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. 1983 Nov;54(2):298–304.

Suppressor cell activity and phenotypes in the blood or tissues of patients with leprosy.

T H Rea
PMCID: PMC1535877  PMID: 6228349

Abstract

Suppressor cell activity has been demonstrated in the peripheral blood of patients with leprosy. Cells bearing the suppressor/cytotoxic phenotype have been enumerated in both peripheral blood and tissues, and microanatomical differences in tissue distribution have been observed. This first generation of studies has been characterized by considerable disagreement, a not unusual circumstance in the study of leprosy. In the case of blood suppressor cell activity, there appears to be no doubt as to its existence, but much uncertainty regarding its distribution. Concerning peripheral blood phenotypic suppressor cells, the observed differences in lepromatous and ENL patients may well reflect differences in methods used. Concerning phenotypic suppressor cells in tissue, there is no agreement as to their numbers or microanatomical distribution across the spectrum of leprosy or in its reaction states. Although these observational differences make firm conclusions impossible, this first generation of studies has provided new ways of considering old problems. For example, lepromin unresponsiveness might be a consequence of active cellular suppression. Differences in the numbers (or percentages) of the suppressor phenotype in blood or tissues of lepromatous patients with or without ENL reopens the door to the possibility of cell-mediated immune mechanisms in the pathogenesis of ENL. The identification of defective suppressor cells as important in the pathogenesis of hypergammaglobulinaemia is of interest in and of itself, but also gives rise to the possibility that other kinds of phenomena may be a consequence of defective or effete suppressor mechanisms. The observation of microanatomical differences in the distribution of the suppressor phenotype in tuberculoid and lepromatous leprosy indicates that effective or ineffective immunity might be a sequela of particular interactions between the suppressor/cytotoxic and helper/inducer phenotypes, and that these interactions merit further study. These new perspectives may be subject to experimental testing by the next generation of studies, which will surely include the techniques of clonal expansion and limiting dilution, as well as the study of interleukins 1 and 2.

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Selected References

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  1. Bach M. A., Chatenoud L., Wallach D., Phan Dinh Tuy F., Cottenot F. Studies on T cell subsets and functions in leprosy. Clin Exp Immunol. 1981 Jun;44(3):491–500. [PMC free article] [PubMed] [Google Scholar]
  2. Bach M. A., Wallach D., Flageul B., Cottenot F. In vitro proliferative response to M. leprae and PPD of isolated T cell subsets from leprosy patients. Clin Exp Immunol. 1983 Apr;52(1):107–114. [PMC free article] [PubMed] [Google Scholar]
  3. Bjune G. In vitro lymphocyte stimulation in leprosy; simultaneous stimulation with Mycobacterium leprae antigens and phytohaemagglutinin. Clin Exp Immunol. 1979 Jun;36(3):479–487. [PMC free article] [PubMed] [Google Scholar]
  4. Bullock W. E., Watson S., Nelson K. E., Schauf V., Makonkawkeyoon S., Jacobson R. R. Aberrant immunoregulatory control of B lymphocyte function in lepromatous leprosy. Clin Exp Immunol. 1982 Jul;49(1):105–114. [PMC free article] [PubMed] [Google Scholar]
  5. Mehra V., Convit J., Rubinstein A., Bloom B. R. Activated suppressor T cells in leprosy. J Immunol. 1982 Nov;129(5):1946–1951. [PubMed] [Google Scholar]
  6. Mehra V., Mason L. H., Fields J. P., Bloom B. R. Lepromin-induced suppressor cells in patients with leprosy. J Immunol. 1979 Oct;123(4):1813–1817. [PubMed] [Google Scholar]
  7. Mehra V., Mason L. H., Rothman W., Reinherz E., Schlossman S. F., Bloom B. R. Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients. J Immunol. 1980 Sep;125(3):1183–1188. [PubMed] [Google Scholar]
  8. Modlin R. L., Gebhard J. F., Taylor C. R., Rea T. H. In situ characterization of T lymphocyte subsets in the reactional states of leprosy. Clin Exp Immunol. 1983 Jul;53(1):17–24. [PMC free article] [PubMed] [Google Scholar]
  9. Modlin R. L., Hofman F. M., Meyer P. R., Sharma O. P., Taylor C. R., Rea T. H. In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis. Clin Exp Immunol. 1983 Mar;51(3):430–438. [PMC free article] [PubMed] [Google Scholar]
  10. Modlin R. L., Hofman F. M., Taylor C. R., Rea T. H. In situ characterization of T lymphocyte subsets in leprosy granulomas. Int J Lepr Other Mycobact Dis. 1982 Sep;50(3):361–362. [PubMed] [Google Scholar]
  11. Modlin R. L., Hofman F. M., Taylor C. R., Rea T. H. T lymphocyte subsets in the skin lesions of patients with leprosy. J Am Acad Dermatol. 1983 Feb;8(2):182–189. doi: 10.1016/s0190-9622(83)70021-6. [DOI] [PubMed] [Google Scholar]
  12. Mshana R. N., Haregewoin A., Harboe M., Belehu A. Thymus dependent lymphocytes in leprosy. I. T lymphocyte subpopulations defined by monoclonal antibodies. Int J Lepr Other Mycobact Dis. 1982 Sep;50(3):291–296. [PubMed] [Google Scholar]
  13. Myrvang B., Godal T., Ridley D. S., Fröland S. S., Song Y. K. Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. Clin Exp Immunol. 1973 Aug;14(4):541–553. [PMC free article] [PubMed] [Google Scholar]
  14. Narayanan R. B., Bhutani L. K., Sharma A. K., Nath I. T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies. Clin Exp Immunol. 1983 Mar;51(3):421–429. [PMC free article] [PubMed] [Google Scholar]
  15. Nath I., Narayanan R. B., Mehra N. K., Sharma A. K., Gupte M. D. Concanavalin A induced suppressor activity in human leprosy. J Clin Lab Immunol. 1979 Nov;2(4):319–324. [PubMed] [Google Scholar]
  16. Nath I., Singh R. The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy. Clin Exp Immunol. 1980 Sep;41(3):406–414. [PMC free article] [PubMed] [Google Scholar]
  17. Nath I., Van Rood J. J., Mehra N. K., Vaidya M. C. Natural suppressor cells in human leprosy: the role of HLA-D-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses. Clin Exp Immunol. 1980 Nov;42(2):203–210. [PMC free article] [PubMed] [Google Scholar]
  18. Reinherz E. L., Kung P. C., Goldstein G., Schlossman S. F. A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol. 1980 Mar;124(3):1301–1307. [PubMed] [Google Scholar]
  19. Ridley D. S., Waters M. F. Significance of variations within the lepromatous group. Lepr Rev. 1969 Jul;40(3):143–152. doi: 10.5935/0305-7518.19690026. [DOI] [PubMed] [Google Scholar]
  20. Stoner G. L., Atlaw T., Touw J., Belehu A. Antigen-specific suppressor cells in subclinical leprosy infection. Lancet. 1981 Dec 19;2(8260-61):1372–1377. doi: 10.1016/s0140-6736(81)92798-7. [DOI] [PubMed] [Google Scholar]
  21. Stoner G. L., Mshana R. N., Touw J., Belehu A. Studies on the defect in cell-mediated immunity in lepromatous leprosy using HLA-D-identical siblings. Absence of circulating suppressor cells and evidence that the defect is in the T-lymphocyte, rather than the monocyte, population. Scand J Immunol. 1982 Jan;15(1):33–48. doi: 10.1111/j.1365-3083.1982.tb00619.x. [DOI] [PubMed] [Google Scholar]
  22. Van Voorhis W. C., Kaplan G., Sarno E. N., Horwitz M. A., Steinman R. M., Levis W. R., Nogueira N., Hair L. S., Gattass C. R., Arrick B. A. The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes. N Engl J Med. 1982 Dec 23;307(26):1593–1597. doi: 10.1056/NEJM198212233072601. [DOI] [PubMed] [Google Scholar]
  23. Wallach D., Cottenot F., Bach M. A. Imbalances in T cell subpopulations in lepromatous leprosy. Int J Lepr Other Mycobact Dis. 1982 Sep;50(3):282–290. [PubMed] [Google Scholar]

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