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. 1982 Jul;49(1):233–238.

The effect of salicylate on human leucocyte migration.

A S Kemp, J Smith
PMCID: PMC1536655  PMID: 6181922

Abstract

The effect of sodium salicylate, at concentrations obtained in vivo, on the random migration and chemotactic response of neutrophils and monocytes was examined. Incubation of cells in vitro increased neutrophil migration but decreased monocyte migration. However, both neutrophil and monocyte migration were significantly increased when obtained from normal individuals after ingestion of sodium salicylate. Salicylate also partly reversed the inhibition of neutrophil migration produced by aggregated immunoglobulin bound to the filter substrate. These effects of salicylate on leucocyte function may contribute to the anti-inflammatory activity of the drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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