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. 1983 Nov;54(2):327–336.

Monoclonal antibodies to human leucocyte antigens in polymyositis and muscular dystrophy.

D Rowe, D A Isenberg, P C Beverley
PMCID: PMC1535911  PMID: 6228350

Abstract

Biopsy specimens from patients with treated or untreated polymyositis and muscular dystrophy controls were examined by indirect immunoperoxidase staining with a panel of monoclonal antibodies to human leucocyte antigens. In untreated polymyositis, helper/inducer T cells were the predominant T cell subset. In treated cases few T cells were seen. Overall, few T cells were seen in dystrophic cases, most infiltrating cells being dendritic and lacking T cell antigens. Staining of sarcolemma with anti-HLA class 1 antibody is weak or negative except in areas adjacent to infiltrating leucocytes or where muscle fibre damage is apparent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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