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. 1983 Mar;51(3):487–493.

T-independent macrophage changes in murine malaria.

R Lelchuk, H M Dockrell, J H Playfair
PMCID: PMC1536773  PMID: 6342882

Abstract

A study to investigate the participation of T cells in macrophage-mediated responses during malaria was performed in nude (nu/nu) and littermate (nu/+) mice infected with Plasmodium berghei (PB). We found that in both groups of mice spleen cells suppressed the mitogenic response to LPS. Both nu/+ and nu/nu infected mice also showed liver macrophage activation, reflected by increased plasminogen activator release. These findings suggest that at least some of the macrophage changes during malaria infection are T-independent.

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Selected References

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