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. 1983 Mar;51(3):587–594.

Do food antigens play a role in the pathogenesis of some cases of human glomerulonephritis?

F J van der Woude, P J Hoedemaeker, M van der Giessen, P A de Graeff, J de Monchy, T H The, G K van der Hem
PMCID: PMC1536795  PMID: 6851247

Abstract

Circulating immune complexes after a test meal were measured with three methods (PEG precipitation, Clq-ELISA and the indirect granulocyte phagocytosis test) in 10 controls, two symptomless persons with selective IgA deficiency and 14 patients with various types of glomerulonephritis, of which two patients (with idiopathic membranous glomerulopathy and local focal glomerulonephritis) also had selective IgA deficiency. The PEG and Clq-ELISA test did not show significant differences between the groups. In the two symptomless persons with selective IgA deficiency and in the patient with local focal glomerulonephritis and selective IgA deficiency the indirect granulocyte phagocytosis test (IGFT) showed a reproducible increase in IgG, IgM and complement containing immune complexes. In the last patient multiple food antigens were probably responsible for this phenomenon, a rapid amelioration of kidney function could be induced three times by giving an antigen free diet.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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