Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1981 Nov;46(2):259–267.

Detection of immune complexes and their relationship to rheumatoid factor in a variety of autoimmune disorders.

R M Pope, S Yoshinoya, S J McDuffy
PMCID: PMC1536383  PMID: 7337971

Abstract

The sera of patient with adult rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) were employed together with sensitive radioimmunoassays to examine the relationship between immune complexes detected by three methods and the IgM, IgA and IgG classes of rheumatoid factors (RF). Compared to the controls, significantly increased concentrations of RF and immune complexes were detected for every patient group except JRA. Increased concentrations of IgA RF, IgG RF and immune complexes detected by the C1qBA and the C1qSP were strongly associated with the presence of IgM RF. Significant correlations were noted between RF (especially IgG and IgM) and immune complexes (detected by both the C1qBA and the C1qSP) for patients with RA, SLE and MCTD. These studies suggest that RF may be partially involved in the formation of the immune complexes detected by C1q-binding assays and demonstrate the need for further clarification of the constituents of the immune complexes detected in each disease.

Full text

PDF
259

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abrass C. K., Nies K. M., Louie J. S., Border W. A., Glassock R. J. Correlation and predictive accuracy of circulating immune complexes with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 1980 Mar;23(3):273–282. doi: 10.1002/art.1780230302. [DOI] [PubMed] [Google Scholar]
  2. Cochrane C. G., Koffler D. Immune complex disease in experimental animals and man. Adv Immunol. 1973;16(0):185–264. doi: 10.1016/s0065-2776(08)60298-9. [DOI] [PubMed] [Google Scholar]
  3. Gupta R. C., McDuffie F. C., Huston K. A., Tappeiner G., Meurer M., Jordon R. E., Luthra H. S., Hunder G. G., Ilstrup D. Comparison of three immunoassays for immune complexes in rheumatoid arthritis. Arthritis Rheum. 1979 May;22(5):433–439. doi: 10.1002/art.1780220501. [DOI] [PubMed] [Google Scholar]
  4. Halla J. T., Volanakis J. E., Schrohenloher R. E. Circulating immune complexes in mixed connective tissue disease. Arthritis Rheum. 1979 May;22(5):484–489. doi: 10.1002/art.1780220507. [DOI] [PubMed] [Google Scholar]
  5. Hay F. C., Nineham L. J., Perumal R., Roitt I. M. Intra-articular and circulating immune complexes and antiglobulins (IgG and IgM) in rheumatoid arthritis; correlation with clinical features. Ann Rheum Dis. 1979 Feb;38(1):1–7. doi: 10.1136/ard.38.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Howell F. A., Chamberlain M. A., Perry R. A., Torrigiani G., Roitt I. M. IgG antiglobulin levels in patients with psoriatic arthropathy, ankylosing spondylitis, and gout. Ann Rheum Dis. 1972 Mar;31(2):129–131. doi: 10.1136/ard.31.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lawley T. J., Moutsopoulos H. M., Katz S. I., Theofilopoulos A. N., Chused T. M., Frank M. M. Demonstration of circulating immune complexes in Sjögren's syndrome. J Immunol. 1979 Sep;123(3):1382–1387. [PubMed] [Google Scholar]
  8. Luthra H. S., McDuffie F. C., Hunder G. G., Samayoa E. A. Immune complexes in sera and synovial fluids of patients with rheumatoid arthritis. Radioimmunoassay with monocylonal rheumatoid factor. J Clin Invest. 1975 Aug;56(2):458–466. doi: 10.1172/JCI108112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McDuffie F. C., Hunder G. G., Clark R. J. Complement-fixing material in ther sera of patients with rheumatoid arthritis. Clin Exp Immunol. 1978 May;32(2):218–225. [PMC free article] [PubMed] [Google Scholar]
  10. Miller J. J., 3rd, Osborne C. L., Hsu Y. P. Clq binding in serum in juvenile rheumatoid arthritis. J Rheumatol. 1980 Sep-Oct;7(5):665–670. [PubMed] [Google Scholar]
  11. PLOTZ C. M., SINGER J. M. The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med. 1956 Dec;21(6):888–892. [PubMed] [Google Scholar]
  12. Pope R. M., McDuffy S. J. IgG rheumatoid factor. Relationship to seropositive rheumatoid arthritis and absence in seronegative disorders. Arthritis Rheum. 1979 Sep;22(9):988–998. doi: 10.1002/art.1780220907. [DOI] [PubMed] [Google Scholar]
  13. Pope R. M., McDuffy S. J. IgG rheumatoid factor: analysis of various species of IgG for detection by radioimmunoassay. J Lab Clin Med. 1981 Jun;97(6):842–853. [PubMed] [Google Scholar]
  14. Roberts-Thomson P. J., Neoh S. H., Bradley J., Milazzo S. C. Circulating and intra-articular immune complexes in rheumatoid arthritis: a comparative study of the C1q binding and monoclonal rheumatoid factor assays. Ann Rheum Dis. 1980 Oct;39(5):438–444. doi: 10.1136/ard.39.5.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sølling J., Sølling K., Lassen L. An evaluation of two methods for detection of circulating immune complexes in patients with rheumatoid arthritis. Scand J Rheumatol. 1980;9(2):118–122. doi: 10.3109/03009748009098140. [DOI] [PubMed] [Google Scholar]
  16. Torrigiani G., Ansell B. M., Chown E. E., Roitt I. M. Raised IgG antiglobulin factors in Still's disease. Ann Rheum Dis. 1969 Jul;28(4):424–427. doi: 10.1136/ard.28.4.424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Yoshinoya S., Cox R. A., Pope R. M. Circulating immune complexes in coccidioidomycosis. Detection and characterization. J Clin Invest. 1980 Oct;66(4):655–663. doi: 10.1172/JCI109901. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yoshinoya S., Pope R. M. Detection of immune complexes in acute rheumatic fever and their relationship to HLA-B5. J Clin Invest. 1980 Jan;65(1):136–145. doi: 10.1172/JCI109643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Zubler R. H., Lambert P. H. Detection of immune complexes in human diseases. Prog Allergy. 1978;24:1–48. [PubMed] [Google Scholar]
  20. Zubler R. H., Nydegger U., Perrin L. H., Fehr K., McCormick J., Lambert P. H., Miescher P. A. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976 May;57(5):1308–1319. doi: 10.1172/JCI108399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Zvaifler N. J. The immunopathology of joint inflammation in rheumatoid arthritis. Adv Immunol. 1973;16(0):265–336. doi: 10.1016/s0065-2776(08)60299-0. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES