Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1983 Sep;53(3):689–696.

IgM and IgD concentrations in the serum and secretions of children with selective IgA deficiency.

A Plebani, E Mira, E Mevio, V Monafo, L D Notarangelo, A Avanzini, A G Ugazio
PMCID: PMC1535652  PMID: 6616961

Abstract

Serum IgG and serum and secretory IgM, IgA and IgD levels were determined in 14 children with selective IgA deficiency and in 12 age and sex matched healthy controls. IgD was determined using a highly sensitive ELISA technique. In the healthy controls serum IgG, IgA and IgM were all in the age normal range, and serum IgA was significantly higher than secretory IgA with IgA in nasal secretions being significantly higher than in saliva. In the IgA deficient children serum IgG and IgM and secretory IgM were present in higher concentrations than in the controls but the difference was statistically significant only for serum IgG and salivary IgM. IgD was detectable in the serum and secretions of all patients and all but one control subject. Like IgM, serum IgD levels were significantly higher than secretory IgD levels and IgD was present in greater concentrations in nasal secretions than in saliva both in the patients and the controls, with no difference between the two groups. Thus, the data of this study show that while serum and secretory IgM levels are elevated in children with selective IgA deficiency, serum and secretory IgD are present in normal concentrations, supporting the hypothesis of a compensatory increase in IgM but not in IgD in such patients.

Full text

PDF
689

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ammann A. J., Hong R. Selective IgA deficiency: presentation of 30 cases and a review of the literature. Medicine (Baltimore) 1971 May;50(3):223–236. [PubMed] [Google Scholar]
  2. Berglund G., Finnström O., Johansson S. G., Möller K. L. Wiskott-Aldrich syndrome. A study of 6 cases with determination of the immunoglobulins A, D, G, M and ND. Acta Paediatr Scand. 1968 Mar;57(2):89–97. doi: 10.1111/j.1651-2227.1968.tb04658.x. [DOI] [PubMed] [Google Scholar]
  3. Brandtzaeg P., Gjeruldsen S. T., Korsrud F., Baklien K., Berdal P., Ek J. The human secretory immune system shows striking heterogeneity with regard to involvement of J chain-positive IgD immunocytes. J Immunol. 1979 Feb;122(2):503–510. [PubMed] [Google Scholar]
  4. Brandtzaeg P. Human secretory immunoglobulin M. An immunochemical and immunohistochemical study. Immunology. 1975 Sep;29(3):559–570. [PMC free article] [PubMed] [Google Scholar]
  5. Brandtzaeg P. Human secretory immunoglobulins. II. Salivary secretions from individuals with selectively excessive or defective synthesis of serum immunoglobulins. Clin Exp Immunol. 1971 Jan;8(1):69–85. [PMC free article] [PubMed] [Google Scholar]
  6. Buckley R. H., Fiscus S. A. Serum IgD and IgE concentrations in immunodeficiency diseases. J Clin Invest. 1975 Jan;55(1):157–165. doi: 10.1172/JCI107906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Burgio G. R., Lanzavecchia A., Plebani A., Jayakar S., Ugazio A. G. Ontogeny of secretory immunity: levels of secretory IgA and natural antibodies in saliva. Pediatr Res. 1980 Oct;14(10):1111–1114. doi: 10.1203/00006450-198010000-00004. [DOI] [PubMed] [Google Scholar]
  8. Crabbé P. A., Bazin H., Eyssen H., Heremans J. F. The normal microbial flora as a major stimulus for proliferation of plasma cells synthesizing IgA in the gut. The germ-free intestinal tract. Int Arch Allergy Appl Immunol. 1968;34(4):362–375. doi: 10.1159/000230130. [DOI] [PubMed] [Google Scholar]
  9. Devey M., Sanderson C. J., Carter D., Coombs R. R. IgD antibody to insuin. Lancet. 1970 Dec 19;2(7686):1280–1283. doi: 10.1016/s0140-6736(70)92243-9. [DOI] [PubMed] [Google Scholar]
  10. Dunnette S. L., Gleich G. J., Miller R. D., Kyle R. A. Measurement of IgD by a double antibody radioimmunoassay: demonstration of an apparent trimodal distribution of IgD levels in normal human sera. J Immunol. 1977 Nov;119(5):1727–1731. [PubMed] [Google Scholar]
  11. Henney C. S., Welscher H. D., Terry W. D., Rowe D. S. Studies on human IgD. II. The lack of skin sensitizing and complement fixing activities of immunoglobulin D. Immunochemistry. 1969 May;6(3):445–449. [PubMed] [Google Scholar]
  12. Horowitz S., Hong R. Selective IgA deficiency---some perspectives. Birth Defects Orig Artic Ser. 1975;11(1):129–133. [PubMed] [Google Scholar]
  13. Hughes E. C., Johnson R. L. Circadian and interpersonal variability of IgA in nasal secretions. Ann Otol Rhinol Laryngol. 1973 Mar-Apr;82(2):216–222. doi: 10.1177/000348947308200221. [DOI] [PubMed] [Google Scholar]
  14. Johansson S. G., Högman C. F., Killander J. Quantitative immunoglobulin determination. Comparison of two methods. Estimation of normal levels and levels in persons lacking IgA and IgD. Acta Pathol Microbiol Scand. 1968;74(4):519–530. [PubMed] [Google Scholar]
  15. Josephs S. H., Buckley R. H. Serum IgD concentrations in normal infants, children, and adults and in patients with elevated IgE. J Pediatr. 1980 Mar;96(3 Pt 1):417–420. doi: 10.1016/s0022-3476(80)80684-6. [DOI] [PubMed] [Google Scholar]
  16. Kantor G. L., Van Herle A. J., Barnett E. V. Auto-antibodies of the IgD class. Clin Exp Immunol. 1970 Jun;6(6):951–962. [PMC free article] [PubMed] [Google Scholar]
  17. Leslie G. A., Teramura G. Structure and biological functions of human IgD. XIV. The development of a solid-phase radioimmunoassay for the quantitation of IgD in human sera and secretions. Int Arch Allergy Appl Immunol. 1977;54(5):451–456. [PubMed] [Google Scholar]
  18. Luster M. I., Armen R. C., Hallum J. V., Leslie G. A. Measles virus-specific IgD antibodies in patients with subacute sclerosing panencephalitis. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1297–1299. doi: 10.1073/pnas.73.4.1297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  20. Mygind N., Weeke B., Ullman S. Quantitative determination of immunoglobulins in nasal secretion. Int Arch Allergy Appl Immunol. 1975;49(1-2):99–107. doi: 10.1159/000231383. [DOI] [PubMed] [Google Scholar]
  21. Ovary Z. Lack of skin-sensitizing property of gamma D myeloma protein in guinea pigs. J Immunol. 1969 Mar;102(3):790–791. [PubMed] [Google Scholar]
  22. Oxelius V. A., Laurell A. B., Lindquist B., Golebiowska H., Axelsson U., Björkander J., Hanson L. A. IgG subclasses in selective IgA deficiency: importance of IgG2-IgA deficiency. N Engl J Med. 1981 Jun 11;304(24):1476–1477. doi: 10.1056/NEJM198106113042408. [DOI] [PubMed] [Google Scholar]
  23. ROWE D. S., FAHEY J. L. A NEW CLASS OF HUMAN IMMUNOGLOBULINS. I. A UNIQUE MYELOMA PROTEIN. J Exp Med. 1965 Jan 1;121:171–184. doi: 10.1084/jem.121.1.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. ROWE D. S., FAHEY J. L. A NEW CLASS OF HUMAN IMMUNOGLOBULINS. II. NORMAL SERUM IGD. J Exp Med. 1965 Jan 1;121:185–199. doi: 10.1084/jem.121.1.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Rogentine G. N., Jr, Rowe D. S., Bradley J., Waldmann T. A., Fahey J. L. Metabolism of human immunoglobulin D (IgD). J Clin Invest. 1966 Sep;45(9):1467–1478. doi: 10.1172/JCI105454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Rowe D. S., Crabbé P. A., Turner M. W. Immunoglobulin D in serum, body fluids and lymphoid tissues. Clin Exp Immunol. 1968 Jul;3(6):477–490. [PMC free article] [PubMed] [Google Scholar]
  27. Rowe D. S., Hug K., Faulk W. P., McCormick J. N., Gerber H. IgD on the surface of peripheral blood lymphocytes of the human newborn. Nat New Biol. 1973 Apr 4;242(118):155–157. doi: 10.1038/newbio242155a0. [DOI] [PubMed] [Google Scholar]
  28. Savilahti E. IgA deficiency in children. Immunoglobulin-containing cells in the intestinal mucosa, immunoglobulins in secretions and serum IgA levels. Clin Exp Immunol. 1973 Mar;13(3):395–406. [PMC free article] [PubMed] [Google Scholar]
  29. Sewell H. F., Chambers L., Maxwell V., Matthews J. B., Jefferis R. The natural antibody response to E. coli includes antibodies of the IgD class. Clin Exp Immunol. 1978 Jan;31(1):104–110. [PMC free article] [PubMed] [Google Scholar]
  30. Sewell H. F., Matthews J. B., Flack V., Jefferis R. Human immunoglobulin D in colostrum, saliva and amniotic fluid. Clin Exp Immunol. 1979 Apr;36(1):183–188. [PMC free article] [PubMed] [Google Scholar]
  31. Tomasi T. B., Grey H. M. Structure and function of immunoglobulin A. Prog Allergy. 1972;16:81–213. [PubMed] [Google Scholar]
  32. Van Boxel J. A., Paul W. E., Terry W. D., Green I. Communications. IgD-bearing human lymphocytes. J Immunol. 1972 Sep;109(3):648–651. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES