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. 1983 Jan;51(1):117–125.

Role of T lymphocytes in collagen II-induced arthritis in rats

L Klareskog, R Holmdahl, E Larsson, H Wigzell
PMCID: PMC1536759  PMID: 6219836

Abstract

The role of T lymphocytes in collagen II induced arthritis in rats has been investigated. Functional T cells were needed for the development of arthritis since none out of 14 nude rats injected with collagen type II developed arthritis, whereas 11 out of 14 of their normal counterparts did. With the help of antibodies specific for Ia antigens and different T cell subsets in the rats, an immunohistochemical method was used to demonstrate that T cells, predominantly of `helper' type and anti-Ia reactive non-T cells were abundant in the arthritic synovial tissue.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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