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. 1982 Jul;49(1):157–162.

Imbalance of T cell subpopulations in patients with chronic lymphocytic leukaemia of the B cell type.

F Herrmann, A Lochner, H Philippen, B Jauer, H Rühl
PMCID: PMC1536649  PMID: 6982129

Abstract

T cell enriched mononuclear cells from the peripheral blood of 20 patients with histologically and immunologically defined chronic lymphocytic leukaemia of the B cell type (B-CLL) and 20 healthy individuals of various ages were investigated with T cell-specific monoclonal antibodies (OKT 4 and OKT 8) with regard to their subpopulation distribution. In B-CLL, a significant increase of lymphocytes reacting with OKT 8 could be demonstrated. Whereas there was a ratio of OKT 4 to OKT 8 of 1 X 72 in the control group, an OKT 4 to OKT 8 ratio of 0 X 67 was found in the B-CLL as a whole. With increasing clinical stage in accordance with the Rai scheme (Rai et al., 1975), a further displacement of this ratio in favour of OKT 8 positive cells was found. These results clearly show that, in peripheral blood of patients with B-CLL, an abnormal distribution pattern of circulating T cell subpopulations is present and that this also has prognostic relevance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach M. A., Bach J. F. The use of monoclonal anti-T cell antibodies to study T cell imbalances in human diseases. Clin Exp Immunol. 1981 Sep;45(3):449–456. [PMC free article] [PubMed] [Google Scholar]
  2. Billing R., Rafizadeh B., Drew I., Hartman G., Gale R., Terasaki P. Human B-lymphocyte antigens expressed by lymphocytic and myelocytic leukemia cells. I. Detection by rabbit antisera. J Exp Med. 1976 Jul 1;144(1):167–178. doi: 10.1084/jem.144.1.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Catovsky D., Miliani E., Okos A., Galton D. A. Clinical significance of T-cells in chronic lymphocytic leukaemia. Lancet. 1974 Sep 28;2(7883):751–752. doi: 10.1016/s0140-6736(74)90944-1. [DOI] [PubMed] [Google Scholar]
  4. Dameshek W. Chronic lymphocytic leukemia--an accumulative disease of immunolgically incompetent lymphocytes. Blood. 1967 Apr;29(4 Suppl):566–584. [PubMed] [Google Scholar]
  5. Foa R., Catovsky D., Brozovic M., Marsh G., Ooyirilangkumaran T., Cherchi M., Galton D. A. Clinical staging and immunological findings in chronic lymphocytic leukemia. Cancer. 1979 Aug;44(2):483–487. doi: 10.1002/1097-0142(197908)44:2<483::aid-cncr2820440217>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  6. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kay N. E., Johnson J. D., Stanek R., Douglas S. D. T-cell subpopulations in chronic lymphocytic leukemia: abnormalities in distribtuion and in in vitro receptor maturation. Blood. 1979 Aug;54(2):540–544. [PubMed] [Google Scholar]
  8. Kung P., Goldstein G., Reinherz E. L., Schlossman S. F. Monoclonal antibodies defining distinctive human T cell surface antigens. Science. 1979 Oct 19;206(4416):347–349. doi: 10.1126/science.314668. [DOI] [PubMed] [Google Scholar]
  9. Lauria F., Foa R., Catovsky D. Increase in T gamma lymphocytes in B-cell chronic lymphocytic leukaemia. Scand J Haematol. 1980 Feb;24(2):187–190. doi: 10.1111/j.1600-0609.1980.tb02366.x. [DOI] [PubMed] [Google Scholar]
  10. MILLER D. G., KARNOFSKY D. A. Immunologic factors and resistance to infection in chronic lymphatic leukemia. Am J Med. 1961 Nov;31:748–757. doi: 10.1016/0002-9343(61)90159-0. [DOI] [PubMed] [Google Scholar]
  11. Moretta L., Mingari M. C., Webb S. R., Pearl E. R., Lydyard P. M., Grossi C. E., Lawton A. R., Cooper M. D. Imbalances in T cell subpopulations associated with immunodeficiency and autoimmune syndromes. Eur J Immunol. 1977 Oct;7(10):696–700. doi: 10.1002/eji.1830071009. [DOI] [PubMed] [Google Scholar]
  12. Pincus S., Bianco C., Nussenzweig V. Increased proportion of complement-receptor lymphocytes in the peripheral blood of patients with chronic lymphocytic leukemia. Blood. 1972 Sep;40(3):303–310. [PubMed] [Google Scholar]
  13. Rabellino E., Colon S., Grey H. M., Unanue E. R. Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation. J Exp Med. 1971 Jan 1;133(1):156–167. doi: 10.1084/jem.133.1.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rai K. R., Sawitsky A., Cronkite E. P., Chanana A. D., Levy R. N., Pasternack B. S. Clinical staging of chronic lymphocytic leukemia. Blood. 1975 Aug;46(2):219–234. [PubMed] [Google Scholar]
  15. Reinherz E. L., Kung P. C., Goldstein G., Levey R. H., Schlossman S. F. Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1588–1592. doi: 10.1073/pnas.77.3.1588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rühl H., Scholle H., Bochert G., Vogt W. Activation of lymphocyte subpopulations in patients with chronic lymphocytic leukemia. Z Immunitatsforsch Immunobiol. 1978;154(1):75–87. [PubMed] [Google Scholar]
  17. Salmon S. E., Seligmann M. B-cell neoplasia in man. Lancet. 1974 Nov 23;2(7891):1230–1233. doi: 10.1016/s0140-6736(74)90748-x. [DOI] [PubMed] [Google Scholar]
  18. Stathopoulos G., Elliott E. V. Formation of mouse or sheep red-blood-cell rosettes by lymphocytes from normal and leukaemic individuals. Lancet. 1974 Apr 6;1(7858):600–601. doi: 10.1016/s0140-6736(74)92655-5. [DOI] [PubMed] [Google Scholar]
  19. Thomas Y., Sosman J., Irigoyen O., Friedman S. M., Kung P. C., Goldstein G., Chess L. Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative T-T interactions in the immunoregulation of B cell differentiation. J Immunol. 1980 Dec;125(6):2402–2408. [PubMed] [Google Scholar]
  20. Waldmann T. A., Blaese R. M., Broder S., Krakauer R. S. Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity. Ann Intern Med. 1978 Feb;88(2):226–238. doi: 10.7326/0003-4819-88-2-226. [DOI] [PubMed] [Google Scholar]
  21. Wybran J., Chantler S., Fudenberg H. H. Isolation of normal T cells in chronic lymphatic leukaemia. Lancet. 1973 Jan 20;1(7795):126–129. doi: 10.1016/s0140-6736(73)90196-7. [DOI] [PubMed] [Google Scholar]

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