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. 1984 Jan;55(1):74–80.

HLA-B27 and the immune response to enterobacterial antigens in ankylosing spondylitis.

A Trull, A Ebringer, G Panayi, R Ebringer, D C James
PMCID: PMC1535792  PMID: 6607143

Abstract

Total serum immunoglobulins and class specific serum antibodies to Klebsiella pneumoniae, Salmonella typhimurium, Yersinia enterocolitica and Pseudomonas aeruginosa were measured in 107 patients with ankylosing spondylitis (AS) and 110 healthy tissue typed controls by enzyme linked immunosorbent assay (ELISA). The specificity of this technique was confirmed by the use of specific bacterial murine antisera and by cross-absorption of human sera by specific bacteria. Total serum IgA in AS patients correlated with both erythrocyte sedimentation rate (ESR) (P less than 0.001) and C-reactive protein (P less than 0.05) and was significantly elevated compared to healthy individuals (P less than 0.001). A significant elevation of IgA antibodies to K. pneumoniae was detected in the serum of AS patients with active disease when compared to healthy controls (P less than 0.01). These studies support the involvement of an enterobacterial micro-organism in the pathogenesis of AS and further relate to the role of HLA-B27 in this disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aho K., Ahvonen P., Lassus A., Sievers K., Tiilikainen A. HL-A 27 in reactive arthritis. A study of Yersinia arthritis and Reiter's disease. Arthritis Rheum. 1974 Sep-Oct;17(5):521–526. doi: 10.1002/art.1780170505. [DOI] [PubMed] [Google Scholar]
  2. Avakian H., Welsh J., Ebringer A., Entwistle C. C. Ankylosing spondylitis, HLA-B27 and Klebsiella. II. Cross-reactivity studies with human tissue typing sera. Br J Exp Pathol. 1980 Feb;61(1):92–96. [PMC free article] [PubMed] [Google Scholar]
  3. Brewerton D. A., Hart F. D., Nicholls A., Caffrey M., James D. C., Sturrock R. D. Ankylosing spondylitis and HL-A 27. Lancet. 1973 Apr 28;1(7809):904–907. doi: 10.1016/s0140-6736(73)91360-3. [DOI] [PubMed] [Google Scholar]
  4. Caffrey M. F., James D. C. Human lymphocyte antigen association in ankylosing spondylitis. Nature. 1973 Mar 9;242(5393):121–121. doi: 10.1038/242121a0. [DOI] [PubMed] [Google Scholar]
  5. Calguneri M., Swinburne L., Shinebaum R., Cooke E. M., Wright V. Secretory IgA: immune defence pattern in ankylosing spondylitis and klebsiella. Ann Rheum Dis. 1981 Dec;40(6):600–604. doi: 10.1136/ard.40.6.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cowling P., Ebringer R., Cawdell D., Ishii M., Ebringer A. C-reactive protein, ESR, and klebsiella in ankylosing spondylitis. Ann Rheum Dis. 1980 Feb;39(1):45–49. doi: 10.1136/ard.39.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cowling P., Ebringer R., Ebringer A. Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis. 1980 Dec;39(6):545–549. doi: 10.1136/ard.39.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Eastmond C. J., Calguner M., Shinebaum R., Cooke E. M., Wright V. A sequential study of the relationship between faecal Klebsiella aerogenes and the common clinical manifestations of ankylosing spondylitis. Ann Rheum Dis. 1982 Feb;41(1):15–20. doi: 10.1136/ard.41.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ebringer A. The cross tolerance hypothesis in IR-gene systems, rheumatic fever and ankylosing spondylitis. Riv Biol. 1982 Summer;75(2):197–229. [PubMed] [Google Scholar]
  10. Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Granfors K., Viljanen M., Tiilikainen A., Toivanen A. Persistence of IgM, IgG, and IgA antibodies to Yersinia in yersinia arthritis. J Infect Dis. 1980 Apr;141(4):424–429. doi: 10.1093/infdis/141.4.424. [DOI] [PubMed] [Google Scholar]
  12. Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973 Apr 5;288(14):704–706. doi: 10.1056/NEJM197304052881403. [DOI] [PubMed] [Google Scholar]
  13. Trull A. K., Ebringer R., Panayi G. S., Colthorpe D., James D. C., Ebringer A. IgA antibodies to Klebsiella pneumoniae in ankylosing spondylitis. Scand J Rheumatol. 1983;12(3):249–253. doi: 10.3109/03009748309098543. [DOI] [PubMed] [Google Scholar]

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