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. 1984 Apr;56(1):153–158.

Transplacental transmission of antibodies to tubular basement membrane in guinea-pigs with autoimmune tubulointerstitial nephritis.

B Albini, M Milgrom, B Noble, C Albini, E Ossi, G A Andres
PMCID: PMC1535950  PMID: 6370517

Abstract

The offspring of female guinea-pigs with tubulo-interstitial nephritis were studied for possible passive transfer of disease. Whereas no immune deposits were seen on or before day 30 of gestation, IgG was detected in the tubular basement membrane (TBM) of fetuses at and after day 44. Serum of offspring contained antibodies to TBM, albeit in much lower titres than found in circulation of the mother guinea-pigs. No histopathological changes were seen in fetal kidneys. Thus, autoantibodies induced by heteroimmunization of pregnant guinea-pigs may be transmitted to offspring in the last third of the gestation period and can bind to fetal TBM. However, this transfer of antibodies does not cause disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARNES J. M. Antitoxin transfer from mother to foetus in the guinea-pig. J Pathol Bacteriol. 1959 Apr;77(2):371–380. doi: 10.1002/path.1700770206. [DOI] [PubMed] [Google Scholar]
  2. BLIZZARD R. M., CHANDLER R. W., LANDING B. H., PETTIT M. D., WEST C. D. Maternal autoimmunization to thyroid as a probable cause of athyrotic cretinism. N Engl J Med. 1960 Aug 18;263:327–336. doi: 10.1056/NEJM196008182630702. [DOI] [PubMed] [Google Scholar]
  3. Beutner E. H., Sepulveda M. R., Barnett E. V. Quantitative studies of immunofluorescent staining. Relationships of characteristics of unabsorbed antihuman IgG conjugates to their specific and non-specific staining properties in an indirect test for antinuclear factors. Bull World Health Organ. 1968;39(4):587–606. [PMC free article] [PubMed] [Google Scholar]
  4. DANCIS J., SHAFRAN M. The origin of plasma proteins in the guinea pig fetus. J Clin Invest. 1958 Aug;37(8):1093–1099. doi: 10.1172/JCI103698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. EPSTEIN R. D., LOZNER E. L., COBBEY T. S., Jr, DAVIDSON C. S. Congenial thrombocytopenic purpura; purpura hemorrhagica in pregnancy and in the newborn. Am J Med. 1950 Jul;9(1):44–56. doi: 10.1016/0002-9343(50)90007-6. [DOI] [PubMed] [Google Scholar]
  6. Holubar K., Stingl G., Albini B. Praxis und Methodologie der definierten Immunfluoreszenztechnik. Eine kurzgefasste Arbeitsamleitung für das klinische Laboratorium bzw. für die ärztliche Praxis. Hautarzt. 1976 Feb;27(2):78–89. [PubMed] [Google Scholar]
  7. Namba T., Brown S. B., Grob D. Neonatal myasthenia gravis: report of two cases and review of the literature. Pediatrics. 1970 Mar;45(3):488–504. [PubMed] [Google Scholar]
  8. Steblay R. W., Rudofsky U. Renal tubular disease and autoantibodies against tubular basement membrane induced in guinea pigs. J Immunol. 1971 Aug;107(2):589–594. [PubMed] [Google Scholar]
  9. Steblay R. W., Rudofsky U. Transfer of experimental autoimmune renal cortical tubular and interstitial disease in guinea pigs by serum. Science. 1973 Jun 1;180(4089):966–968. doi: 10.1126/science.180.4089.966. [DOI] [PubMed] [Google Scholar]
  10. Van Zwieten M. J., Bhan A. K., McCluskey R. T., Collins A. B. Studies on the pathogenesis of experimental anti-tubular basement membrane nephritis in the guinea pig. Am J Pathol. 1976 Jun;83(3):531–546. [PMC free article] [PubMed] [Google Scholar]

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