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. 1984 Mar;55(3):473–480.

Reticuloendothelial Fc receptor function in SLE patients. I. Primary HLA linked defect or acquired dysfunction secondary to disease activity?

F J van der Woude, M van der Giessen, C G Kallenberg, W Ouwehand, H Beekhuis, J M Beelen, W J van Son, P J Hoedemaeker, G K van der Hem, T H The
PMCID: PMC1535936  PMID: 6584255

Abstract

Reticuloendothelial system (RES) Fc receptor-mediated immune clearance was measured in 18 patients with systemic lupus erythematosus (SLE). Only two patients, with major disease activity, had a prolonged T 1/2 of the blood disappearance curve of injected IgG coated red cells in comparison to 22 healthy controls. Circulating immune complexes (CIC) were studied with three methods: PEG precipitation, C1q-ELISA and the indirect granulocyte phagocytosis test (IGFT). The T 1/2 of the blood disappearance curve related significantly to the IGFT (r = 0.55, P less than 0.05) and not to the PEG and C1q-ELISA test. Although HLA-DR3 phenotype frequency was significantly increased in our SLE population (P less than 0.05), it was not related to Fc receptor function. Similarly, HLA-DR2 phenotype was not related to RES Fc receptor function. These data do not support the concept that a genetic HLA linked defect in reticuloendothelial Fc receptor function is a primary cause of SLE, predisposing the inflicted individual to immune complex deposition. However, Fc receptor-mediated immune clearance seems to be related to disease activity itself and to levels of CIC.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aarden L. A., de Groot E. R., Feltkamp T. E. Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann N Y Acad Sci. 1975 Jun 30;254:505–515. doi: 10.1111/j.1749-6632.1975.tb29197.x. [DOI] [PubMed] [Google Scholar]
  2. Elkon K. B., Ferjencik P. P., Walport M. J., Peters A. M., Lewis S. M., Hughes G. R. Evaluation of heat-damaged and IgG-coated red cells for testing reticuloendothelial function. J Immunol Methods. 1982 Dec 17;55(2):253–263. doi: 10.1016/0022-1759(82)90037-0. [DOI] [PubMed] [Google Scholar]
  3. Elkon K. B., Sewell J. R., Ryan P. F., Hughes G. R. Splenic function in non-renal systemic lupus erythematosus. Am J Med. 1980 Jul;69(1):80–82. doi: 10.1016/0002-9343(80)90503-3. [DOI] [PubMed] [Google Scholar]
  4. Frank M. M., Hamburger M. I., Lawley T. J., Kimberly R. P., Plotz P. H. Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med. 1979 Mar 8;300(10):518–523. doi: 10.1056/NEJM197903083001002. [DOI] [PubMed] [Google Scholar]
  5. Frank M. M., Lawley T. J., Hamburger M. I., Brown E. J. NIH Conference: Immunoglobulin G Fc receptor-mediated clearance in autoimmune diseases. Ann Intern Med. 1983 Feb;98(2):206–218. doi: 10.7326/0003-4819-98-2-218. [DOI] [PubMed] [Google Scholar]
  6. Kallenberg C. G., van der Meulen J., Pastoor G. W., Snijder J. A., Feltkamp T. E., The T. H. Human fibroblasts, a convenient nuclear substrate for detection of anti-nuclear antibodies including anti-centromere antibodies. Scand J Rheumatol. 1983;12(3):193–200. doi: 10.3109/03009748309098532. [DOI] [PubMed] [Google Scholar]
  7. Kimberly R. P., Gibofsky A., Salmon J. E., Fotino M. Impaired fc-mediated mononuclear phagocyte system clearance in HLA-DR2 and MT1-positive healthy young adults. J Exp Med. 1983 May 1;157(5):1698–1703. doi: 10.1084/jem.157.5.1698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lawley T. J., Hall R. P., Fauci A. S., Katz S. I., Hamburger M. I., Frank M. M. Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects. N Engl J Med. 1981 Jan 22;304(4):185–192. doi: 10.1056/NEJM198101223040401. [DOI] [PubMed] [Google Scholar]
  9. Lockwood C. M., Worlledge S., Nicholas A., Cotton C., Peters D. K. Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange. N Engl J Med. 1979 Mar 8;300(10):524–530. doi: 10.1056/NEJM197903083001003. [DOI] [PubMed] [Google Scholar]
  10. NIH conference. Pathophysiology of immune hemolytic anemia. Ann Intern Med. 1977 Aug;87(2):210–222. doi: 10.7326/0003-4819-87-2-210. [DOI] [PubMed] [Google Scholar]
  11. Parris T. M., Kimberly R. P., Inman R. D., McDougal J. S., Gibofsky A., Christian C. L. Defective Fc receptor-mediated function of the mononuclear phagocyte system in lupus nephritis. Ann Intern Med. 1982 Oct;97(4):526–532. doi: 10.7326/0003-4819-97-4-526. [DOI] [PubMed] [Google Scholar]
  12. van Rood J. J., van Leeuwen A., Ploem J. S. Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants. Nature. 1976 Aug 26;262(5571):795–797. doi: 10.1038/262795a0. [DOI] [PubMed] [Google Scholar]
  13. van der Woude F. J., Piers D. A., van der Giessen M., Hoedemaeker P. J., The T. H., van der Hem G. K. Abnormal reticuloendothelial function in patients with active vasculitis and idiopathic membranous glomerulopathy. A study with 99mTc-labeled heat-damaged autologous red blood cells. Eur J Nucl Med. 1983;8(2):60–64. doi: 10.1007/BF00252557. [DOI] [PubMed] [Google Scholar]

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