Abstract
The presence of circulating antigen-antibody complexes in the sera of patients with onchocerciasis was investigated using the Clq and conglutinin solid-phase binding assays. Only 50% of patients' sera had demonstrable complexes, levels of complexes were unrelated to microfilarial load and specific anti-onchocercal antibody titres and results with the two tests for complexes were not correlated. Both IgM- and IgG-containing complexes were commonly involved but there was no correlation between the levels of complexes containing these isotypes. Evidence for the presence of IgE in complexes of sera from a minority of individuals was also obtained.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Devey M. E., Taylor J., Steward M. W. Measurement of antigen-antibody complexes in mouse sera by conglutinin, C1q and rheumatoid factor solid phase binding assays. J Immunol Methods. 1980;34(3):191–203. doi: 10.1016/0022-1759(80)90046-0. [DOI] [PubMed] [Google Scholar]
- Jones B. R., Anderson J., Fuglsang H. Effects of various concentrations of diethylcarbamazine citrate applied as eye drops in ocular onchocerciasis, and the possibilities of improved therapy from continuous non-pulsed delivery. Br J Ophthalmol. 1978 Jul;62(7):428–439. doi: 10.1136/bjo.62.7.428. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Martin M. F., Scott D. G., Gilbert C., Dieppe P. A., Easty D. L. Retinal vasculitis in rheumatoid arthritis. Br Med J (Clin Res Ed) 1981 May 30;282(6278):1745–1746. doi: 10.1136/bmj.282.6278.1745. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCarthy D., Goddard D. H., Pell B. K., Holborow E. J. Intrinsically stable IgG aggregates. J Immunol Methods. 1981;41(1):63–74. doi: 10.1016/0022-1759(81)90274-x. [DOI] [PubMed] [Google Scholar]
- Paganelli R., Ngu J. L., Levinsky R. J. Circulating immune complexes in onchocerciasis. Clin Exp Immunol. 1980 Mar;39(3):570–575. [PMC free article] [PubMed] [Google Scholar]
- Ripert C., Riedel D., Yang R., Fouda Onana A., Zimflou I. A. Etude épidémiologique de l'onchocercose dans cinq villages de la vallée de la Sanaga (Cameroun). Bull Soc Pathol Exot Filiales. 1977 Mar-Apr;70(2):178–186. [PubMed] [Google Scholar]
- Sanders M. D. Retinal vasculitis: a review. J R Soc Med. 1979 Dec;72(12):908–915. doi: 10.1177/014107687907201209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Voller A., Bidwell D. E., Bartlett A. Enzyme immunoassays in diagnostic medicine. Theory and practice. Bull World Health Organ. 1976;53(1):55–65. [PMC free article] [PubMed] [Google Scholar]
- Wong V. G., Anderson R., O'Brien P. J. Sympathetic ophthalmia and lymphocyte transformation. Am J Ophthalmol. 1971 Nov;72(5):960–966. doi: 10.1016/0002-9394(71)91697-7. [DOI] [PubMed] [Google Scholar]