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. 1983 Oct;54(1):1–13.

The interferons.

J L Toy
PMCID: PMC1536188  PMID: 6193915

Abstract

An overview of the interferons is presented. A description of something of what is known about them is given, including: their genes; their protein structures and characteristics; their mechanisms of actions; and their varied biological effects emphasising particularly their immunomodulatory actions. Finally, a brief summary is made of the current status of human clinical studies that have been conducted with interferons in the oncological and viral fields, mentioning also recent findings in patients who have the acquired immunodeficiency syndrome (AIDS).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen G., Fantes K. H. A family of structural genes for human lymphoblastoid (leukocyte-type) interferon. Nature. 1980 Oct 2;287(5781):408–411. doi: 10.1038/287408a0. [DOI] [PubMed] [Google Scholar]
  2. Arvin A. M., Kushner J. H., Feldman S., Baehner R. L., Hammond D., Merigan T. C. Human leukocyte interferon for the treatment of varicella in children with cancer. N Engl J Med. 1982 Apr 1;306(13):761–765. doi: 10.1056/NEJM198204013061301. [DOI] [PubMed] [Google Scholar]
  3. Ausiello C., Hokland P., Heron I. Interferon-induced augmentation of cytotoxic killer cell generation in mixed lymphocyte cultures: analysis of the effector cell product. Scand J Immunol. 1981;13(3):263–270. doi: 10.1111/j.1365-3083.1981.tb00134.x. [DOI] [PubMed] [Google Scholar]
  4. Balkwill F., Taylor-Papadimitriou J. Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth. Nature. 1978 Aug 24;274(5673):798–800. doi: 10.1038/274798a0. [DOI] [PubMed] [Google Scholar]
  5. Beck G., Poindron P., Illinger D., Beck J. P., Ebel J. P., Falcoff R. Inhibition of steroid inducible tyrosine aminotransferase by mouse and rat interferon in hepatoma tissue culture cells. FEBS Lett. 1974 Nov 15;48(2):297–300. doi: 10.1016/0014-5793(74)80490-4. [DOI] [PubMed] [Google Scholar]
  6. Besancon F., Ankel H. Binding of interferon to gangliosides. Nature. 1974 Dec 6;252(5483):478–480. doi: 10.1038/252478a0. [DOI] [PubMed] [Google Scholar]
  7. Billiau A. The clinical value of interferons as antitumor agents. Eur J Cancer Clin Oncol. 1981 Sep;17(9):949–967. doi: 10.1016/s0277-5379(81)80001-6. [DOI] [PubMed] [Google Scholar]
  8. Borden E. C., Holland J. F., Dao T. L., Gutterman J. U., Wiener L., Chang Y. C., Patel J. Leukocyte-derived interferon (alpha) in human breast carcinoma. The American Cancer Society phase II trial. Ann Intern Med. 1982 Jul;97(1):1–6. doi: 10.7326/0003-4819-97-1-1. [DOI] [PubMed] [Google Scholar]
  9. Borgström S., von Eyben F. E., Flodgren P., Axelsson B., Sjögren H. O. Human leukocyte interferon and cimetidine for metastatic melanoma. N Engl J Med. 1982 Oct 21;307(17):1080–1081. doi: 10.1056/nejm198210213071716. [DOI] [PubMed] [Google Scholar]
  10. Braun W., Levy H. B. Interferon preparations as modifiers of immune responses. Proc Soc Exp Biol Med. 1972 Dec;141(3):769–773. doi: 10.3181/00379727-141-36868. [DOI] [PubMed] [Google Scholar]
  11. Broder S., Muul L., Waldmann T. A. Suppressor cells in neoplastic disease. J Natl Cancer Inst. 1978 Jul;61(1):5–11. doi: 10.1093/jnci/61.1.5. [DOI] [PubMed] [Google Scholar]
  12. Brouty-Boyé D., Gresser I. Reversibility of the transformed and neoplastic phenotype. I. Progressive reversion of the phenotype of X-ray-transformed C3H/10T1/2 cells under prolonged treatment with interferon. Int J Cancer. 1981 Aug 15;28(2):165–173. doi: 10.1002/ijc.2910280209. [DOI] [PubMed] [Google Scholar]
  13. Brunda M. J., Herberman R. B., Holden H. T. Inhibition of murine natural killer cell activity by prostaglandins. J Immunol. 1980 Jun;124(6):2682–2687. [PubMed] [Google Scholar]
  14. Chandrabose K., Cuatrecasas P., Pottathil R. Changes in fatty acyl chains of phospholipids induced by interferon in mouse sarcoma S-180 cells. Biochem Biophys Res Commun. 1981 Feb 12;98(3):661–668. doi: 10.1016/0006-291x(81)91165-7. [DOI] [PubMed] [Google Scholar]
  15. Chany C. Membrane-bound interferon specific cell receptor system: role in the establishment and amplification of the antiviral state. Biomedicine. 1976 Jun;24(3):148–157. [PubMed] [Google Scholar]
  16. Chirigos M. A., Schultz R. M., Stylos W. A. Interaction of interferon, macrophage, and lymphocyte tumoricidal activity with prostaglandin effect. Ann N Y Acad Sci. 1980;350:91–101. doi: 10.1111/j.1749-6632.1980.tb20610.x. [DOI] [PubMed] [Google Scholar]
  17. Cochran A. J., Nestor M. S., Groopman J. E., Ahmed A. R. Tumor infiltrates in acquired immunodeficiency syndrome patients with Kaposi's sarcoma. Lancet. 1983 Feb 19;1(8321):416–416. doi: 10.1016/s0140-6736(83)91528-3. [DOI] [PubMed] [Google Scholar]
  18. Collett R. A. Arylsulphatase activity in liver and gastrointestinal tract of sheep [proceedings]. Biochem Soc Trans. 1980 Jun;8(3):343–344. doi: 10.1042/bst0080343. [DOI] [PubMed] [Google Scholar]
  19. Creasey A. A., Bartholomew J. C., Merigan T. C. Role of G0-G1 arrest in the inhibition of tumor cell growth by interferon. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1471–1475. doi: 10.1073/pnas.77.3.1471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Cupples C. G., Tan Y. H. Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome. Nature. 1977 May 12;267(5607):165–167. doi: 10.1038/267165a0. [DOI] [PubMed] [Google Scholar]
  21. De Maeyer-Guignard J., Cachard A., De Maeyer E. Delayed-type hypersensitivity to sheep red blood cells: inhibition of sensitization by interferon. Science. 1975 Nov 7;190(4214):574–576. doi: 10.1126/science.1188355. [DOI] [PubMed] [Google Scholar]
  22. De Maeyer E., De Maeyer-Guignard J. Host genotype influences immunomodulation by interferon. Nature. 1980 Mar 13;284(5752):173–175. doi: 10.1038/284173a0. [DOI] [PubMed] [Google Scholar]
  23. De Maeyer E., De Maeyer-Guignard J., Vandeputte M. Inhibition by interferon of delayed-type hypersensitivity in the mouse. Proc Natl Acad Sci U S A. 1975 May;72(5):1753–1757. doi: 10.1073/pnas.72.5.1753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. DeStefano E., Friedman R. M., Friedman-Kien A. E., Goedert J. J., Henriksen D., Preble O. T., Sonnabend J. A., Vilcek J. Acid-labile human leukocyte interferon in homosexual men with Kaposi's sarcoma and lymphadenopathy. J Infect Dis. 1982 Oct;146(4):451–459. doi: 10.1093/infdis/146.4.451. [DOI] [PubMed] [Google Scholar]
  25. Derynck R., Content J., DeClercq E., Volckaert G., Tavernier J., Devos R., Fiers W. Isolation and structure of a human fibroblast interferon gene. Nature. 1980 Jun 19;285(5766):542–547. doi: 10.1038/285542a0. [DOI] [PubMed] [Google Scholar]
  26. Djeu J. Y., Huang K. Y., Herberman R. B. Augmentation of mouse natural killer activity and induction of interferon by tumor cells in vivo. J Exp Med. 1980 Apr 1;151(4):781–789. doi: 10.1084/jem.151.4.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Durack D. T. Opportunistic infections and Kaposi's sarcoma in homosexual men. N Engl J Med. 1981 Dec 10;305(24):1465–1467. doi: 10.1056/NEJM198112103052408. [DOI] [PubMed] [Google Scholar]
  28. Einhorn S., Blomgren H., Strander H. Interferon and spontaneous cytotoxicity in man. II. Studies in patients receiving exogenous leukocyte interferon. Acta Med Scand. 1978;204(6):477–483. [PubMed] [Google Scholar]
  29. Epstein D. A., Torrence P. F., Friedman R. M. Double-stranded RNA inhibits a phosphoprotein phosphatase present in interferon-treated cells. Proc Natl Acad Sci U S A. 1980 Jan;77(1):107–111. doi: 10.1073/pnas.77.1.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Epstein L. B., Epstein C. J. Localization fo the gene AVG for the antiviral expression of immune and classical interferon to the distal portion of the long arm of chromosome 21. J Infect Dis. 1976 Jun;133 (Suppl):A56–A62. doi: 10.1093/infdis/133.supplement_2.a56. [DOI] [PubMed] [Google Scholar]
  31. Epstein L. B., Kreth H. W., Herzenberg L. A. Fluorescence-activated cell sorting of human T and B lymphocytes. II. Identification of the cell type responsible for interferon production and cell proliferation in response to mitogens. Cell Immunol. 1974 Jun;12(3):407–421. doi: 10.1016/0008-8749(74)90097-5. [DOI] [PubMed] [Google Scholar]
  32. Falcoff R. Some properties of virus and immune-induced human lymphocyte interferons. J Gen Virol. 1972 Aug;16(2):251–253. doi: 10.1099/0022-1317-16-2-251. [DOI] [PubMed] [Google Scholar]
  33. Fellous M., Kamoun M., Gresser I., Bono R. Enhanced expression of HLA antigens and beta 2-microglobulin on interferon-treated human lymphoid cells. Eur J Immunol. 1979 Jun;9(6):446–449. doi: 10.1002/eji.1830090606. [DOI] [PubMed] [Google Scholar]
  34. Fitzpatrick F. A., Stringfellow D. A. Virus and interferon effects on cellular prostaglandin biosynthesis. J Immunol. 1980 Jul;125(1):431–437. [PubMed] [Google Scholar]
  35. Fradelizi D., Gresser I. Interferon inhibits the generation of allospecific suppressor T lymphocytes. J Exp Med. 1982 Jun 1;155(6):1610–1622. doi: 10.1084/jem.155.6.1610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Friedman R. M., Cooper H. L. Stimulation of interferon production in human lymphocytes by mitogens. Proc Soc Exp Biol Med. 1967 Jul;125(3):901–905. doi: 10.3181/00379727-125-32235. [DOI] [PubMed] [Google Scholar]
  37. Fuse A., Mahmud I., Kuwata T. Mechanism of stimulation by human interferon of prostaglandin synthesis in human cell lines. Cancer Res. 1982 Aug;42(8):3209–3214. [PubMed] [Google Scholar]
  38. Gisler R. H., Lindahl P., Gresser I. Effects of interferon on antibody synthesis in vitro. J Immunol. 1974 Aug;113(2):438–444. [PubMed] [Google Scholar]
  39. Goeddel D. V., Leung D. W., Dull T. J., Gross M., Lawn R. M., McCandliss R., Seeburg P. H., Ullrich A., Yelverton E., Gray P. W. The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature. 1981 Mar 5;290(5801):20–26. doi: 10.1038/290020a0. [DOI] [PubMed] [Google Scholar]
  40. Goeddel D. V., Yelverton E., Ullrich A., Heyneker H. L., Miozzari G., Holmes W., Seeburg P. H., Dull T., May L., Stebbing N. Human leukocyte interferon produced by E. coli is biologically active. Nature. 1980 Oct 2;287(5781):411–416. doi: 10.1038/287411a0. [DOI] [PubMed] [Google Scholar]
  41. Gray P. W., Goeddel D. V. Structure of the human immune interferon gene. Nature. 1982 Aug 26;298(5877):859–863. doi: 10.1038/298859a0. [DOI] [PubMed] [Google Scholar]
  42. Gresser I., Bandu M. T., Brouty-Boyé D. Interferon and cell division. IX. Interferon-resistant L1210 cells: characteristics and origin. J Natl Cancer Inst. 1974 Feb;52(2):553–559. doi: 10.1093/jnci/52.2.553. [DOI] [PubMed] [Google Scholar]
  43. Gresser I., Coppey J., Falcoff E., Fontaine D. Interferon and murine leukemia. I. Inhibitory effect of interferon preparations on development of friend leukemia in mice. Proc Soc Exp Biol Med. 1967 Jan;124(1):84–91. doi: 10.3181/00379727-124-31672. [DOI] [PubMed] [Google Scholar]
  44. Gresser I., Tovey M. G. Antitumor effects of interferon. Biochim Biophys Acta. 1978 Oct 27;516(2):231–247. doi: 10.1016/0304-419x(78)90009-4. [DOI] [PubMed] [Google Scholar]
  45. Grollman E. F., Lee G., Ramos S., Lazo P. S., Kaback H. R., Friedman R. M., Kohn L. D. Relationships of the structure and function of the interferon receptor to hormone receptors and establishment of the antiviral state. Cancer Res. 1978 Nov;38(11 Pt 2):4172–4185. [PubMed] [Google Scholar]
  46. Gutterman J. U., Blumenschein G. R., Alexanian R., Yap H. Y., Buzdar A. U., Cabanillas F., Hortobagyi G. N., Hersh E. M., Rasmussen S. L., Harmon M. Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma. Ann Intern Med. 1980 Sep;93(3):399–406. doi: 10.7326/0003-4819-93-3-399. [DOI] [PubMed] [Google Scholar]
  47. Haglund S., Lundquist P. G., Cantell K., Strander H. Interferon therapy in juvenile laryngeal papillomatosis. Arch Otolaryngol. 1981 Jun;107(6):327–332. doi: 10.1001/archotol.1981.00790420001001. [DOI] [PubMed] [Google Scholar]
  48. Hamburg S. I., Cassell G. H., Rabinovitch M. Relationship between enhanced macrophage phagocytic activity and the induction of interferon by Newcastle disease virus in mice. J Immunol. 1980 Mar;124(3):1360–1364. [PubMed] [Google Scholar]
  49. Hansson M., Kiessling R., Andersson B., Welsh R. M. Effect of interferon and interferon inducers on the NK sensitivity of normal mouse thymocytes. J Immunol. 1980 Nov;125(5):2225–2231. [PubMed] [Google Scholar]
  50. Herberman R. B., Djeu J., Kay H. D., Ortaldo J. R., Riccardi C., Bonnard G. D., Holden H. T., Fagnani R., Santoni A., Puccetti P. Natural killer cells: characteristics and regulation of activity. Immunol Rev. 1979;44:43–70. doi: 10.1111/j.1600-065x.1979.tb00267.x. [DOI] [PubMed] [Google Scholar]
  51. Heron I., Berg K., Cantell K. Regulatory effect of interferon on T cells in vitro. J Immunol. 1976 Oct;117(4):1370–1373. [PubMed] [Google Scholar]
  52. Heron I., Berg K. Human leucocyte interferon: analysis of effect on MLC and effector cell generation. Scand J Immunol. 1979;9(6):517–526. doi: 10.1111/j.1365-3083.1979.tb03280.x. [DOI] [PubMed] [Google Scholar]
  53. Hibbs J. B., Jr, Taintor R. R., Chapman H. A., Jr, Weinberg J. B. Macrophage tumor killing: influence of the local environment. Science. 1977 Jul 15;197(4300):279–282. doi: 10.1126/science.327547. [DOI] [PubMed] [Google Scholar]
  54. Hochkeppel H. K., de Ley M. Monoclonal antibody against human IFN-gamma. Nature. 1982 Mar 18;296(5854):258–259. doi: 10.1038/296258a0. [DOI] [PubMed] [Google Scholar]
  55. Huang K. Y., Donahoe R. M., Gordon F. B., Dressler H. R. Enhancement of phagocytosis by interferon-containing preparations. Infect Immun. 1971 Nov;4(5):581–588. doi: 10.1128/iai.4.5.581-588.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Härfast B., Huddlestone J. R., Casali P., Merigan T. C., Oldstone M. B. Interferon acts directly on human B lymphocytes to modulate immunoglobulin synthesis. J Immunol. 1981 Nov;127(5):2146–2150. [PubMed] [Google Scholar]
  57. ISAACS A., LINDENMANN J. Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci. 1957 Sep 12;147(927):258–267. doi: 10.1098/rspb.1957.0048. [DOI] [PubMed] [Google Scholar]
  58. Imai K., Ng A. K., Glassy M. C., Ferrone S. Differential effect of interferon on the expression of tumor-associated antigens and histocompatibility antigens on human melanoma cells: relationship to susceptibility to immune lysis mediated by monoclonal antibodies. J Immunol. 1981 Aug;127(2):505–509. [PubMed] [Google Scholar]
  59. Imanishi J., Oishi K., Kishida T., Negoro Y., Iizuka M. Effects of interferon preparations on rabbit corneal xenograft. Arch Virol. 1977;53(1-2):157–161. doi: 10.1007/BF01314856. [DOI] [PubMed] [Google Scholar]
  60. Imanishi J., Yokota Y., Kishida T., Mukainaka T., Matsuo A. Phagocytosis-enhancing effect of human leukocyte interferon preparation of human peripheral monocytes in vitro. Acta Virol. 1975 Jan;19(1):52–58. [PubMed] [Google Scholar]
  61. Itoh K., Inoue M., Kataoka S., Kumagai K. Differential effect of interferon expression of IgG- and IgM-Fc receptors on human lymphocytes. J Immunol. 1980 Jun;124(6):2589–2595. [PubMed] [Google Scholar]
  62. Jett J. R., Mantovani A., Herberman R. B. Augmentation of human monocyte-mediated cytolysis by interferon. Cell Immunol. 1980 Sep 1;54(2):425–434. doi: 10.1016/0008-8749(80)90222-1. [DOI] [PubMed] [Google Scholar]
  63. Johnson H. M., Baron S. The nature of the suppressive effect of interferon and interferon inducers on the in vitro immune response. Cell Immunol. 1976 Jul;25(1):106–115. doi: 10.1016/0008-8749(76)90100-3. [DOI] [PubMed] [Google Scholar]
  64. Jordan G. W., Fried R. P., Merigan T. C. Administration of human leukocyte interferon in herpes zoster. I. Safety, circulating, antiviral activity, and host responses to infection. J Infect Dis. 1974 Jul;130(1):56–62. doi: 10.1093/infdis/130.1.56. [DOI] [PubMed] [Google Scholar]
  65. Kadish A. S., Tansey F. A., Yu G. S., Doyle A. T., Bloom B. R. Interferon as a mediator of human lymphocyte suppression. J Exp Med. 1980 Mar 1;151(3):637–650. doi: 10.1084/jem.151.3.637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Knight E., Jr, Korant B. D. A cell surface alteration in mouse L cells induced by interferon. Biochem Biophys Res Commun. 1977 Jan 24;74(2):707–713. doi: 10.1016/0006-291x(77)90360-6. [DOI] [PubMed] [Google Scholar]
  67. Kohn L. D., Friedman R. M., Holmes J. M., Lee G. Use of thyrotropin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3695–3699. doi: 10.1073/pnas.73.10.3695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Lawn R. M., Adelman J., Dull T. J., Gross M., Goeddel D., Ullrich A. DNA sequence of two closely linked human leukocyte interferon genes. Science. 1981 Jun 5;212(4499):1159–1162. doi: 10.1126/science.6165082. [DOI] [PubMed] [Google Scholar]
  69. Lengyel P. Biochemistry of interferons and their actions. Annu Rev Biochem. 1982;51:251–282. doi: 10.1146/annurev.bi.51.070182.001343. [DOI] [PubMed] [Google Scholar]
  70. Lindahl-Magnusson P., Leary P., Gresser I. Interferon and cell division. VI. Inhibitory effect of interferon on the multiplication of mouse embryo and mouse kidney cells in primary cultures. Proc Soc Exp Biol Med. 1971 Dec;138(3):1044–1050. doi: 10.3181/00379727-138-36047. [DOI] [PubMed] [Google Scholar]
  71. Lindahl-Magnusson P., Leary P., Gresser I. Interferon inhibits DNA synthesis induced in mouse lymphocyte suspensions by phytohaemagglutinin or by allogeneic cells. Nat New Biol. 1972 May 24;237(73):120–121. doi: 10.1038/newbio237120a0. [DOI] [PubMed] [Google Scholar]
  72. McCabe B. F., Clark K. F. Interferon and laryngeal papillomatosis. The Iowa experience. Ann Otol Rhinol Laryngol. 1983 Jan-Feb;92(1 Pt 1):2–7. doi: 10.1177/000348948309200102. [DOI] [PubMed] [Google Scholar]
  73. Merigan T. C. Interferon-the first quarter century. JAMA. 1982 Nov 19;248(19):2513–2516. [PubMed] [Google Scholar]
  74. Merigan T. C., Rand K. H., Pollard R. B., Abdallah P. S., Jordan G. W., Fried R. P. Human leukocyte interferon for the treatment of herpes zoster in patients with cancer. N Engl J Med. 1978 May 4;298(18):981–987. doi: 10.1056/NEJM197805042981801. [DOI] [PubMed] [Google Scholar]
  75. Merigan T. C., Reed S. E., Hall T. S., Tyrrell D. A. Inhibition of respiratory virus infection by locally applied interferon. Lancet. 1973 Mar 17;1(7803):563–567. doi: 10.1016/s0140-6736(73)90714-9. [DOI] [PubMed] [Google Scholar]
  76. Moore M., White W. J., Potter M. R. Modulation of target cell susceptibility to human natural killer cells by interferon. Int J Cancer. 1980 May 15;25(5):565–572. doi: 10.1002/ijc.2910250504. [DOI] [PubMed] [Google Scholar]
  77. Männel D., De Maeyer E., Kemler R., Cachard A., De Maeyer-Guignard J. A rat monoclonal antibody against mouse alpha and beta interferon of all molecular weight species. Nature. 1982 Apr 15;296(5858):664–665. doi: 10.1038/296664a0. [DOI] [PubMed] [Google Scholar]
  78. Nagata S., Mantei N., Weissmann C. The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature. 1980 Oct 2;287(5781):401–408. doi: 10.1038/287401a0. [DOI] [PubMed] [Google Scholar]
  79. Ortaldo J. R., Pestka S., Slease R. B., Rubinstein M., Herberman R. B. Augmentation of human K-cell activity with interferon. Scand J Immunol. 1980;12(5):365–369. doi: 10.1111/j.1365-3083.1980.tb00079.x. [DOI] [PubMed] [Google Scholar]
  80. Owerbach D., Rutter W. J., Shows T. B., Gray P., Goeddel D. V., Lawn R. M. Leukocyte and fibroblast interferon genes are located on human chromosome 9. Proc Natl Acad Sci U S A. 1981 May;78(5):3123–3127. doi: 10.1073/pnas.78.5.3123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Parrillo J. E., Fauci A. S. Comparison of the effector cells in human spontaneous cellular cytotoxicity and antibody-dependent cellular cytotoxicity: differential sensitivity of effector cells to in vivo and in vitro corticosteroids. Scand J Immunol. 1978;8(2):99–107. doi: 10.1111/j.1365-3083.1978.tb00501.x. [DOI] [PubMed] [Google Scholar]
  82. Pazin G. J., Ho M., Haverkos H. W., Armstrong J. A., Breinig M. C., Wechsler H. L., Arvin A., Merigan T. C., Cantell K. Effects of interferon-alpha on human warts. J Interferon Res. 1982;2(2):235–243. doi: 10.1089/jir.1982.2.235. [DOI] [PubMed] [Google Scholar]
  83. Pfeffer L. M., Wang E., Tamm I. Interferon effects on microfilament organization, cellular fibronectin distribution, and cell motility in human fibroblasts. J Cell Biol. 1980 Apr;85(1):9–17. doi: 10.1083/jcb.85.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Pfeffer L. M., Wang E., Tamm I. Interferon inhibits the redistribution of cell surface components. J Exp Med. 1980 Aug 1;152(2):469–474. doi: 10.1084/jem.152.2.469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Pottathil R., Chandrabose K. A., Cuatrecasas P., Lang D. J. Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5437–5440. doi: 10.1073/pnas.77.9.5437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  86. Preble O. T., Black R. J., Friedman R. M., Klippel J. H., Vilcek J. Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon. Science. 1982 Apr 23;216(4544):429–431. doi: 10.1126/science.6176024. [DOI] [PubMed] [Google Scholar]
  87. Quesada J. R., Swanson D. A., Trindade A., Gutterman J. U. Renal cell carcinoma: antitumor effects of leukocyte interferon. Cancer Res. 1983 Feb;43(2):940–947. [PubMed] [Google Scholar]
  88. Rasmussen L., Merigan T. C. Effect of interferon therapy on circulating lymphocytes in humans. J Interferon Res. 1980 Fall;1(1):101–110. doi: 10.1089/jir.1980.1.101. [DOI] [PubMed] [Google Scholar]
  89. Rossi G. B., Dolei A., Cioé L., Benedetto A., Matarese G. P., Belardelli F. Inhibition of transcription and translation of globin messenger RNA in dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated with interferon. Proc Natl Acad Sci U S A. 1977 May;74(5):2036–2040. doi: 10.1073/pnas.74.5.2036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Rousseau G. G., Quivy J. I., Kirchhoff J., Bui X. H., Devis R. Nonsteroidal compounds which bind epididymal androgen-binding protein but not the androgen receptor. Nature. 1980 Apr 3;284(5755):458–459. doi: 10.1038/284458a0. [DOI] [PubMed] [Google Scholar]
  91. Sagar A. D., Sehgal P. B., Slate D. L., Ruddle F. H. Multiple human beta interferon genes. J Exp Med. 1982 Sep 1;156(3):744–755. doi: 10.1084/jem.156.3.744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  92. Schultz R. M., Chirigos M. A., Heine U. I. Functional and morphologic characteristics of interferon-treated macrophages. Cell Immunol. 1978 Jan;35(1):84–91. doi: 10.1016/0008-8749(78)90128-4. [DOI] [PubMed] [Google Scholar]
  93. Schultz R. M., Papamatheakis J. D., Chirigos M. A. Interferon: an inducer of macrophage activation by polyanions. Science. 1977 Aug 12;197(4304):674–676. doi: 10.1126/science.877584. [DOI] [PubMed] [Google Scholar]
  94. Scott G. M., Phillpotts R. J., Wallace J., Secher D. S., Cantell K., Tyrrell D. A. Purified interferon as protection against rhinovirus infection. Br Med J (Clin Res Ed) 1982 Jun 19;284(6332):1822–1825. doi: 10.1136/bmj.284.6332.1822. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Scullard G. H., Andres L. L., Greenberg H. B., Smith J. L., Sawhney V. K., Neal E. A., Mahal A. S., Popper H., Merigan T. C., Robinson W. S. Antiviral treatment of chronic hepatitis B virus infection: improvement in liver disease with interferon and adenine arabinoside. Hepatology. 1981 May-Jun;1(3):228–232. doi: 10.1002/hep.1840010306. [DOI] [PubMed] [Google Scholar]
  96. Secher D. S., Burke D. C. A monoclonal antibody for large-scale purification of human leukocyte interferon. Nature. 1980 Jun 12;285(5765):446–450. doi: 10.1038/285446a0. [DOI] [PubMed] [Google Scholar]
  97. Sikora K., Smedley H. Interferon and cancer. Br Med J (Clin Res Ed) 1983 Mar 5;286(6367):739–740. doi: 10.1136/bmj.286.6367.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
  98. Silva A., Bonavida B., Targan S. Mode of action of interferon-mediated modulation of natural killer cytotoxic activity: recruitment of pre-NK cells and enhanced kinetics of lysis. J Immunol. 1980 Aug;125(2):479–484. [PubMed] [Google Scholar]
  99. Sonnenfeld G., Meruelo D., McDevitt H. O., Merigan T. C. Effect of type I and type II interferons on murine thymocyte surface antigen expression: induction or selection? Cell Immunol. 1981 Jan 15;57(2):427–439. doi: 10.1016/0008-8749(81)90101-5. [DOI] [PubMed] [Google Scholar]
  100. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  101. Sreevalsan T., Taylor-Papadimitriou J., Rozengurt E. Selective inhibition by interferon of serum-stimulated biochemical events in 3T3 cells. Biochem Biophys Res Commun. 1979 Apr 13;87(3):679–685. doi: 10.1016/0006-291x(79)92012-6. [DOI] [PubMed] [Google Scholar]
  102. Strander H., Cantell K., Carlström G., Jakobsson P. A. Clinical and laboratory investigations on man: systemic administration of potent interferon to man. J Natl Cancer Inst. 1973 Sep;51(3):733–742. doi: 10.1093/jnci/51.3.733. [DOI] [PubMed] [Google Scholar]
  103. Streuli M., Nagata S., Weissmann C. At least three human type alpha interferons: structure of alpha 2. Science. 1980 Sep 19;209(4463):1343–1347. doi: 10.1126/science.6158094. [DOI] [PubMed] [Google Scholar]
  104. Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., Weissmann C. Human leukocyte and fibroblast interferons are structurally related. Nature. 1980 Jun 19;285(5766):547–549. doi: 10.1038/285547a0. [DOI] [PubMed] [Google Scholar]
  105. Tovey M. G., Brouty-Boyé D. The use of the chemostat to study the relationship between cell growth rate, viability, and the effect of interferon on L 1210 cells. Exp Cell Res. 1979 Feb;118(2):383–388. doi: 10.1016/0014-4827(79)90162-9. [DOI] [PubMed] [Google Scholar]
  106. Trinchieri G., Granato D., Perussia B. Interferon-induced resistance of fibroblasts to cytolysis mediated by natural killer cells: specificity and mechanism. J Immunol. 1981 Jan;126(1):335–340. [PubMed] [Google Scholar]
  107. Trinchieri G., Santoli D., Koprowski H. Spontaneous cell-mediated cytotoxicity in humans: role of interferon and immunoglobulins. J Immunol. 1978 Jun;120(6):1849–1855. [PubMed] [Google Scholar]
  108. Vignaux F., Gresser I. Differential effects of interferon on the expression of H-2K, H-2D, and Ia antigens on mouse lymphocytes. J Immunol. 1977 Feb;118(2):721–723. [PubMed] [Google Scholar]
  109. Vignaux F., Gresser I., Fridman W. H. Effect of virus-induced interferon on the antibody response of suckling and adult mice. Eur J Immunol. 1980 Oct;10(10):767–772. doi: 10.1002/eji.1830101008. [DOI] [PubMed] [Google Scholar]
  110. Vánky F. T., Argov S. A., Einhorn S. A., Klein E. Role of alloantigens in natural killing. Allogeneic but not autologous tumor biopsy cells are sensitive for interferon-induced cytotoxicity of human blood lymphcoytes. J Exp Med. 1980 May 1;151(5):1151–1165. doi: 10.1084/jem.151.5.1151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  111. Vánky F., Argov S. Human tumor-lymphocyte interaction in vitro. VII. Blastogenesis and generation of cytotoxicity against autologous tumor biopsy cells are inhibited by interferon. Int J Cancer. 1980 Oct 15;26(4):405–411. doi: 10.1002/ijc.2910260404. [DOI] [PubMed] [Google Scholar]
  112. Wallach D., Fellous M., Revel M. Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs in human cells. Nature. 1982 Oct 28;299(5886):833–836. doi: 10.1038/299833a0. [DOI] [PubMed] [Google Scholar]
  113. Weil J., Epstein C. J., Epstein L. B., Sedmak J. J., Sabran J. L., Grossberg S. E. A unique set of polypeptides is induced by gamma interferon in addition to those induced in common with alpha and beta interferons. Nature. 1983 Feb 3;301(5899):437–439. doi: 10.1038/301437a0. [DOI] [PubMed] [Google Scholar]
  114. Weimar W., Heijtink R. A., ten Kate F. J., Schalm S. W., Masurel N., Schellekens H., Cantell K. Double-blind study of leucocyte interferon administration in chronic HBsAg-positive hepatitis. Lancet. 1980 Feb 16;1(8164):336–338. doi: 10.1016/s0140-6736(80)90885-5. [DOI] [PubMed] [Google Scholar]
  115. Wiranowska-Stewart M. Heterogeneity of human gamma interferon preparations: evidence for presence of alpha interferon. J Interferon Res. 1981 Feb;1(2):315–321. doi: 10.1089/jir.1981.1.315. [DOI] [PubMed] [Google Scholar]
  116. Yaron M., Yaron I., Gurari-Rotman D., Revel M., Lindner H. R., Zor U. Stimulation of prostaglandin E production in cultured human fibroblasts by poly(I)-poly(C) and human interferon. Nature. 1977 Jun 2;267(5610):457–459. doi: 10.1038/267457a0. [DOI] [PubMed] [Google Scholar]
  117. Yip Y. K., Barrowclough B. S., Urban C., Vilcek J. Purification of two subspecies of human gamma (immune) interferon. Proc Natl Acad Sci U S A. 1982 Mar;79(6):1820–1824. doi: 10.1073/pnas.79.6.1820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  118. Zoon K. C. Purification and characterization of human interferon from lymphoblastoid (Namalva) cultures. Methods Enzymol. 1981;78(Pt A):457–464. doi: 10.1016/0076-6879(81)78156-4. [DOI] [PubMed] [Google Scholar]
  119. de Ley M., van Damme J., Claeys H., Weening H., Heine J. W., Billiau A., Vermylen C., de Somer P. Interferon induced in human leukocytes by mitogens: production, partial purification and characterization. Eur J Immunol. 1980 Nov;10(11):877–883. doi: 10.1002/eji.1830101113. [DOI] [PubMed] [Google Scholar]
  120. de Maeyer E., Mobraaten L., de Maeyer-Guignard J. Prolongation par l'interféron de la survie des greffes de peau chez la souris. C R Acad Sci Hebd Seances Acad Sci D. 1973 Nov 12;277(19):2101–2103. [PubMed] [Google Scholar]
  121. von Wussow P., Platsoucas C. D., Wiranowska-Stewart M., Stewart W. E., 2nd Human gamma interferon production by leukocytes induced with monoclonal antibodies recognizing T cells. J Immunol. 1981 Sep;127(3):1197–1200. [PubMed] [Google Scholar]

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