Abstract
Cell-mediated immunity is invariably impaired in protein-energy malnutrition. The effect of selected nutrient deficiencies on serum thymic factor activity was assessed in deprived rats and pair-fed controls. Deficits of calories, zinc or pyridoxine resulted in significant lowering of serum thymic factor activity whereas vitamin A deficiency did not have any effect. It is suggested that variants nutrients modulate different steps of cell-mediated immunity and that reduced thymic hormone activity may be the underlying mechanism of imparied immunity in some but not all nutritional deficiencies.
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Selected References
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- Bach J. F., Dardenne M. Studies on thymus products. II. Demonstration and characterization of a circulating thymic hormone. Immunology. 1973 Sep;25(3):353–366. [PMC free article] [PubMed] [Google Scholar]
- Chandra R. K., Au B. Single nutrient deficiency and cell-mediated immune responses. I. Zinc. Am J Clin Nutr. 1980 Apr;33(4):736–738. doi: 10.1093/ajcn/33.4.736. [DOI] [PubMed] [Google Scholar]
- Chandra R. K., Kutty K. M. Immunocompetence in obesity. Acta Paediatr Scand. 1980 Jan;69(1):25–30. doi: 10.1111/j.1651-2227.1980.tb07024.x. [DOI] [PubMed] [Google Scholar]
- Chandra R. K. Serum thymic hormone activity in protein-energy malnutrition. Clin Exp Immunol. 1979 Nov;38(2):228–230. [PMC free article] [PubMed] [Google Scholar]
- Chandra R. K. T and B lymphocyte subpopulations and leukocyte terminal deoxynucleotidyl-transferase in energy-protein undernutrition. Acta Paediatr Scand. 1979 Nov;68(6):841–845. doi: 10.1111/j.1651-2227.1979.tb08221.x. [DOI] [PubMed] [Google Scholar]
- Fernandes G., Nair M., Onoe K., Tanaka T., Floyd R., Good R. A. Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. Proc Natl Acad Sci U S A. 1979 Jan;76(1):457–461. doi: 10.1073/pnas.76.1.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fraker P. J., DePasquale-Jardieu P., Zwickl C. M., Luecke R. W. Regeneration of T-cell helper function in zinc-deficient adult mice. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5660–5664. doi: 10.1073/pnas.75.11.5660. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gross R. L., Osdin N., Fong L., Newberne P. M. I. Depressed immunological function in zinc-deprived rats as measured by mitogen response of spleen, thymus, and peripheral blood. Am J Clin Nutr. 1979 Jun;32(6):1260–1266. doi: 10.1093/ajcn/32.6.1260. [DOI] [PubMed] [Google Scholar]
- Iwata T., Incefy G. S., Tanaka T., Fernandes G., Menendez-Botet C. J., Pih K., Good R. A. Circulating thymic hormone levels in zinc deficiency. Cell Immunol. 1979 Sep 15;47(1):100–105. doi: 10.1016/0008-8749(79)90318-6. [DOI] [PubMed] [Google Scholar]
- Krishnan S., Bhuyan U. N., Talwar G. P., Ramalingaswami V. Effect of vitamin A and protein-calorie undernutrition on immune responses. Immunology. 1974 Sep;27(3):383–392. [PMC free article] [PubMed] [Google Scholar]
- Nauss K. M., Mark D. A., Suskind R. M. The effect of vitamin A deficiency on the in vitro cellular immune response of rats. J Nutr. 1979 Oct;109(10):1815–1823. doi: 10.1093/jn/109.10.1815. [DOI] [PubMed] [Google Scholar]
- Pekarek R. S., Sandstead H. H., Jacob R. A., Barcome D. F. Abnormal cellular immune responses during acquired zinc deficiency. Am J Clin Nutr. 1979 Jul;32(7):1466–1471. doi: 10.1093/ajcn/32.7.1466. [DOI] [PubMed] [Google Scholar]
- Robson L. C., Schwarz M. R. Vitamin B6 deficiency and the lymphoid system. I. Effects on cellular immunity and in vitro incorporation of 3H-uridine by small lymphocytes. Cell Immunol. 1975 Mar;16(1):135–144. doi: 10.1016/0008-8749(75)90192-6. [DOI] [PubMed] [Google Scholar]
- Willis-Carr J. I., St Pierre R. L. Effects of vitamin B6 deficiency on thymic epithelial cells and T lymphocyte differentiation. J Immunol. 1978 Apr;120(4):1153–1159. [PubMed] [Google Scholar]