Skip to main content
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1982 Jun;48(3):754–757.

75Se-methionine labelled Trypanosoma cruzi blood trypomastigotes: opsonization by chronic infection serum facilitates killing in spleen and liver.

M T Scott, L Moyes
PMCID: PMC1536600  PMID: 6811174

Abstract

Blood trypomastigote forms of Trypanosoma cruzi have been labelled with 75Se-methionine. Opsonization by sera from mice chronically infected with T. cruzi promoted their uptake by both liver and spleen. Opsonized parasites within spleens and livers were less infectious when transferred to normal recipients demonstrating in situ parasite killing by these organs.

Full text

PDF
754

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alcantara A., Brener Z. The in vitro interaction of Trypanosoma cruzi bloodstream forms and mouse peritoneal macrophages. Acta Trop. 1978 Sep;35(3):209–219. [PubMed] [Google Scholar]
  2. Holmes P. H., MacAskill J. A., Whitelaw D. D., Jennings F. W., Urquhart G. M. Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. I. Aspects of the radiolabelling technique. Immunology. 1979 Mar;36(3):415–420. [PMC free article] [PubMed] [Google Scholar]
  3. Kipnis T. L., James S. L., Sher A., David J. R. Cell-mediated cytotoxicity to Trypanosoma cruzi. II. Antibody-dependent killing of bloodstream forms by mouse eosinophils and neutrophils. Am J Trop Med Hyg. 1981 Jan;30(1):47–53. [PubMed] [Google Scholar]
  4. Krettli A. U., Brener Z. Protective effects of specific antibodies in Trypanosoma cruzi infections. J Immunol. 1976 Mar;116(3):755–760. [PubMed] [Google Scholar]
  5. McHardy N. Passive protection of mice against infection with Trypanosoma cruzi with plasma: the use of blood- and vector bug-derived trypomastigote challenge. Parasitology. 1980 Jun;80(3):471–478. doi: 10.1017/s0031182000000937. [DOI] [PubMed] [Google Scholar]
  6. Nogueira N., Chaplan S., Cohn Z. Trypanosoma cruzi. Factors modifying ingestion and fate of blood form trypomastigotes. J Exp Med. 1980 Aug 1;152(2):447–451. doi: 10.1084/jem.152.2.447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Okabe K., Kipnis T. L., Calich V. L., Dias da Silva W. Cell-mediated cytotoxicity to Trypanosoma cruzi. I. Antibody-dependent cell mediated cytotoxicity to trypomastigote bloodstream forms. Clin Immunol Immunopathol. 1980 Jul;16(3):344–353. doi: 10.1016/0090-1229(80)90140-3. [DOI] [PubMed] [Google Scholar]
  8. Scott M. T. Biological effects of the adjuvant Corynebacterium parvum. I. Inhibition of PHA, mixed lymphocyte and GVH reactivity. Cell Immunol. 1972 Nov;5(3):459–468. doi: 10.1016/0008-8749(72)90072-x. [DOI] [PubMed] [Google Scholar]
  9. Scott M. T. The nature of immunity against Trypanosoma cruzi in mice recovered from acute infection. Parasite Immunol. 1981 Autumn;3(3):209–218. doi: 10.1111/j.1365-3024.1981.tb00400.x. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES