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. 1982 Aug;49(2):371–376.

Effects of muramyl dipeptide on superoxide anion release and on anti-microbial activity of human macrophages.

C B Wilson, J Bohnsack, W M Weaver
PMCID: PMC1536489  PMID: 6290115

Abstract

Exposure of human monocyte derived macrophages to muramyl dipeptide in vitro increased phorbol myristate acetate-stimulated O2- release by these cells; the activity of such macrophages against Toxoplasma gondii or against Staphylococcus aureus was not increased. The failure of muramyl dipeptide to enhance human macrophage anti-microbial activity correlated with the failure of muramyl dipeptide to enhance O2- release in response to phagocytic stimuli. These results and those previously published by others indicate that muramyl dipeptide may enhance release of certain inflammatory mediators (O2- and endogenous pyrogen) without enhancing the anti-microbial activity of human macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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