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. 1984 Jan;55(1):36–40.

Liver cell surface expression of the antigen reacting with liver-kidney microsomal antibody (LKM).

M Lenzi, F B Bianchi, F Cassani, E Pisi
PMCID: PMC1535786  PMID: 6692597

Abstract

To test the hypothesis that liver membrane antibodies, found in all liver-kidney microsomal antibody (LKM) positive sera from patients with chronic active hepatitis, were directed against antigens shared by both hepatocellular endoplasmic reticulum and plasma membranes, absorption experiments have been performed using viable isolated hepatocytes and liver microsomes as antigens. Results are in agreement with the above hypothesis, LKM, which displays a restricted organ specificity, is thus able to react with antigenic determinants expressed on the liver cell surface, as it has been demonstrated for strictly organ specific antibodies directed against thyroid, adrenal and gastric parietal cell microsomes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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