, even if delayed until 9 months of age, improves survival considerably. We report here that androgen therapy in aged B/W mice is associated with improved cell-mediated immune function as well as increased survival. Androgen treated mice have significantly augmented spleen cell responses to phytohaemagglutinin (PHA) and a decreased incidence of abnormal splenic suppressor activity. These results suggest that androgen may prolong survival in B/W mice in part through an effect on abnormally suppressive regulatory cells that impair T lymphocyte function.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Eidinger D., Garrett T. J. Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation. J Exp Med. 1972 Nov 1;136(5):1098–1116. doi: 10.1084/jem.136.5.1098. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Michalski J. P., McCombs C. C., Talal N. Suppressor cells and immunodeficiency in (NZB x NZW)F1 hybrid mice. Eur J Immunol. 1979 Jun;9(6):440–446. doi: 10.1002/eji.1830090605. [DOI] [PubMed] [Google Scholar]
- Michalski J. P., McCombs C. Decreased lymphocyte reactivity to a suboptimal concentration of phytohemagglutinin in Sjögren's syndrome. Arthritis Rheum. 1977 Apr;20(3):851–858. doi: 10.1002/art.1780200315. [DOI] [PubMed] [Google Scholar]
- Roder J. C., Bell D. A., Singhal S. K. Regulation of the immune response in autoimmune NZB/NZW F1 mice. I. The spontaneous generation of splenic suppressor cells. Cell Immunol. 1977 Mar 15;29(2):272–284. doi: 10.1016/0008-8749(77)90322-7. [DOI] [PubMed] [Google Scholar]
- Roder J. C., Bell D. A., Singhal S. K. T cell activation and cellular cooperation in autoimmune NZB/NZW F hybrid mice. J Immunol. 1975 Aug;115(2):466–472. [PubMed] [Google Scholar]
- Roubinian J. R., Papoian R., Talal N. Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest. 1977 Jun;59(6):1066–1070. doi: 10.1172/JCI108729. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Delayed androgen treatment prolongs survival in murine lupus. J Clin Invest. 1979 May;63(5):902–911. doi: 10.1172/JCI109390. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978 Jun 1;147(6):1568–1583. doi: 10.1084/jem.147.6.1568. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Talal N., Steinberg A. D. The pathogenesis of autoimmunity in New Zealand black mice. Curr Top Microbiol Immunol. 1974;64(0):79–103. doi: 10.1007/978-3-642-65848-8_3. [DOI] [PubMed] [Google Scholar]