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. 1983 Aug;53(2):281–288.

Relationship between T cell subsets and suppressor cell activity in chronic hepatitis B virus (HBV) infection.

V Barnaba, A Musca, C Cordova, M Levrero, G Ruocco, V Albertini-Petroni, F Balsano
PMCID: PMC1535673  PMID: 6224609

Abstract

The relationship between T cell subset, as defined by monoclonal antibodies, and suppressor cell function, using a short lived suppressor cell assay, was studied in 38 chronic hepatitis B virus (HBV) carriers and in 32 patients with HBsAg negative chronic active hepatitis (CAH). Patients with HBV chronic infection showed an absolute reduction in the OKT4 positive subset and a significantly decreased OKT4/OKT8 ratio, as compared with healthy controls. Patients with anti-nuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA) positive CAH with or without antibodies to HBV antigens, namely anti-HBs and anti-HBc, demonstrated a significant reduction in cytotoxic/suppressor T cells and an increased helper/suppressor ratio. A negative correlation between suppressor index (SI) and OKT4/OKT8 ratio (P less than 0.01), and a positive correlation between SI and OKT8 positive cells absolute number (P less than 0.01) were also observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alberti A., Realdi G., Bortolotti F., Rigoli A. M. T-lymphocyte cytotoxicity to HBsAg-coated target cells in hepatitis b virus infection. Gut. 1977 Dec;18(12):1004–1009. doi: 10.1136/gut.18.12.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barnaba V., Zaccari C., Levrero M., Ruocco G., Balsano F. Immunoregulatory T cells in HBV-induced chronic liver disease as defined by monoclonal antibodies. Clin Immunol Immunopathol. 1983 Jan;26(1):83–90. doi: 10.1016/0090-1229(83)90176-9. [DOI] [PubMed] [Google Scholar]
  3. Bresnihan B., Jasin H. E. Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J Clin Invest. 1977 Jan;59(1):106–116. doi: 10.1172/JCI108607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chisari F. V., Castle K. L., Xavier C., Anderson D. S. Functional properties of lymphocyte subpopulations in hepatitis B virus infection. I. Suppressor cell control of T lymphocyte responsiveness. J Immunol. 1981 Jan;126(1):38–44. [PubMed] [Google Scholar]
  5. Coovadia H. M., MacKay I. R., d'Apice A. J. Suppressor cells assayed by three different methods in patients with chronic active hepatitis and systemic lupus erythematosus. Clin Immunol Immunopathol. 1981 Feb;18(2):268–275. doi: 10.1016/0090-1229(81)90033-7. [DOI] [PubMed] [Google Scholar]
  6. Hadziyannis S., Moussouros A., Vissoulis C., Afroudakis A. Cytoplasmic localisation of Australia antigen in the liver. Lancet. 1972 May 6;1(7758):976–979. doi: 10.1016/s0140-6736(72)91153-1. [DOI] [PubMed] [Google Scholar]
  7. Kakumu S., Yata K., Kashio T. Immunoregulatory T-cell function in acute and chronic liver disease. Gastroenterology. 1980 Oct;79(4):613–619. [PubMed] [Google Scholar]
  8. Kerlin P., Nies K. M., Tong M. J. Unimpaired B-cell function and T-cell regulation of immunoglobulin synthesis in patients with chronic hepatitis B virus infection. Clin Immunol Immunopathol. 1982 Nov;25(2):149–156. doi: 10.1016/0090-1229(82)90177-5. [DOI] [PubMed] [Google Scholar]
  9. Mogensen C. E. The glomerular permeability determined by dextran clearance using Sephadex gel filtration. Scand J Clin Lab Invest. 1968;21(1):77–82. doi: 10.3109/00365516809076979. [DOI] [PubMed] [Google Scholar]
  10. Reinherz E. L., Rubinstein A., Geha R. S., Strelkauskas A. J., Rosen F. S., Schlossman S. F. Abnormalities of immunoregulatory T cells in disorders of immune function. N Engl J Med. 1979 Nov 8;301(19):1018–1022. doi: 10.1056/NEJM197911083011902. [DOI] [PubMed] [Google Scholar]
  11. Thomas H. C. T cell subsets in patients with acute and chronic HBV infection, primary biliary cirrhosis and alcohol induced liver disease. Int J Immunopharmacol. 1981;3(3):301–305. doi: 10.1016/0192-0561(81)90023-0. [DOI] [PubMed] [Google Scholar]
  12. Tremolada F., Fattovich G., Panebianco G., Ongaro G., Realdi G. Suppressor cell activity in viral and non-viral chronic active hepatitis. Clin Exp Immunol. 1980 Apr;40(1):89–95. [PMC free article] [PubMed] [Google Scholar]
  13. de Galocsy C., Jenkins P. J., Mieli-Vergani G., Eddleston A. L., Williams R. Increased sensitivity to concanavalin A and a suppressor cell defect in chronic active hepatitis. Clin Exp Immunol. 1981 Mar;43(3):486–490. [PMC free article] [PubMed] [Google Scholar]

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