Abstract
T Lymphocyte subpopulations were characterized by means of monoclonal antibodies in 44 pregnant women at different stages of gestation, and in 45 healthy controls. In the pregnant subjects, there is a small but significant reduction of the whole circulating T Lymphocytes and of their T helper subset identified respectively by OKT3 and OKT4 monoclonal antibodies. There is no influence of pregnancy on the proportions of T cytotoxic-suppressor cells (OKT8 positive) nor of lymphocytes bearing Ia antigen. Low counts of circulating cells with a thymocyte phenotype (OKT6 positive) are found in the two groups of subjects. It is concluded that pregnancy has a marginal effect on maternal immunocompetence.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Birkeland S. A., Kristoffersen K. Lymphocyte transformation with mitogens and antigens during normal human pregnancy: a longitudinal study. Scand J Immunol. 1980;11(3):321–325. doi: 10.1111/j.1365-3083.1980.tb00240.x. [DOI] [PubMed] [Google Scholar]
- Birkeland S. A., Kristoffersen K. T and B lymphocytes during normal human pregnancy: a longitudinal study. Scand J Immunol. 1979;10(5):415–419. doi: 10.1111/j.1365-3083.1979.tb01370.x. [DOI] [PubMed] [Google Scholar]
- Hirahara F., Gorai I., Tanaka K., Matsuzaki Y., Sumiyoshi Y., Shiojima Y. Cellular immunity in pregnancy: subpopulations of T lymphocytes bearing Fc receptors for IgG and IgM in pregnant women. Clin Exp Immunol. 1980 Aug;41(2):353–357. [PMC free article] [PubMed] [Google Scholar]
- Kung P. C., Talle M. A., DeMaria M. E., Butler M. S., Lifter J., Goldstein G. Strategies for generating monoclonal antibodies defining human t-lymphocyte differentiation antigens. Transplant Proc. 1980 Sep;12(3 Suppl 1):141–146. [PubMed] [Google Scholar]
- Rocklin R. E., Kitzmiller J. L., Kaye M. D. Immunobiology of the maternal-fetal relationship. Annu Rev Med. 1979;30:375–404. doi: 10.1146/annurev.me.30.020179.002111. [DOI] [PubMed] [Google Scholar]
- Strelkauskas A. J., Davies I. J., Dray S. Longitudinal studies showing alterations in the levels and functional response of T and B lymphocytes in human pregnancy. Clin Exp Immunol. 1978 Jun;32(3):531–539. [PMC free article] [PubMed] [Google Scholar]