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. 1984 Feb;55(2):413–418.

Isotype of lytic antibodies in serum of Chagas' disease patients.

S A Romeiro, H A Takehara, I Mota
PMCID: PMC1535813  PMID: 6421519

Abstract

The isotype of anti-Trypanosoma cruzi lytic antibodies present in sera obtained from patients with the chronic phase of Chagas' disease was determined. Serum samples were submitted to gel filtration in Sephacryl S-200, ion exchange chromatography in DEAE-cellulose, affinity chromatography with protein A and immunoadsorption with anti-human IgG-Sepharose. The results of these experiments showed that human anti-T. cruzi lytic antibodies are mainly located in the IgG isotype probably in the IgG1 and IgG2 subclasses.

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Selected References

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