Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1982 Jun;48(3):551–554.

Antibodies in serum and secretions 1 year after salmonella gastroenteritis.

J T La Brooy, D J Shearman, D Rowley
PMCID: PMC1536619  PMID: 7116685

Abstract

The antibody response in serum and intestinal fluid in eight patients 1 year after their recovery from salmonella gastroenteritis was measured by solid phase radioimmunoassay and compared to the immune response within a few weeks of infection, reported previously in these and other patients. High concentrations of intestinal antibody were found in six patients compared to the concentrations found in 10 control subjects. By contrast the serum antibody concentration in the patients was only marginally higher than in the controls. The use of IgA and IgG specific antisera in the assay confirmed the presence of IgA antibody in the absence of IgG antibody in the gastrointestinal secretions, and the predominance of IgG antibody in the serum. The prolonged immune response in the gut after acute bacterial gastroenteritis supports the possibility of effective immunization against diseases entering via the gut.

Full text

PDF
551

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cash R. A., Music S. I., Libonati J. P., Craig J. P., Pierce N. F., Hornick R. B. Response of man to infection with Vibrio cholerae. II. Protection from illness afforded by previous disease and vaccine. J Infect Dis. 1974 Oct;130(4):325–333. doi: 10.1093/infdis/130.4.325. [DOI] [PubMed] [Google Scholar]
  2. Challacombe S. J., Tomasi T. B., Jr Systemic tolerance and secretory immunity after oral immunization. J Exp Med. 1980 Dec 1;152(6):1459–1472. doi: 10.1084/jem.152.6.1459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Elson C. O., Heck J. A., Strober W. T-cell regulation of murine IgA synthesis. J Exp Med. 1979 Mar 1;149(3):632–643. doi: 10.1084/jem.149.3.632. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FRETER R., DE S. P., MONDAL A., SHRIVASTAVA D. L., SUNDERMAN F. W., Jr COPROANTIBODY AND SERUM ANTIBODY IN CHOLERA PATIENTS. J Infect Dis. 1965 Feb;115:83–87. doi: 10.1093/infdis/115.1.83. [DOI] [PubMed] [Google Scholar]
  5. La Brooy J. T., Davidson G. P., Sherman D. J., Rowley D. The antibody response to bacterial gastroenteritis in serum and secretions. Clin Exp Immunol. 1980 Aug;41(2):290–296. [PMC free article] [PubMed] [Google Scholar]
  6. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  7. McNeish A. S., Evans N., Gaze H., Rogers K. B. The agglutinating antibody response in the duodenum in infants with enteropathic E. coli gastroenteritis. Gut. 1975 Sep;16(9):727–731. doi: 10.1136/gut.16.9.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Reed W. P., Williams R. C., Jr Intestinal immunoglobulins in shigellosis. Gastroenterology. 1971 Jul;61(1):35–45. [PubMed] [Google Scholar]
  9. Waldman R. H., Bencic Z., Sinha R., Deb B. C., Sakazaki R., Tamura K., Mukerjee S., Ganguly R. Cholera immunology. II. Serum and intestinal secretion antibody response after naturally occurring cholera. J Infect Dis. 1972 Oct;126(4):401–407. doi: 10.1093/infdis/126.4.401. [DOI] [PubMed] [Google Scholar]
  10. Zollinger W. D., Dalrymple J. M., Artenstein M. S. Analysis of parameters affecting the solid phase radioimmunoassay quantitation of antibody to meningococcal antigens. J Immunol. 1976 Nov;117(5 PT2):1788–1798. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES