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. 1980 Aug;41(2):303–308.

The placental transfer of IgG subclasses in human pregnancy.

R W Pitcher-Wilmott, P Hindocha, C B Wood
PMCID: PMC1537014  PMID: 7438556

Abstract

Total IgG concentrations and the concentrations of the four subclasses of IgG were estimated in thirty-four pairs of maternal and foetal sera from pregnancies of various gestations ranging from 28 to 42 weeks using the method of radial immunodiffusion. It was found that: (1) all subclasses of IgG cross the human placenta freely, (2) foetal levels of IgG and each subclass of IgG exceed maternal levels in full-term pregnancies and (3) there was a close linear relationship between gestational age and the placental transfer of IgG and each of its subclasses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allansmith M., McClellan B. H., Butterworth M., Maloney J. R. The development of immunoglobulin levels in man. J Pediatr. 1968 Feb;72(2):276–290. doi: 10.1016/s0022-3476(68)80324-5. [DOI] [PubMed] [Google Scholar]
  2. Dubowitz L. M., Dubowitz V., Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. doi: 10.1016/s0022-3476(70)80038-5. [DOI] [PubMed] [Google Scholar]
  3. GITLIN D., KUMATE J., URRUSTI J., MORALES C. THE SELECTIVITY OF THE HUMAN PLACENTA IN THE TRANSFER OF PLASMA PROTEINS FROM MOTHER TO FETUS. J Clin Invest. 1964 Oct;43:1938–1951. doi: 10.1172/JCI105068. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hay F. C., Hull M. G., Torrigiani G. The transfer of human IgG subclasses from mother to foetus. Clin Exp Immunol. 1971 Sep;9(3):355–358. [PMC free article] [PubMed] [Google Scholar]
  5. Hobbs J. R., Davis J. A. Serum gamma-G-globulin levels and gestational age in premature babies. Lancet. 1967 Apr 8;1(7493):757–759. doi: 10.1016/s0140-6736(67)91369-4. [DOI] [PubMed] [Google Scholar]
  6. Kohler P. F., Farr R. S. Elevation of cord over maternal IgG immunoglobulin: evidence for an active placental IgG transport. Nature. 1966 Jun 4;210(5040):1070–1071. doi: 10.1038/2101070a0. [DOI] [PubMed] [Google Scholar]
  7. LINNET-JEPSEN P., GALATIUS-JENSEN F., HAUGE M. On the inheritance of the Gm serum group. Acta Genet Stat Med. 1958;8(2):164–196. doi: 10.1159/000151065. [DOI] [PubMed] [Google Scholar]
  8. Lubchenco L. O., Hansman C., Boyd E. Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks. Pediatrics. 1966 Mar;37(3):403–408. [PubMed] [Google Scholar]
  9. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  10. Mellbye O. J., Natvig J. B. Presence and origin of human IgG subclass proteins in newborns. Vox Sang. 1973 Mar;24(3):206–215. doi: 10.1111/j.1423-0410.1973.tb02632.x. [DOI] [PubMed] [Google Scholar]
  11. Morell A., Skvaril F., Hitzig W. H., Barandun S. IgG subclasses: development of the serum concentrations in "normal" infants and children. J Pediatr. 1972 Jun;80(6):960–964. doi: 10.1016/s0022-3476(72)80007-6. [DOI] [PubMed] [Google Scholar]
  12. Morell A., Skvaril F., van Loghem E., Kleemola M. Human IgG subclasses in maternal and fetal serum. Vox Sang. 1971 Dec;21(6):481–492. doi: 10.1111/j.1423-0410.1971.tb04808.x. [DOI] [PubMed] [Google Scholar]
  13. Shakib F., Stanworth D. R., Drew R., Catty D. A quantitative study of the distribution of IgG sub-classes in a group of normal human sera. J Immunol Methods. 1975;8(1-2):17–28. doi: 10.1016/0022-1759(75)90077-0. [DOI] [PubMed] [Google Scholar]
  14. Virella G., De Pascale A., Lippi U. Placental transfer of a human IgG2 monocional protein. Experientia. 1971 Mar 15;27(3):324–325. doi: 10.1007/BF02138174. [DOI] [PubMed] [Google Scholar]
  15. Virella G., Silveira Nunes M. A., Tamagnini G. Placental transfer of human IgG subclasses. Clin Exp Immunol. 1972 Mar;10(3):475–478. [PMC free article] [PubMed] [Google Scholar]
  16. Wang A. C., Faulk W. P., Stuckey M. A., Fudenberg H. H. Chemical differences of adult, fetal and hypogammaglobulinemic IgG immunoglobulins. Immunochemistry. 1970 Aug;7(8):703–708. doi: 10.1016/0019-2791(70)90176-x. [DOI] [PubMed] [Google Scholar]
  17. Yeung C. Y., Hobbs J. R. Serum-gamma-G-globulin levels in normal premature, post-mature, and "small-for-dates" newborn babies. Lancet. 1968 Jun 1;1(7553):1167–1170. doi: 10.1016/s0140-6736(68)91865-5. [DOI] [PubMed] [Google Scholar]
  18. van Furth R., Schuit H. R., Hijmans W. The immunological development of the human fetus. J Exp Med. 1965 Dec 1;122(6):1173–1188. doi: 10.1084/jem.122.6.1173. [DOI] [PMC free article] [PubMed] [Google Scholar]

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