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. 1982 Feb;47(2):253–259.

Role of antibody in the protection of mice from arthritis induced by Mycoplasma pulmonis.

E C Keystone, A J Cunningham, A Metcalfe, M Kennedy, P A Quinn
PMCID: PMC1536526  PMID: 7075023

Abstract

C3H and C57Bl10 mice exhibit a differential susceptibility to arthritis induced by Mycoplasma pulmonis. Resistant C57Bl10 mice consistently demonstrated higher complement-fixing antibody titres than susceptible C3H mice throughout the development of the acute arthritis. A strong correlation was demonstrated between the levels of anti-mycoplasma antibody and resistance to acute arthritis in six strains of mice. To test the hypothesis that the difference of arthritis resistance of C3H and C57Bl10 mice was caused by a different susceptibility of their lymphocytes to mitogenic stimulation by M. pulmonis, we investigated the generation of non-specific immunoglobulin in vivo and in vitro. M. pulmonis acted as a polyclonal mitogen, but stimulated approximately equal responses in lymphocytes of both strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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