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. 1983 Sep;53(3):739–743.

Increased expression of human monocyte HLA-DR antigens and Fc gamma receptors in response to human interferon in vivo.

J Rhodes, D H Jones, N M Bleehen
PMCID: PMC1535636  PMID: 6311468

Abstract

The expression of class II MHC encoded antigens (HLA-DR) and Fc gamma receptors by peripheral blood monocytes from untreated patients with small cell carcinoma of the bronchus was compared with that of normal donors. Fc gamma receptor expression was found to be elevated in these patients in comparison with normal. In contrast HLA-DR antigen expression by patients' monocytes was somewhat depressed in comparison with normal. Continuous intravenous infusion of a total of 400 megaunits/m2 of human lymphoblastoid interferon-alpha (IFN-alpha) over a 5 day period markedly increased both monocyte HLA-DR antigen expression and Fc gamma receptor expression in comparison with that of untreated patients and normal donors. The initial increases declined somewhat but were still evident after 3 weeks of intermittent intramuscular IFN-alpha therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abb J., Abb H., Deinhardt F. Effect of retinoic acid on the spontaneous and interferon-induced activity of human natural killer cells. Int J Cancer. 1982 Sep 15;30(3):307–310. doi: 10.1002/ijc.2910300309. [DOI] [PubMed] [Google Scholar]
  2. Baron S., Kleyn K. M., Russell J. K., Blalock J. E. Retinoic acid: enhancement of a tumor and inhibition of interferon's antitumor action. J Natl Cancer Inst. 1981 Jul;67(1):95–97. [PubMed] [Google Scholar]
  3. Brickell P. M., McConnell I., Milstein C., Wright B. A monoclonal antibody to the HLA-DR product recognizes a polymorphic Ia determinant in mice. Immunology. 1981 Jul;43(3):493–501. [PMC free article] [PubMed] [Google Scholar]
  4. Coombs R. R., Wilson A. B., Eremin O., Gurner B. W., Haegert D. G., Lawson Y. A., Bright S., Munro A. J. Comparison of the direct antiglobulin rosetting reaction with the mixed antiglobulin rosetting reaction for the detection of immunoglobulin on lymphocytes. J Immunol Methods. 1977;18(1-2):45–54. doi: 10.1016/0022-1759(77)90157-0. [DOI] [PubMed] [Google Scholar]
  5. Einhorn S., Jarstrand C. Decrease in the phagocytic activity of peripheral monocytes in patients treated with human interferon-alpha. Cancer Immunol Immunother. 1982;13(3):149–152. doi: 10.1007/BF00205379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fellous M., Kamoun M., Gresser I., Bono R. Enhanced expression of HLA antigens and beta 2-microglobulin on interferon-treated human lymphoid cells. Eur J Immunol. 1979 Jun;9(6):446–449. doi: 10.1002/eji.1830090606. [DOI] [PubMed] [Google Scholar]
  7. Fridman W. H., Gresser I., Bandu M. T., Aguet M., Neauport-Sautes C. Interferon enhances the expression of Fc gamma receptors. J Immunol. 1980 May;124(5):2436–2441. [PubMed] [Google Scholar]
  8. Hamburg S. I., Manejias R. E., Rabinovitch M. Macrophage activation: increased ingestion of IgG-coated erythrocytes after administration of interferon inducers to mice. J Exp Med. 1978 Feb 1;147(2):593–598. doi: 10.1084/jem.147.2.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Itoh K., Inoue M., Kataoka S., Kumagai K. Differential effect of interferon expression of IgG- and IgM-Fc receptors on human lymphocytes. J Immunol. 1980 Jun;124(6):2589–2595. [PubMed] [Google Scholar]
  10. Jones D. H., Bleehen N. M., Slater A. J., George P. J., Walker J. R., Dixon A. K. Human lymphoblastoid interferon in the treatment of small cell lung cancer. Br J Cancer. 1983 Mar;47(3):361–366. doi: 10.1038/bjc.1983.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lindahl P., Gresser I., Leary P., Tovey M. Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1284–1287. doi: 10.1073/pnas.73.4.1284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lucero M. A., Magdelenat H., Fridman W. H., Pouillart P., Billardon C., Billiau A., Cantell K., Falcoff E. Comparison of effects of leukocyte and fibroblast interferon on immunological parameters in cancer patients. Eur J Cancer Clin Oncol. 1982 Mar;18(3):243–251. doi: 10.1016/0277-5379(82)90043-8. [DOI] [PubMed] [Google Scholar]
  13. Matsubara S., Suzuki M., Ishida N. Impaired induction of type II interferon in tumor-bearing mice. Cancer Res. 1980 Mar;40(3):873–876. [PubMed] [Google Scholar]
  14. Matsubara S., Suzuki M., Nakamura M., Edo K., Ishida N. Isolation of an inhibitor of type II interferon induction from tumor ascitic fluids. Cancer Res. 1980 Jul;40(7):2534–2538. [PubMed] [Google Scholar]
  15. Rhodes J. Altered expression of human monocyte Fc receptors in malignant disease. Nature. 1977 Jan 20;265(5591):253–255. doi: 10.1038/265253a0. [DOI] [PubMed] [Google Scholar]
  16. Rhodes J., Bishop M., Benfield J. Tumor surveillance: how tumors may resist macrophage-mediated host defense. Science. 1979 Jan 12;203(4376):179–182. doi: 10.1126/science.758686. [DOI] [PubMed] [Google Scholar]
  17. Rhodes J., Stokes P. Interferon-induced changes in the monocyte membrane: inhibition by retinol and retinoic acid. Immunology. 1982 Mar;45(3):531–536. [PMC free article] [PubMed] [Google Scholar]
  18. Ruco L. P., Procopio A., Uccini S., Baroni C. D. Increased monocyte phagocytosis in cancer patients. Eur J Cancer. 1980 Oct;16(10):1315–1320. doi: 10.1016/0014-2964(80)90288-1. [DOI] [PubMed] [Google Scholar]
  19. Snyder D. S., Beller D. I., Unanue E. R. Prostaglandins modulate macrophage Ia expression. Nature. 1982 Sep 9;299(5879):163–165. doi: 10.1038/299163a0. [DOI] [PubMed] [Google Scholar]

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