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. 1983 Sep;53(3):547–554.

Murine lupus nephritis: effect of azathioprine on glomerular permeability and localization of immunoreactants.

T Cavallo, K Graves, N A Granholm
PMCID: PMC1535649  PMID: 6616955

Abstract

We investigated the effect of azathioprine on glomerular permeability and deposition of immunoreactants in NZB/W mice. Glomerular permeability, assessed by proteins excreted in the urine and by a molecular probe of anionic sites of the basement membrane, underwent negligible changes, in comparison to pre-treatment findings, and deposits of immunoreactants were largely mesangial and were decreased overall. Therapy with azathioprine preserved glomerular structure and function by decreasing the amount of immunoreactants, by inducing a preferential mesangial localization of immunoreactants, and, possibly, by interfering with factors that favor the deposition of immunoreactants in the glomerular capillary wall.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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