Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1983 May;52(2):333–340.

IgG rheumatoid factors and anti-nuclear antibodies in rheumatoid vasculitis.

F P Quismorio, T Beardmore, R L Kaufman, E S Mongan
PMCID: PMC1535841  PMID: 6602676

Abstract

We studied the distribution and characteristics of circulating rheumatoid factors (RF) and anti-nuclear antibodies (ANA) in 30 rheumatoid arthritis (RA) patients who had polyarthritis alone (group I), 28 RA patients with polyarthritis and extra-articular disease (group II), 28 RA patients with systemic vasculitis (group III) and 60 healthy matched controls. IgG RF occurred more frequently and in higher serum titres in group III (100%) than RA patients in group I (40%), or in group II (18%) or in normal controls (5.8%). The serum titre of IgM RF was higher in vasculitis patients than in other RA patients. ANA were found in 74% of all RA patients and although the frequency did not differ in the three patient groups, the serum titre was significantly higher in the vasculitis group. Antibodies to extractable nuclear antigen were found only in group III (18.7%). Antibodies to histones were also more prevalent in group III than in the other RA groups. The serological abnormalities in rheumatoid vasculitis differed quantitatively as well as qualitatively from other RA patients.

Full text

PDF
333

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aitcheson C. T., Peebles C., Joslin F., Tan E. M. Characteristics of antinuclear antibodies in rheumatoid arthritis. Reactivity of rheumatoid factor with a histone-dependent nuclear antigen. Arthritis Rheum. 1980 May;23(5):528–538. doi: 10.1002/art.1780230503. [DOI] [PubMed] [Google Scholar]
  2. Allen C., Elson C. J., Scott D. G., Bacon P. A., Bucknall R. C. IgG antiglobulins in rheumatoid arthritis and other arthritides: relationship with clinical features and other parameters. Ann Rheum Dis. 1981 Apr;40(2):127–131. doi: 10.1136/ard.40.2.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carson D. A., Bayer A. S., Eisenberg R. A., Lawrance S., Theofilopoulos A. IgG rheumatoid factor in subacute bacterial endocarditis: relationship to IgM rheumatoid factor and circulating immune complexes. Clin Exp Immunol. 1978 Jan;31(1):100–103. [PMC free article] [PubMed] [Google Scholar]
  4. Carson D. A., Lawrance S., Catalano M. A., Vaughan J. H., Abraham G. Radioimmunoassay of IgG and IgM rheumatoid factors reacting with human IgG. J Immunol. 1977 Jul;119(1):295–300. [PubMed] [Google Scholar]
  5. Conn D. L., McDuffie F. C., Dyck P. J. Immunopathologic study of sural nerves in rheumatoid arthritis. Arthritis Rheum. 1972 Mar-Apr;15(2):135–143. doi: 10.1002/art.1780150202. [DOI] [PubMed] [Google Scholar]
  6. Erhardt C. C., Mumford P., Maini R. N. The association of cryoglobulinaemia with nodules, vasculitis and fibrosing alveolitis in rheumatoid arthritis and their relationship to serum C1q binding activity and rheumatoid factor. Clin Exp Immunol. 1979 Dec;38(3):405–413. [PMC free article] [PubMed] [Google Scholar]
  7. Franco A. E., Schur P. H. Hypocomplementemia in rheumatoid arthritis. Arthritis Rheum. 1971 Mar-Apr;14(2):231–238. doi: 10.1002/art.1780140206. [DOI] [PubMed] [Google Scholar]
  8. Fritzler M. J., Tan E. M. Antibodies to histones in drug-induced and idiopathic lupus erythematosus. J Clin Invest. 1978 Sep;62(3):560–567. doi: 10.1172/JCI109161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hay F. C., Nineham L. J., Roitt I. M. Routine assay for detection of IgG and IgM antiglobulins in seronegative and seropositive rheumatoid arthritis. Br Med J. 1975 Jul 26;3(5977):203–204. doi: 10.1136/bmj.3.5977.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Howell F. A., Chamberlain M. A., Perry R. A., Torrigiani G., Roitt I. M. IgG antiglobulin levels in patients with psoriatic arthropathy, ankylosing spondylitis, and gout. Ann Rheum Dis. 1972 Mar;31(2):129–131. doi: 10.1136/ard.31.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hunder G. G., McDuffie F. C. Hypocomplementemia in rheumatoid arthritis. Am J Med. 1973 Apr;54(4):461–472. doi: 10.1016/0002-9343(73)90042-9. [DOI] [PubMed] [Google Scholar]
  12. Kallerup H. E., Egeskjold E. M., Graudal H. IgG-, IgM- and IgA-rheumatoid factors in healthy adults and rheumatoid patients determined by an indirect immunofluorescence method. Scand J Rheumatol. 1979;8(1):1–9. [PubMed] [Google Scholar]
  13. Madsen L. H., Rodkey L. S. A method for preparing IgG F(ab')2 fragments using small amounts of serum. J Immunol Methods. 1976;9(3-4):355–361. doi: 10.1016/0022-1759(76)90210-6. [DOI] [PubMed] [Google Scholar]
  14. Pope R. M., McDuffy S. J. IgG rheumatoid factor. Relationship to seropositive rheumatoid arthritis and absence in seronegative disorders. Arthritis Rheum. 1979 Sep;22(9):988–998. doi: 10.1002/art.1780220907. [DOI] [PubMed] [Google Scholar]
  15. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  16. Rapoport R. J., Kozin F., Mackel S. E., Jordon R. E. Cutaneous vascular immunofluorescence in rheumatoid arthritis. Correlation with circulating immune complexes and vasculitis. Am J Med. 1980 Mar;68(3):325–331. doi: 10.1016/0002-9343(80)90100-x. [DOI] [PubMed] [Google Scholar]
  17. Scott D. G., Bacon P. A., Tribe C. R. Systemic rheumatoid vasculitis: a clinical and laboratory study of 50 cases. Medicine (Baltimore) 1981 Jul;60(4):288–297. [PubMed] [Google Scholar]
  18. Theofilopoulos A. N., Burtonboy G., LoSpalluto J. J., Ziff M. IgM rheumatoid factor and low molecular weight IgM. An association with vasculitis. Arthritis Rheum. 1974 May-Jun;17(3):272–284. doi: 10.1002/art.1780170312. [DOI] [PubMed] [Google Scholar]
  19. Venables P. J., Erhardt C. C., Maini R. N. Antibodies to extractable nuclear antigens in rheumatoid arthritis: relationship to vasculitis and circulating immune complexes. Clin Exp Immunol. 1980 Jan;39(1):146–153. [PMC free article] [PubMed] [Google Scholar]
  20. WARD D. J., JOHNSON G. D., HOLBOROW E. J. ANTINUCLEAR FACTOR IN RHEUMATOID ARTHRITIS, ITS INCIDENCE AND CLINICAL SIGNIFICANCE. Ann Rheum Dis. 1964 Jul;23:306–310. doi: 10.1136/ard.23.4.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Weisman M., Zvaifler N. Cryoimmunoglobulinemia in rheumatoid arthritis. Significance in serum of patients with rheumatoid vasculitis. J Clin Invest. 1975 Sep;56(3):725–739. doi: 10.1172/JCI108144. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES