Abstract
Normally there is autoreactivity between subpopulations of lymphocytes. T lymphocytes respond to autologous non-T lymphocytes in co-culture by proliferation. In this study, we provide data to demonstrate that alloantigen primed peripheral blood lymphocytes (PBL) from individuals of certain HLA types respond to autologous PBL in the primed lymphocyte test (PLT). This autoreactivity in PLT was found to be associated with HLA-B8/DR3 alloantigens.
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Selected References
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- Bergholtz B., Albrechtsen D., Thorsby E. Stimulation of T lymphocytes by autologous non-T lymphoid cells. Participation of HLA-D? Tissue Antigens. 1977 Jul;10(1):27–38. doi: 10.1111/j.1399-0039.1977.tb00748.x. [DOI] [PubMed] [Google Scholar]
- Böyum A. Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. Scand J Clin Lab Invest Suppl. 1968;97:31–50. [PubMed] [Google Scholar]
- Hausman P. B., Stobo J. D. Specificity and function of a human autologous reactive T cell. J Exp Med. 1979 Jun 1;149(6):1537–1542. doi: 10.1084/jem.149.6.1537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuntz M. M., Innes J. B., Weksler M. E. Lymphocyte transformation induced by autologous cells. IV. Human T-lymphocyte proliferation induced by autologous or allogeneic non-T lymphocytes. J Exp Med. 1976 May 1;143(5):1042–1054. doi: 10.1084/jem.143.5.1042. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lawley T. J., Hall R. P., Fauci A. S., Katz S. I., Hamburger M. I., Frank M. M. Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects. N Engl J Med. 1981 Jan 22;304(4):185–192. doi: 10.1056/NEJM198101223040401. [DOI] [PubMed] [Google Scholar]
- Mason D. W., Pugh C. W., Webb M. The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies. Immunology. 1981 Sep;44(1):75–87. [PMC free article] [PubMed] [Google Scholar]
- Mickelson E. M., Clift R. A., Fefer A., Storb R., Thomas E. D., Warren R. P., Hansen J. A. Studies of the response in mixed leukocyte culture of cells from patients with aplastic anemia to cells from HLA-identical siblings. Transplantation. 1981 Aug;32(2):90–95. doi: 10.1097/00007890-198108000-00002. [DOI] [PubMed] [Google Scholar]
- Opelz G., Kiuchi M., Takasugi M., Terasaki P. I. Autologous stimulation of human lymphocyte subpopulation. J Exp Med. 1975 Nov 1;142(5):1327–1333. doi: 10.1084/jem.142.5.1327. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Plate J. M., McKenzie I. F. "B"-cell stimulation of allogeneic T-cell proliferation in mixed lymphocyte cultures. Nat New Biol. 1973 Oct 24;245(147):247–249. doi: 10.1038/newbio245247a0. [DOI] [PubMed] [Google Scholar]
- Sheehy M. J. Primed lymphocyte typing (PLT): dichtomizing responses into "positives" and "negatives". Tissue Antigens. 1978 Feb;11(2):87–95. doi: 10.1111/j.1399-0039.1978.tb01232.x. [DOI] [PubMed] [Google Scholar]
- Singal D. P. Genetics of responses of alloantigen primed lymphocytes in secondary MLC. Transplant Proc. 1978 Dec;10(4):771–774. [PubMed] [Google Scholar]
- Smith J. B., Knowlton R. P. Activation of suppressor T cells in human autologous mixed lymphocyte culture. J Immunol. 1979 Jul;123(1):419–422. [PubMed] [Google Scholar]
- Smith J. B. Stimulation of autologous and allogeneic human T cells by B cells occurs through separate B-cell antigen systems. Cell Immunol. 1978 Mar 15;36(2):203–209. doi: 10.1016/0008-8749(78)90264-2. [DOI] [PubMed] [Google Scholar]
- Steinman R. M., Nussenzweig M. C. Dendritic cells: features and functions. Immunol Rev. 1980;53:127–147. doi: 10.1111/j.1600-065x.1980.tb01042.x. [DOI] [PubMed] [Google Scholar]
- Terasaki P. I., Bernoco D., Park M. S., Ozturk G., Iwaki Y. Microdroplet testing for HLA-A, -B, -C, and -D antigens. The Phillip Levine Award Lecture. Am J Clin Pathol. 1978 Feb;69(2):103–120. doi: 10.1093/ajcp/69.2.103. [DOI] [PubMed] [Google Scholar]
- Weksler M. E., Kozak R. Lymphocyte transformation induced by autologous cells. V. Generation of immunologic memory and specificity during the autologous mixed lymphocyte reaction. J Exp Med. 1977 Dec 1;146(6):1833–1838. doi: 10.1084/jem.146.6.1833. [DOI] [PMC free article] [PubMed] [Google Scholar]
