Abstract
Antibodies to the lipopolysaccharide (LPS) and protein antigens of S. typhi in secretions of small intestine obtained from 12 typhoid patients, four typhoid carriers and 16 non-typhoid control subjects were measured by a solid-phase radioimmunoassay technique. Intestinal secretions obtained from typhoid patients as a group had significantly higher anti-LPS and anti-protein antibodies than those from the control group. These antibodies were both IgM and IgA classes. There was no correlation between the IgM or IgA antibody levels in serum and those in the intestinal secretions. In the intestinal secretions obtained from typhoid carriers, on the other hand, only IgA-class antibodies to the LPS and protein antigens of S. typhi were present at high levels.
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Selected References
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- Brandtzaeg P., Fjellanger I., Gjeruldsen S. T. Immunoglobulin M: local synthesis and selective secretion in patients with immunoglobulin A deficiency. Science. 1968 May 17;160(3829):789–791. doi: 10.1126/science.160.3829.789. [DOI] [PubMed] [Google Scholar]
- Goldberg L. S., Barnett E. V., Fudenberg H. H. Selective absence of IgA: a family study. J Lab Clin Med. 1968 Aug;72(2):204–212. [PubMed] [Google Scholar]
- La Brooy J. T., Davidson G. P., Sherman D. J., Rowley D. The antibody response to bacterial gastroenteritis in serum and secretions. Clin Exp Immunol. 1980 Aug;41(2):290–296. [PMC free article] [PubMed] [Google Scholar]
- ROCKEY J. H., HANSON L. A., HEREMANS J. F., KUNKEL H. G. BETA-2A AGLOBULINEMIA IN TWO HEALTHY MEN. J Lab Clin Med. 1964 Feb;63:205–212. [PubMed] [Google Scholar]
- Thompson R. A. Secretory piece linked to IgM in individuals deficient in IgA. Nature. 1970 Jun 6;226(5249):946–948. doi: 10.1038/226946a0. [DOI] [PubMed] [Google Scholar]
- Tsang R. S., Chau P. Y., Lam S. K., La Brooy J. T., Rowley D. Antibody response to the lipopolysaccharide and protein antigens of Salmonella typhi during typhoid infection. I. Measurement of serum antibodies by radioimmunoassay. Clin Exp Immunol. 1981 Dec;46(3):508–514. [PMC free article] [PubMed] [Google Scholar]
- Walker W. A. Host defense mechanisms in the gastrointestinal tract. Pediatrics. 1976 Jun;57(6):901–916. [PubMed] [Google Scholar]