Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1983 Aug;53(2):297–307.

Defective in vitro antibody production to Varicella zoster and other virus antigens in patients with Hodgkin's disease.

R L Souhami, J Babbage, A Sigfusson
PMCID: PMC1535670  PMID: 6309443

Abstract

Cultures of blood mononuclear cells stimulated with Varicella zoster antigen (VZA) produced specific anti-VZA antibody in 20 of 27 normal adults but only 10 of 47 patients with treated Hodgkin's disease. Serum anti-VZA antibody levels were the same in normals and patients. The deficiency of in vitro production was found in patients who had been off treatment for 6 or more years and was not related to splenectomy. Each of 11 untreated patients had absent in vitro production from blood cells but spleen cultures produced antibody readily. Using combinations of autologous spleen and blood cells, the defect was attributable to the blood B cells. Defective production was also found in response to influenza viruses and herpes simplex. We suggest that an abnormality in B cell circulation with localization of antibody producing B cells in spleen and lymph nodes, is a feature of treated and untreated Hodgkin's disease.

Full text

PDF
297

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bobrove A. M., Fuks Z., Strober S., Kaplan H. S. Quantitation of T and B lymphocytes and cellular immune function in Hodgkin's disease. Cancer. 1975 Jul;36(1):169–179. doi: 10.1002/1097-0142(197507)36:1<169::aid-cncr2820360115>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  2. Callard R. E. Specific in vitro antibody response to influenza virus by human blood lymphocytes. Nature. 1979 Dec 13;282(5740):734–736. doi: 10.1038/282734a0. [DOI] [PubMed] [Google Scholar]
  3. Eltringham J. R., Kaplan H. S. Impaired delayed-hypersensitivity responses in 154 patients with untreated Hodgkin's disease. Natl Cancer Inst Monogr. 1973 May;36:107–115. [PubMed] [Google Scholar]
  4. Fauci A. S., Pratt K. R., Whalen G. Activation of human B lymphocytes. IV. Regulatory effects of corticosteroids on the triggering signal in the plaque-forming cell response of human peripheral blood B lymphocytes to polyclonal activation. J Immunol. 1977 Aug;119(2):598–603. [PubMed] [Google Scholar]
  5. Fuks Z., Strober S., Bobrove A. M., Sasazuki T., McMichael A., Kaplan H. S. Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease. J Clin Invest. 1976 Oct;58(4):803–814. doi: 10.1172/JCI108532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goffinet D. R., Glatstein E. J., Merigan T. C. Herpes Zoster-Varicella infections and lymphoma. Ann Intern Med. 1972 Feb;76(2):235–240. doi: 10.7326/0003-4819-76-2-235. [DOI] [PubMed] [Google Scholar]
  7. Holm G., Björkholm M., Johansson B., Mellstedt H., Lindemalm C. Monocyte function in Hodgkin's disease. Clin Exp Immunol. 1982 Jan;47(1):162–168. [PMC free article] [PubMed] [Google Scholar]
  8. Levy R., Kaplan H. S. Impaired lymphocyte function in untreated Hodgkin's disease. N Engl J Med. 1974 Jan 24;290(4):181–186. doi: 10.1056/NEJM197401242900402. [DOI] [PubMed] [Google Scholar]
  9. Ling N. R., Bishop S., Jefferis Use of antibody-coated red cells for the sensitive detection of antigen and in rosette tests for cells bearing surface immunoglobulins. J Immunol Methods. 1977;15(3):279–289. doi: 10.1016/0022-1759(77)90065-5. [DOI] [PubMed] [Google Scholar]
  10. Longmire R. L., McMillan R., Yelenosky R., Armstrong S., Lang J. E., Craddock C. G. In vitro splenic IgG synthesis in Hodgkin's disease. N Engl J Med. 1973 Oct 11;289(15):763–767. doi: 10.1056/NEJM197310112891501. [DOI] [PubMed] [Google Scholar]
  11. Ruckdeschel J. C., Schimpff S. C., Smyth A. C., Mardiney M. R., Jr Herpes zoster and impaired cell-associated immunity to the varicella-zoster virus in patients with Hodgkin's disease. Am J Med. 1977 Jan;62(1):77–85. doi: 10.1016/0002-9343(77)90352-7. [DOI] [PubMed] [Google Scholar]
  12. Santoro A., Cailou B., Belpomme D. T and B lymphocytes and monocytes in the spleen in Hodgkin's disease: the increase in T lymphocytes in involved spleens. Eur J Cancer. 1977 Apr-May;13(4-5):355–359. doi: 10.1016/0014-2964(77)90081-0. [DOI] [PubMed] [Google Scholar]
  13. Souhami R. L., Babbage J., Callard R. E. Specific in vitro antibody response to varicella zoster. Clin Exp Immunol. 1981 Oct;46(1):98–105. [PMC free article] [PubMed] [Google Scholar]
  14. Sousa M. D., Yang M., Lopes-Corrales E., Tan C., Hansen J. A., Dupont B., Good R. A. Ecotaxis: the principle and its application to the study of Hodgkin's disease. Clin Exp Immunol. 1977 Jan;27(1):143–151. [PMC free article] [PubMed] [Google Scholar]
  15. Twomey J. J., Laughter A. H., Rice L., Ford R. Spectrum of immunodeficiencies with Hodgkin's disease. J Clin Invest. 1980 Oct;66(4):629–637. doi: 10.1172/JCI109898. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES