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. 1982 Jan;47(1):19–26.

Selective immunosuppressive effects of measles virus infection.

B K Pelton, W Hylton, A M Denman
PMCID: PMC1536360  PMID: 6284422

Abstract

The antibody response to diphtheria toxoid by cultured tonsil cells was suppressed by measles virus, which productively infected a small percentage of both T and B lymphocytes. However, infection of cultures spontaneously secreting antibody and immunoglobulin (with Herpes simplex virus) or measles virus did not result in immunosuppression. Immunosuppression by measles virus may thus be attributed to a selective effect on the inductive phase of the response and suggest that infection of immunoglobulin-producing B lymphocytes does not alter the ability of these cells to secrete antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. GRESSER I., CHANY C. Isolation of measles virus from the washed leucocytic fraction of blood. Proc Soc Exp Biol Med. 1963 Jul;113:695–698. doi: 10.3181/00379727-113-28465. [DOI] [PubMed] [Google Scholar]
  2. Joseph B. S., Lampert P. W., Oldstone M. B. Replication and persistence of measles virus in defined subpopulations of human leukocytes. J Virol. 1975 Dec;16(6):1638–1649. doi: 10.1128/jvi.16.6.1638-1649.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Lucas C. J., Ubels-Postma J. C., Rezee A., Galama J. M. Activation of measles virus from silently infected human lymphocytes. J Exp Med. 1978 Oct 1;148(4):940–952. doi: 10.1084/jem.148.4.940. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. McFarland H. F. The effect of measles virus infection on T and B lymphocytes in the mouse. I. Suppression of helper cell activity. J Immunol. 1974 Dec;113(6):1978–1983. [PubMed] [Google Scholar]
  5. Neighbour P. A., Bloom B. R. Absence of virus-induced lymphocyte suppression and interferon production in multiple sclerosis. Proc Natl Acad Sci U S A. 1979 Jan;76(1):476–480. doi: 10.1073/pnas.76.1.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Osunkoya B. O., Adeleye G. I., Adejumo T. A., Salimonu L. S. Studies on leukocyte cultures in measles. II. Detection of measles virus antigen in human leucocytes by immunofluorescence. Arch Gesamte Virusforsch. 1974;44(4):323–329. doi: 10.1007/BF01251013. [DOI] [PubMed] [Google Scholar]
  7. Pelton B. K., Duncan I. B., Denman A. M. Herpes simplex virus depresses antibody production by affecting T-cell function. Nature. 1980 Mar 13;284(5752):176–177. doi: 10.1038/284176a0. [DOI] [PubMed] [Google Scholar]
  8. Pelton B. K., Imrie R. C., Denman A. M. Susceptibility of human lymphocyte populations to infection by herpes simplex virus. Immunology. 1977 May;32(5):803–810. [PMC free article] [PubMed] [Google Scholar]
  9. Rager-Zisman B., Merigan T. C. A useful quantitative semimicromethod for viral plaque assay. Proc Soc Exp Biol Med. 1973 Apr;142(4):1174–1179. doi: 10.3181/00379727-142-37202. [DOI] [PubMed] [Google Scholar]
  10. Sullivan J. L., Barry D. W., Albrecht P., Lucas S. J. Inhibition of lymphocyte stimulation by measles virus. J Immunol. 1975 May;114(5):1458–1461. [PubMed] [Google Scholar]
  11. Sullivan J. L., Barry D. W., Lucas S. J., Albrecht P. Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes. J Exp Med. 1975 Sep 1;142(3):773–784. doi: 10.1084/jem.142.3.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Valdirmarsson H., Agnarsdottir G., Lachmann P. J. Measles virus receptor on human T lymphocytes. Nature. 1975 Jun 12;255(5509):554–556. doi: 10.1038/255554a0. [DOI] [PubMed] [Google Scholar]
  13. White R. G., Boyd J. F. The effect of measles on the thymus and other lymphoid tissues. Clin Exp Immunol. 1973 Mar;13(3):343–357. [PMC free article] [PubMed] [Google Scholar]
  14. Whittle H. C., Dossetor J., Oduloju A., Bryceson A. D., Greenwood B. M. Cell-mediated immunity during natural measles infection. J Clin Invest. 1978 Sep;62(3):678–684. doi: 10.1172/JCI109175. [DOI] [PMC free article] [PubMed] [Google Scholar]

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