Abstract
The influence of cimetidine on skin graft rejection was studied in a well defined transplantation model of inbred mice. Four allogeneic transplantation combinations with increasing antigenic disparity and one xenograft combination were studied. Cimetidine (25 mg/kg body weight) was administered intraperitoneally at 8-hr intervals until rejection occurred. No differences in graft survival were observed between cimetidine-treated groups and saline-treated controls in any of the combinations studied.
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Selected References
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