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. 1982 Sep;49(3):500–508.

Suppressed natural killer cell activity during episodes of erythema nodosum leprosum in lepromatous leprosy.

R C Humphres, R H Gelber, J L Krahenbuhl
PMCID: PMC1536721  PMID: 7172493

Abstract

Natural killer (NK) cell activity was investigated in peripheral blood mononuclear cells of patients with leprosy. The NK activity of patients with borderline or lepromatous leprosy did not differ significantly from that of normal subjects. However, in a group of patients with lepromatous leprosy undergoing an episode of erythema nodosum leprosum (ENL), NK activity was significantly depressed. In four patients with ENL, NK activity was virtually abolished. Depressed NK activity could not be attributed to the effects of corticosteroid therapy, nor did a serum factor appear to be responsible. Evidence was obtained that depressed NK activity in patients with ENL was not due to dysfunction of the NK cells themselves; they functioned normally when separated from the individual's total mononuclear cell population. Additional cell depletion studies suggested that the patients' monocytes were responsible for the observed depression of NK activity.

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Selected References

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  1. BROWNE S. G. Erythema nodosum in leprosy. J Chronic Dis. 1963 Jan;16:23–30. doi: 10.1016/0021-9681(63)90017-1. [DOI] [PubMed] [Google Scholar]
  2. Bjorvatn B., Barnetson R. S., Kronvall G., Zubler R. H., Lambert P. H. Immune complexes and complement hypercatabolism in patients with leprosy. Clin Exp Immunol. 1976 Dec;26(3):388–396. [PMC free article] [PubMed] [Google Scholar]
  3. Bullock W. E., Jr, Fasal P. Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response. J Immunol. 1971 Apr;106(4):888–899. [PubMed] [Google Scholar]
  4. Cudkowicz G., Hochman P. S. Do natural killer cells engage in regulated reactions against self to ensure homeostasis? Immunol Rev. 1979;44:13–41. doi: 10.1111/j.1600-065x.1979.tb00266.x. [DOI] [PubMed] [Google Scholar]
  5. Gidlund M., Orn A., Wigzell H., Senik A., Gresser I. Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature. 1978 Jun 29;273(5665):759–761. doi: 10.1038/273759a0. [DOI] [PubMed] [Google Scholar]
  6. Haliotis T., Roder J., Klein M., Ortaldo J., Fauci A. S., Herberman R. B. Chédiak-Higashi gene in humans I. Impairment of natural-killer function. J Exp Med. 1980 May 1;151(5):1039–1048. doi: 10.1084/jem.151.5.1039. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hersey P., Edwards A., Honeyman M., McCarthy W. H. Low natural-killer-cell activity in familial melanoma patients and their relatives. Br J Cancer. 1979 Jul;40(1):113–122. doi: 10.1038/bjc.1979.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. JOB C. K., GUDE S., MACADEN V. P. ERYTHEMA NODOSUM LEPROSUM. A CLINICO-PATHOLOGIC STUDY. Int J Lepr. 1964 Apr-Jun;32:177–184. [PubMed] [Google Scholar]
  9. Koren H. S., Amos D. B., Buckley R. H. Natural killing in immunodeficient patients. J Immunol. 1978 Mar;120(3):796–799. [PubMed] [Google Scholar]
  10. Moran C. J., Ryder G., Turk J. L., Waters M. F. Evidence for circulating immune complexes in lepromatous leprosy. Lancet. 1972 Sep 16;2(7777):572–573. doi: 10.1016/s0140-6736(72)91962-9. [DOI] [PubMed] [Google Scholar]
  11. Myrvang B., Godal T., Ridley D. S., Fröland S. S., Song Y. K. Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. Clin Exp Immunol. 1973 Aug;14(4):541–553. [PMC free article] [PubMed] [Google Scholar]
  12. Oshimi K., Gonda N., Sumiya M., Kano S. Effects of corticosteroids on natural killer cell activity in systemic lupus erythematosus. Clin Exp Immunol. 1980 Apr;40(1):83–88. [PMC free article] [PubMed] [Google Scholar]
  13. Parrillo J. E., Fauci A. S. Comparison of the effector cells in human spontaneous cellular cytotoxicity and antibody-dependent cellular cytotoxicity: differential sensitivity of effector cells to in vivo and in vitro corticosteroids. Scand J Immunol. 1978;8(2):99–107. doi: 10.1111/j.1365-3083.1978.tb00501.x. [DOI] [PubMed] [Google Scholar]
  14. Pross H. F., Gupta S., Good R. A., Baines M. G. Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. VII. The effect of immunodeficiency disease. Cell Immunol. 1979 Mar 1;43(1):160–175. doi: 10.1016/0008-8749(79)90159-x. [DOI] [PubMed] [Google Scholar]
  15. Rea T. H., Quismorio F. P., Harding B., Nies K. M., Di Saia P. J., Levan N. E., Friou G. J. Immunologic responses in patients with lepromatous leprosy. Arch Dermatol. 1976 Jun;112(6):791–800. [PubMed] [Google Scholar]
  16. Ridley D. S., Jopling W. H. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966 Jul-Sep;34(3):255–273. [PubMed] [Google Scholar]
  17. Ridley D. S. Reactions in leprosy. Lepr Rev. 1969 Apr;40(2):77–81. doi: 10.5935/0305-7518.19690016. [DOI] [PubMed] [Google Scholar]
  18. Rosenberg E. B., McCoy J. L., Green S. S., Donnelly F. C., Siwarski D. F., Levine P. H., Herberman R. B. Destruction of human lymphoid tissue-culture cell lines by human peripheral lymphocytes in 51Cr-release cellular cytotoxicity assays. J Natl Cancer Inst. 1974 Feb;52(2):345–352. doi: 10.1093/jnci/52.2.345. [DOI] [PubMed] [Google Scholar]
  19. Silverman S. L., Cathcart E. S. Natural killing in systemic lupus erythematosus: inhibitory effects of serum. Clin Immunol Immunopathol. 1980 Oct;17(2):219–226. doi: 10.1016/0090-1229(80)90090-2. [DOI] [PubMed] [Google Scholar]
  20. Takasugi M., Ramseyer A., Takasugi J. Decline of natural nonselective cell-mediated cytotoxicity in patients with tumor progression. Cancer Res. 1977 Feb;37(2):413–418. [PubMed] [Google Scholar]
  21. Timonen T., Saksela E. Isolation of human NK cells by density gradient centrifugation. J Immunol Methods. 1980;36(3-4):285–291. doi: 10.1016/0022-1759(80)90133-7. [DOI] [PubMed] [Google Scholar]
  22. Waldorf D. S., Sheagren J. N., Trautman J. R., Block J. B. Impaired delayed hypersensitivity in patients with lepromatous leprosy. Lancet. 1966 Oct 8;2(7467):773–776. doi: 10.1016/s0140-6736(66)90366-7. [DOI] [PubMed] [Google Scholar]
  23. Waters M. F., Turk J. L., Wemambu S. N. Mechanisms of reactions in leprosy. Int J Lepr Other Mycobact Dis. 1971 Apr-Jun;39(2):417–428. [PubMed] [Google Scholar]
  24. Wemambu S. N., Turk J. L., Waters M. F., Rees R. J. Erythema nodosum leprosum: a clinical manifestation of the arthus phenomenon. Lancet. 1969 Nov 1;2(7627):933–935. doi: 10.1016/s0140-6736(69)90592-3. [DOI] [PubMed] [Google Scholar]
  25. Yam L. T., Li C. Y., Crosby W. H. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971 Mar;55(3):283–290. doi: 10.1093/ajcp/55.3.283. [DOI] [PubMed] [Google Scholar]

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