Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1982 Jun;48(3):700–704.

Immune complex type disease induced by HgCl2 in Brown-Norway rats: genetic control of susceptibility.

C Sapin, C Mandet, E Druet, E Gunther, P Druet
PMCID: PMC1536601  PMID: 6214344

Abstract

Mercuric chloride induces a biphasic autoimmune glomerulonephritis in Brown-Norway (BN) rats but not in Lewis (LEW) rats. The genetic control of susceptibility to both phases was investigated by testing the response of segregants between BN and LEW rats and of congenic LEW.1N rats. It was confirmed that susceptibility to the first phase, characterized by the appearance of anti-glomerular basement membrane antibodies, depends on several genes one of which is RT1 linked. Susceptibility to the second phase, which is an immune complex type glomerulonephritis, was found to depend on one major RT1 linked gene or cluster of genes with a role for other(s) non-RT1 linked gene(s) controlling the magnitude of the response. However, congenic LEW.1N rats were found to be resistant. This suggests that the disease gene has been lost during the strain derivation. The question of whether both phases are two different diseases or expression of the same process cannot be definitely answered; data however indicate a dissociation of both disease processes.

Full text

PDF
700

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernaudin J. F., Druet E., Belair M. F., Pinchon M. C., Sapin C., Druet P. Extrarenal immune complex type deposits induced by mercuric chloride in the Brown Norway rat. Clin Exp Immunol. 1979 Nov;38(2):265–273. [PMC free article] [PubMed] [Google Scholar]
  2. Dixon F. J. The pathogenesis of glomerulonephritis. Am J Med. 1968 Apr;44(4):493–498. doi: 10.1016/0002-9343(68)90050-8. [DOI] [PubMed] [Google Scholar]
  3. Druet E., Fournie G., Mandet C., Sapin C., Günther E., Druet P. Genetic control of susceptibility to immune complex type nephritis induced by HgCl2 in rats. Transplant Proc. 1979 Sep;11(3):1600–1603. [PubMed] [Google Scholar]
  4. Druet E., Sapin C., Günther E., Feingold N., Druet P. Mercuric chloride-induced anti-glomerular basement membrane antibodies in the rat: genetic control. Eur J Immunol. 1977 Jun;7(6):348–351. doi: 10.1002/eji.1830070605. [DOI] [PubMed] [Google Scholar]
  5. Druet P., Druet E., Potdevin F., Sapin C. Immune type glomerulonephritis induced by HgCl2 in the Brown Norway rat. Ann Immunol (Paris) 1978 Oct-Dec;129 100(6):777–792. [PubMed] [Google Scholar]
  6. Gasser D. L., Newlin C. M., Palm J., Gonatas N. K. Genetic control of susceptibility to experimental allergic encephalomyelitis in rats. Science. 1973 Aug 31;181(4102):872–873. doi: 10.1126/science.181.4102.872. [DOI] [PubMed] [Google Scholar]
  7. Gasser D. L., Palm J., Gonatas N. K. Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats. J Immunol. 1975 Aug;115(2):431–433. [PubMed] [Google Scholar]
  8. Gill T. J., 3rd, Kunz H. W. Genetic and cellular factors in the immune response. II. Evidence for the polygenic control of the antibody response from further breeding studies and from pedigree analyses. J Immunol. 1971 Apr;106(4):980–992. [PubMed] [Google Scholar]
  9. Gritzka T. L., Trump B. F. Renal tubular lesions caused by mercuric chloride. Electron microscopic observations: degeneration of the pars recta. Am J Pathol. 1968 Jun;52(6):1225–1277. [PMC free article] [PubMed] [Google Scholar]
  10. Günther E. Close association between particular I region-determined cell surface antigens and Ir gene-controlled immune responsiveness to synthetic polypeptides in wild rats. Eur J Immunol. 1979 May;9(5):391–401. doi: 10.1002/eji.1830090510. [DOI] [PubMed] [Google Scholar]
  11. Günther E., Rüde E. Genetic complementation of histocompatibility-linked Ir genes in the rat. J Immunol. 1975 Nov;115(5):1387–1393. [PubMed] [Google Scholar]
  12. Luderer A. A., Maurer P. H., Woodland R. T. Genetic control of the immune response in rats to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n. I. Antibody responses. J Immunol. 1976 Oct;117(4):1079–1084. [PubMed] [Google Scholar]
  13. Lynch D. H., Dewitt C. W. Genetic identification of a locus linked to the rat MHC that codes for a membrane antigen detectable with cytotoxic lymphocytes. J Immunol. 1978 Dec;121(6):2367–2375. [PubMed] [Google Scholar]
  14. Sapin C., Druet E., Druet P. Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride. Clin Exp Immunol. 1977 Apr;28(1):173–179. [PMC free article] [PubMed] [Google Scholar]
  15. Sapin C., Druet P., Mandet C. Induction of susceptibility to HgCl2 immune glomerulonephritis in the Lewis rat by immunocompetent cells from susceptible F1 hybrids. Eur J Immunol. 1980 May;10(5):371–374. doi: 10.1002/eji.1830100510. [DOI] [PubMed] [Google Scholar]
  16. Stenglein B., Thoenes G. H., Günther E. Genetically controlled autologous immune complex glomerulonephritis in rats. J Immunol. 1975 Oct;115(4):895–897. [PubMed] [Google Scholar]
  17. Williams R. M., Moore M. J. Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in the rat. J Exp Med. 1973 Oct 1;138(4):775–783. doi: 10.1084/jem.138.4.775. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES