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. 1982 Jun;48(3):513–518.

Defective B cell function in systemic lupus erythematosus.

B K Pelton, A M Denman
PMCID: PMC1536611  PMID: 6981471

Abstract

The in vitro synthesis of specific anti-influenza virus antibody was measured in cultures of peripheral blood lymphocytes from 25 patients with systemic lupus erythematosus (SLE) and 23 control subjects. Whilst all cultures derived from normal individuals synthesized specific antibody, cultures from patients with SLE were consistently unable to produce anti-influenza antibody. This defect could not be corrected by manipulating the culture conditions or by in vivo immunization. Co-cultivation of separated SLE-B or control B cells, with SLE-T or control T cells showed that the immunodeficiency exhibited by the SLE peripheral blood lymphocytes resides in the B cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baum J., Ziff M. Decreased 19S antibody response to bacterial antigens in systemic lupus erythematosus. J Clin Invest. 1969 Apr;48(4):758–767. doi: 10.1172/JCI106033. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bentwich Z., Douglas S. D., Skutelsky E., Kunkel H. G. Sheep red cell binding to human lymphocytes treated with neuraminidase; enhancement of T cell binding and identification of a subpopulation of B cells. J Exp Med. 1973 Jun 1;137(6):1532–1537. doi: 10.1084/jem.137.6.1532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bobrove A. M., Miller P. Depressed in vitro B-lymphocyte differentiation in systemic lupus erythematosus. Arthritis Rheum. 1977 Sep-Oct;20(7):1326–1333. doi: 10.1002/art.1780200705. [DOI] [PubMed] [Google Scholar]
  4. Bresnihan B., Jasin H. E. Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J Clin Invest. 1977 Jan;59(1):106–116. doi: 10.1172/JCI108607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Budman D. R., Merchant E. B., Steinberg A. D., Doft B., Gershwin M. E., Lizzio E., Reeves J. P. Increased spontaneous activity of antibody-forming cells in the peripheral blood of patients with active SLE. Arthritis Rheum. 1977 Apr;20(3):829–833. doi: 10.1002/art.1780200312. [DOI] [PubMed] [Google Scholar]
  6. Callard R. E. Specific in vitro antibody response to influenza virus by human blood lymphocytes. Nature. 1979 Dec 13;282(5740):734–736. doi: 10.1038/282734a0. [DOI] [PubMed] [Google Scholar]
  7. Delfraissy J. F., Segond P., Galanaud P., Wallon C., Massias P., Dormont J. Depressed primary in vitro antibody response in untreated systemic lupus erythematosus. T helper cell defect and lack of defective suppressor cell function. J Clin Invest. 1980 Jul;66(1):141–148. doi: 10.1172/JCI109827. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fauci A. S., Steinberg A. D., Haynes B. F., Whalen G. Immunoregulatory aberrations in systemic lupus erythematosus. J Immunol. 1978 Oct;121(4):1473–1479. [PubMed] [Google Scholar]
  9. Ginsburg W. W., Finkelman F. D., Lipsky P. E. Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus. Clin Exp Immunol. 1979 Jan;35(1):76–88. [PMC free article] [PubMed] [Google Scholar]
  10. Hersey P., Edwards A., Edwards J. Characterization of mononuclear effector cells in human blood. Clin Exp Immunol. 1976 Jan;23(1):104–113. [PMC free article] [PubMed] [Google Scholar]
  11. Messner R. P., Lindström F. D., Williams R. C., Jr Peripheral blood lymphocyte cell surface markers during the course of systemic lupus erythematosus. J Clin Invest. 1973 Dec;52(12):3046–3056. doi: 10.1172/JCI107503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Morimoto C., Abe T., Hara M., Homma M. In vitro TNP-specific antibody formation by peripheral lymphocytes from patients with systemic lupus erythematosus. Scand J Immunol. 1977;6(6-7):575–579. doi: 10.1111/j.1365-3083.1977.tb02135.x. [DOI] [PubMed] [Google Scholar]
  13. Nies K. M., Louie J. S. Impaired immunoglobulin synthesis by peripheral blood lymphocytes in systemic lupus erythematosus. Arthritis Rheum. 1978 Jan-Feb;21(1):51–57. doi: 10.1002/art.1780210109. [DOI] [PubMed] [Google Scholar]
  14. Pelton B. K., Imrie R. C., Denman A. M. Susceptibility of human lymphocyte populations to infection by herpes simplex virus. Immunology. 1977 May;32(5):803–810. [PMC free article] [PubMed] [Google Scholar]
  15. Pincus T., Steinberg A. D., Blacklow N. R., Decker J. L. Reactivities of systemic lupus erythematosus sera with cellular and virus antigen preparations. Arthritis Rheum. 1978 Nov-Dec;21(8):873–879. doi: 10.1002/art.1780210801. [DOI] [PubMed] [Google Scholar]
  16. Ristow S. C., Douglas R. G., Jr, Condemi J. J. Influenza vaccination of patients with systemic lupus erythematosus. Ann Intern Med. 1978 Jun;88(6):786–789. doi: 10.7326/0003-4819-88-6-786. [DOI] [PubMed] [Google Scholar]
  17. Souhami R. L., Babbage J., Callard R. E. Specific in vitro antibody response to varicella zoster. Clin Exp Immunol. 1981 Oct;46(1):98–105. [PMC free article] [PubMed] [Google Scholar]
  18. Talal N. Disordered immunologic regulation and autoimmunity. Transplant Rev. 1976;31:240–263. doi: 10.1111/j.1600-065x.1976.tb01456.x. [DOI] [PubMed] [Google Scholar]
  19. Tan P., Pang G., Wilson J. D. Immunoglobulin production in vitro by peripheral blood lymphocytes in systemic lupus erythematosus: helper T cell defect and B cell hyperreactivity. Clin Exp Immunol. 1981 Jun;44(3):548–554. [PMC free article] [PubMed] [Google Scholar]
  20. Williams G. W., Steinberg A. D., Reinertsen J. L., Klassen L. W., Decker J. L., Dolin R. Influenza immunization in systemic lupus eruthematosus. A double-blind trial. Ann Intern Med. 1978 Jun;88(6):729–734. doi: 10.7326/0003-4819-88-6-729. [DOI] [PubMed] [Google Scholar]

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