Abstract
Fetal and maternal macrophage populations in human utero-placental tissues at different stages of gestation have been studied using immunohistological and histochemical techniques. A large population of macrophages has been identified within maternal decidualized endometrium in both term and first trimester tissues, although lymphoid cells also constitute a major component of the bone marrow derived cells in the decidua of early pregnancy. In contrast, fetal macrophages have been shown to contribute nearly all of the substantial bone marrow derived cell population within placental chorionic villous mesenchyme and within the mesenchyme of the term amniochorion. Apart from a small population of stellate intensely HLA-DR positive cells in term placental villous stroma, these extra-embryonic fetal macrophages could be shown consistently to express both the leu-M3 tissue macrophage antigen and lysosomal enzyme activities. It is suggested that the major HLA-DR positive cell population of fetal amniochorion comprises 'classical' macrophages rather than dendritic type cells. These various macrophage populations may perform vital phagocytic and degradative functions within utero-placental tissues and amniochorion.
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- Bulmer J. N., Billington W. D., Johnson P. M. Immunohistologic identification of trophoblast populations in early human pregnancy with the use of monoclonal antibodies. Am J Obstet Gynecol. 1984 Jan 1;148(1):19–26. doi: 10.1016/s0002-9378(84)80026-5. [DOI] [PubMed] [Google Scholar]
- Bulmer J. N., Sunderland C. A. Bone-marrow origin of endometrial granulocytes in the early human placental bed. J Reprod Immunol. 1983 Nov;5(6):383–387. doi: 10.1016/0165-0378(83)90247-4. [DOI] [PubMed] [Google Scholar]
- Dalchau R., Kirkley J., Fabre J. W. Monoclonal antibody to a human leukocyte-specific membrane glycoprotein probably homologous to the leukocyte-common (L-C) antigen of the rat. Eur J Immunol. 1980 Oct;10(10):737–744. doi: 10.1002/eji.1830101003. [DOI] [PubMed] [Google Scholar]
- Dimitriu-Bona A., Burmester G. R., Waters S. J., Winchester R. J. Human mononuclear phagocyte differentiation antigens. I. Patterns of antigenic expression on the surface of human monocytes and macrophages defined by monoclonal antibodies. J Immunol. 1983 Jan;130(1):145–152. [PubMed] [Google Scholar]
- Enders A. C., King B. F. The cytology of Hofbauer cells. Anat Rec. 1970 Jun;167(2):231–236. doi: 10.1002/ar.1091670211. [DOI] [PubMed] [Google Scholar]
- Faulk W. P., Jarret R., Keane M., Johnson P. M., Boackle R. J. Immunological studies of human placentae: complement components in immature and mature chorionic villi. Clin Exp Immunol. 1980 May;40(2):299–305. [PMC free article] [PubMed] [Google Scholar]
- Fox H., Kharkongor N. F. Enzyme histochemistry of the Hofbauer cells of the human placenta. J Obstet Gynaecol Br Commonw. 1969 Oct;76(10):918–921. doi: 10.1111/j.1471-0528.1969.tb15730.x. [DOI] [PubMed] [Google Scholar]
- Fox H. The incidence and significance of Hofbauer cells in the mature human placenta. J Pathol Bacteriol. 1967 Apr;93(2):710–717. doi: 10.1002/path.1700930239. [DOI] [PubMed] [Google Scholar]
- Fuggle S. V., Errasti P., Daar A. S., Fabre J. W., Ting A., Morris P. J. Localization of major histocompatibility complex (HLA-ABC and DR) antigens in 46 kidneys. Differences in HLA-DR staining of tubules among kidneys. Transplantation. 1983 Apr;35(4):385–390. doi: 10.1097/00007890-198304000-00024. [DOI] [PubMed] [Google Scholar]
- Gerdes J., Naiem M., Mason D. Y., Stein H. Human complement (C3b) receptors defined by a mouse monoclonal antibody. Immunology. 1982 Apr;45(4):645–653. [PMC free article] [PubMed] [Google Scholar]
- Hanjan S. N., Kearney J. F., Cooper M. D. A monoclonal antibody (MMA) that identifies a differentiation antigen on human myelomonocytic cells. Clin Immunol Immunopathol. 1982 May;23(2):172–188. doi: 10.1016/0090-1229(82)90106-4. [DOI] [PubMed] [Google Scholar]
- Hoyes A. D. Structure and function of the amnion. Obstet Gynecol Annu. 1975;4:1–38. [PubMed] [Google Scholar]
- Jenkins D. M., O'Neill M., Johnson P. M. HLA-DR-positive cells in the human amniochorion. Immunol Lett. 1983 Feb;6(2):65–67. doi: 10.1016/0165-2478(83)90082-2. [DOI] [PubMed] [Google Scholar]
- Johnson P. M., Brown P. J. Review article: Fc gamma receptors in the human placenta. Placenta. 1981 Oct-Dec;2(4):355–370. doi: 10.1016/s0143-4004(81)80031-8. [DOI] [PubMed] [Google Scholar]
- Johnson P. M., Bulmer J. N. Uterine gland epithelium in human pregnancy often lacks detectable maternal MHC antigens but does express fetal trophoblast antigens. J Immunol. 1984 Apr;132(4):1608–1610. [PubMed] [Google Scholar]
- Johnson P. M., Faulk W. P. Immunological studies of human placentae: identification and distribution of proteins in immature chorionic villi. Immunology. 1978 Jun;34(6):1027–1035. [PMC free article] [PubMed] [Google Scholar]
- Johnson P. M., Faulk W. P. Immunological studies of human placentae: identification and distribution of proteins in immature chorionic villi. Immunology. 1978 Jun;34(6):1027–1035. [PMC free article] [PubMed] [Google Scholar]
- Johnson P. M., Molloy C. M. Localization in human term placental bed and amniochorion of cells bearing trophoblast antigens identified by monoclonal antibodies. Am J Reprod Immunol. 1983 Jul-Aug;4(1):33–37. doi: 10.1111/j.1600-0897.1983.tb00250.x. [DOI] [PubMed] [Google Scholar]
- Loke Y. W., Eremin O., Ashby J., Day S. Characterization of the phagocytic cells isolated from the human placenta. J Reticuloendothel Soc. 1982 Apr;31(4):317–324. [PubMed] [Google Scholar]
- McMichael A. J., Pilch J. R., Galfré G., Mason D. Y., Fabre J. W., Milstein C. A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur J Immunol. 1979 Mar;9(3):205–210. doi: 10.1002/eji.1830090307. [DOI] [PubMed] [Google Scholar]
- Mishra B. B., Poulter L. W., Janossy G., James D. G. The distribution of lymphoid and macrophage like cell subsets of sarcoid and Kveim granulomata: possible mechanism of negative PPD reaction in sarcoidosis. Clin Exp Immunol. 1983 Dec;54(3):705–715. [PMC free article] [PubMed] [Google Scholar]
- Poulter L. W. Antigen presenting cells in situ: their identification and involvement in immunopathology. Clin Exp Immunol. 1983 Sep;53(3):513–520. [PMC free article] [PubMed] [Google Scholar]
- Sunderland C. A., Redman C. W., Stirrat G. M. Monoclonal antibodies to human syncytiotrophoblast. Immunology. 1981 Jul;43(3):541–546. [PMC free article] [PubMed] [Google Scholar]
- Sutton L., Mason D. Y., Redman C. W. HLA-DR positive cells in the human placenta. Immunology. 1983 May;49(1):103–112. [PMC free article] [PubMed] [Google Scholar]
- Terhorst C., van Agthoven A., LeClair K., Snow P., Reinherz E., Schlossman S. Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10. Cell. 1981 Mar;23(3):771–780. doi: 10.1016/0092-8674(81)90441-4. [DOI] [PubMed] [Google Scholar]
- Wood G. W. Mononuclear phagocytes in the human placenta. Placenta. 1980 Apr-Jun;1(2):113–123. doi: 10.1016/s0143-4004(80)80019-1. [DOI] [PubMed] [Google Scholar]