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. 1983 May;52(2):393–398.

The late reaction following bronchial provocation with house dust mite allergen. Dependence on arachidonic acid metabolism.

A J Fairfax, J M Hanson, J Morley
PMCID: PMC1535850  PMID: 6861377

Abstract

The involvement of arachidonic acid metabolism in early and late bronchial reactions has been studied in four asthmatic subjects sensitive to Dermatophagoides pteronyssinus. Pre-treatment with either indomethacin (an inhibitor of the cyclo-oxygenase pathway) or benoxaprofen (an inhibitor of both cyclo-oxygenase and lipoxygenase pathways) failed to affect the amplitude, but did produce some foreshortening of the early response to allergen. If benoxaprofen is an effective inhibitor of SRS-A formation in vivo, then these observations question the role of SRS-A as a spasmogen in allergen-induced bronchospasm. Both drugs were effective inhibitors of the late reaction, implying involvement of cyclo-oxygenase products (endoperoxides, prostaglandins or thromboxanes) in the genesis of a late response to allergen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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