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. 1982 Dec;50(3):507–514.

In vitro modulation of viral cell surface glycoproteins by anti-viral antibody in the presence of complement.

N T Gorman, P J Lachmann
PMCID: PMC1536822  PMID: 6762269

Abstract

In the presence of optimal concentrations of both anti-viral IgG and complement, cells persistently infected with either measles virus (DS6-PI) or canine distemper virus (CDV-PI) could be lysed. In contrast, in the presence of adequate concentrations of anti-viral IgG but no complement the viral antigens expressed on the cell surface of DS6-PI and CDV-PI cells were lost, i.e. the cells were modulated. It was however possible to show that with critical concentrations of anti-viral IgG but with only moderately depressed levels of complement, modulation of the cells rather than lysis could occur. The implication that this may have in the generation of persistent viral infections in vivo is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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