Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1983 Mar;51(3):624–630.

Changes in serum IgD in cigarette smokers.

S L Bahna, D C Heiner, B A Myhre
PMCID: PMC1536788  PMID: 6851250

Abstract

Serum IgD levels in 83 healthy adults were measured by a radioimmunoassay technique and analysed according to each subject's smoking habit. The IgD geometric mean in cigarette smokers was twice as high as in non-smokers (408.6 vs 202.0 micrograms/dl). Serum IgD levels of 1,000 micrograms/dl or greater were noted in 22% of smokers but in none of the rare smokers or non-smokers. In the smokers group, the highest mean IgD level was found in those who did not actively inhale the smoke (762.6 micrograms/dl), followed by that in moderate smokers (563.8 micrograms/dl), and was lowest in heavy smokers who inhaled the smoke (283.0 micrograms/dl). The number of years a person smoked did not appear to have a significant effect on IgD levels. In ex-smokers, the mean IgD level (199.8 micrograms/dl) was similar to that in non-smokers, suggesting reversibility of the IgD changes following cessation of smoking. It seems prudent that the smoking habit should be taken into consideration in the interpretation of serum IgD levels.

Full text

PDF
624

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bahna S. L., Keller M. A., Heiner D. C. IgE and IgD in human colostrum and plasma. Pediatr Res. 1982 Aug;16(8):604–607. doi: 10.1203/00006450-198208000-00004. [DOI] [PubMed] [Google Scholar]
  2. Bahna S. L., Tateno K., Heiner D. C. Elevated IgD antibodies to wheat in celiac disease. Ann Allergy. 1980 Mar;44(3):146–151. [PubMed] [Google Scholar]
  3. Burrows B., Halonen M., Barbee R. A., Lebowitz M. D. The relationship of serum immunoglobulin E to cigarette smoking. Am Rev Respir Dis. 1981 Nov;124(5):523–525. doi: 10.1164/arrd.1981.124.5.523. [DOI] [PubMed] [Google Scholar]
  4. Dales L. G., Friedman G. D., Siegelaub A. B., Seltzer C. C. Cigarette smoking and serum chemistry tests. J Chronic Dis. 1974 Aug;27(6):293–307. doi: 10.1016/0021-9681(74)90093-9. [DOI] [PubMed] [Google Scholar]
  5. Dresser D. W., Parkhouse R. M. The effect of the parenteral administration of a rabbit anti-(mouse)-IgD serum on the immune response of mice to sheep erythrocytes. Immunology. 1978 Dec;35(6):1027–1036. [PMC free article] [PubMed] [Google Scholar]
  6. Dunnette S. L., Gleich G. J., Miller R. D., Kyle R. A. Measurement of IgD by a double antibody radioimmunoassay: demonstration of an apparent trimodal distribution of IgD levels in normal human sera. J Immunol. 1977 Nov;119(5):1727–1731. [PubMed] [Google Scholar]
  7. Gerrard J. W., Heiner D. C., Ko C. G., Mink J. T., Myers A. IgD levels in white and Metis communities in Saskatchewan. Ann Allergy. 1981 Jun;46(6):321–324. [PubMed] [Google Scholar]
  8. Gerrard J. W., Heiner D. C., Ko C. G., Mink J., Meyers A., Dosman J. A. Immunoglobulin levels in smokers and non-smokers. Ann Allergy. 1980 May;44(5):261–262. [PubMed] [Google Scholar]
  9. Gulsvik A., Fagerhoi M. K. Smoking and immunoglobulin levels. Lancet. 1979 Feb 24;1(8113):449–449. doi: 10.1016/s0140-6736(79)90934-6. [DOI] [PubMed] [Google Scholar]
  10. Jacob C. V., Stelzer G. T., Wallace J. H. The influence of cigarette tobacco smoke products on the immune response. The cellular basis of immunosuppression by a water-soluble condensate of tobacco smoke. Immunology. 1980 Aug;40(4):621–627. [PMC free article] [PubMed] [Google Scholar]
  11. Josephs S. H., Buckley R. H. Serum IgD concentrations in normal infants, children, and adults and in patients with elevated IgE. J Pediatr. 1980 Mar;96(3 Pt 1):417–420. doi: 10.1016/s0022-3476(80)80684-6. [DOI] [PubMed] [Google Scholar]
  12. Kośmider S., Feluś E., Wysocki J. Ocena niektórych wyznaczników odporności humoralnej u palaczy papierosów. Pol Tyg Lek. 1973 Jan 8;28(2):47–50. [PubMed] [Google Scholar]
  13. Lee S. K., Metrakos J. D., Tanaka K. R., Heiner D. C. Genetic influence on serum igd levels. Pediatr Res. 1980 Jan;14(1):60–63. doi: 10.1203/00006450-198001000-00014. [DOI] [PubMed] [Google Scholar]
  14. Lee W. Y., Heiner D. C. Preparation of rabbit anti-IgE for use in radioimmunoassays of total IgE and specific IgE antibodies. J Immunol Methods. 1978;20:185–200. doi: 10.1016/0022-1759(78)90255-7. [DOI] [PubMed] [Google Scholar]
  15. Lertora J. J., Gomez-Perez F. J., Leslie G. A. Structure and biological functions of human IgD. V. Insulin antibodies of the IgD class in sera from some diabetic patients. Int Arch Allergy Appl Immunol. 1975;49(5):597–606. doi: 10.1159/000231441. [DOI] [PubMed] [Google Scholar]
  16. Meyer D. H., Cross C. E., Ibrahim A. B., Mustafa M. G. Nicotine effects on alveolar macrophage respiration and adenosine triphosphatase activity. Arch Environ Health. 1971 Mar;22(3):362–365. doi: 10.1080/00039896.1971.10665855. [DOI] [PubMed] [Google Scholar]
  17. Nordbring F., Högman C., Johansson S. G. Serum immunoglobulin levels in the course of acute pneumonia. Scand J Infect Dis. 1969;1(2):99–106. doi: 10.3109/inf.1969.1.issue-2.05. [DOI] [PubMed] [Google Scholar]
  18. ROWE D. S., FAHEY J. L. A NEW CLASS OF HUMAN IMMUNOGLOBULINS. II. NORMAL SERUM IGD. J Exp Med. 1965 Jan 1;121:185–199. doi: 10.1084/jem.121.1.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rogentine G. N., Jr, Rowe D. S., Bradley J., Waldmann T. A., Fahey J. L. Metabolism of human immunoglobulin D (IgD). J Clin Invest. 1966 Sep;45(9):1467–1478. doi: 10.1172/JCI105454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Roszman T. L., Elliott L. H., Rogers A. S. Suppression of lymphocyte function by products derived from cigarette smoke. Am Rev Respir Dis. 1975 Apr;111(4):453–457. doi: 10.1164/arrd.1975.111.4.453. [DOI] [PubMed] [Google Scholar]
  21. Rowe D. S., Crabbé P. A., Turner M. W. Immunoglobulin D in serum, body fluids and lymphoid tissues. Clin Exp Immunol. 1968 Jul;3(6):477–490. [PMC free article] [PubMed] [Google Scholar]
  22. Sewell H. F., Chambers L., Maxwell V., Matthews J. B., Jefferis R. The natural antibody response to E. coli includes antibodies of the IgD class. Clin Exp Immunol. 1978 Jan;31(1):104–110. [PMC free article] [PubMed] [Google Scholar]
  23. Stedman R. L. The chemical composition of tobacco and tobacco smoke. Chem Rev. 1968 Apr;68(2):153–207. doi: 10.1021/cr60252a002. [DOI] [PubMed] [Google Scholar]
  24. Suciu-Foca N., Molinaro A., Buda J., Reemtsma K. Letter: Cellular immune responsiveness in cigarette smokers. Lancet. 1974 May 25;1(7865):1062–1062. doi: 10.1016/s0140-6736(74)90474-7. [DOI] [PubMed] [Google Scholar]
  25. THAYER P. S., KENSLER C. J. CIGARETTE SMOKE: CHARCOAL FILTERS REDUCE COMPONENTS THAT INHIBIT GROWTH OF CULTURED HUMAN CELLS. Science. 1964 Oct 30;146(3644):642–644. doi: 10.1126/science.146.3644.642. [DOI] [PubMed] [Google Scholar]
  26. Thomas W. R., Holt P. G., Keast D. Development of alterations in the primary immune response of mice by exposure to fresh cigarette smoke. Int Arch Allergy Appl Immunol. 1974;46(4):481–486. doi: 10.1159/000231151. [DOI] [PubMed] [Google Scholar]
  27. Thomas W. R., Holt P. G., Keast D. Recovery of immune system after cigarette smoking. Nature. 1974 Mar 22;248(446):358–359. doi: 10.1038/248358a0. [DOI] [PubMed] [Google Scholar]
  28. Vitetta E. S., Uhr J. W. Immunoglobulin-receptors revisited. Science. 1975 Sep 19;189(4207):964–969. doi: 10.1126/science.1083069. [DOI] [PubMed] [Google Scholar]
  29. Warren C. P., Holford-Strevens V., Wong C., Manfreda J. The relationship between smoking and total immunoglobulin E levels. J Allergy Clin Immunol. 1982 Apr;69(4):370–375. doi: 10.1016/0091-6749(82)90148-8. [DOI] [PubMed] [Google Scholar]
  30. Weliky N., Heiner D. C. Hypersensitivity to chemicals. Correlation of tartrazine hypersensitivity with characteristic serum IgD and IgE immune response patterns. Clin Allergy. 1980 Jul;10(4):375–395. doi: 10.1111/j.1365-2222.1980.tb02121.x. [DOI] [PubMed] [Google Scholar]
  31. Whitehead R. H., Hooper B. E., Grimshaw D. A., Hughes L. E. Letter: Cellular immune responsiveness in cigarette smokers. Lancet. 1974 Jun 15;1(7868):1232–1233. doi: 10.1016/s0140-6736(74)91049-6. [DOI] [PubMed] [Google Scholar]
  32. Wingerd J., Sponzilli E. E. Concentrations of serum protein fractions in white women: effects of age, weight, smoking, tonsillectomy, and other factors;. Clin Chem. 1977 Jul;23(7):1310–1317. [PubMed] [Google Scholar]
  33. Zetterström O., Osterman K., Machado L., Johansson S. G. Another smoking hazard: raised serum IgE concentration and increased risk of occupational allergy. Br Med J (Clin Res Ed) 1981 Nov 7;283(6301):1215–1217. doi: 10.1136/bmj.283.6301.1215. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES