Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1981 Jan;43(1):174–179.

T lymphocyte mobility: defects and effects of ascorbic acid, histamine and complexed IgG.

E M Smogorzewska, L Layward, J F Soothill
PMCID: PMC1537138  PMID: 6972838

Abstract

T lymphocyte mobility is low in patients with low neutrophil mobility. Thymocytes move comparably with normal mature T lymphocytes. Histamine accelerates T lymphocyte mobility in healthy subjects, patients with defective lymphocyte mobility and thymocytes. Ascorbic acid increases lymphocyte mobility of healthy subjects and thymocytes. Inhibition of mobility of T- or Tmu-depleted T lymphocytes by complexed IgG casts doubt on previous reports that the T gamma cells do not move.

Full text

PDF
174

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aggett P. J., Harries J. T., Harvey B. A., Soothill J. F. An inherited defect of neutrophil mobility in Shwachman syndrome. J Pediatr. 1979 Mar;94(3):391–394. doi: 10.1016/s0022-3476(79)80578-8. [DOI] [PubMed] [Google Scholar]
  2. Boxer L. A., Watanabe A. M., Rister M., Besch H. R., Jr, Allen J., Baehner R. L. Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate. N Engl J Med. 1976 Nov 4;295(19):1041–1045. doi: 10.1056/NEJM197611042951904. [DOI] [PubMed] [Google Scholar]
  3. De Cock W., De Cree J., Verhaegen H. Histamine receptor-bearing T lymphocytes in patients with allergy, autoimmune disease, or recurrent infection. Clin Immunol Immunopathol. 1978 Sep;11(1):1–5. doi: 10.1016/0090-1229(78)90198-8. [DOI] [PubMed] [Google Scholar]
  4. Earhoudi A., Harvey B. A., Soothill J. F. Clinicopathological findings in patients with primary and secondary defects of neutrophil mobility. Arch Dis Child. 1978 Aug;53(8):625–630. doi: 10.1136/adc.53.8.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gupta S., Kirkpatrick C. H., Good R. A. Subpopulations of human T lymphocytes. XI. T cells with receptors for IgM or IgG and locomotion of T and non-T cells in peripheral blood from patients with chronic mucocutaneous candidiasis. Clin Immunol Immunopathol. 1979 Sep;14(1):86–95. doi: 10.1016/0090-1229(79)90129-6. [DOI] [PubMed] [Google Scholar]
  6. Hayward A. R., Layward L., Lydyard P. M., Moretta L., Dagg M., Lawton A. R. Fc-receptor heterogeneity of human suppressor T cells. J Immunol. 1978 Jul;121(1):1–5. [PubMed] [Google Scholar]
  7. Hill H. R., Quie P. G. Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet. 1974 Feb 9;1(7850):183–187. doi: 10.1016/s0140-6736(74)92493-3. [DOI] [PubMed] [Google Scholar]
  8. Krabbe S., Skakkebaek N. E., Berthelsen J. G., Eyben F. V., Volsted P., Mauritzen K., Eldrup J., Nielsen A. H. High incidence of undetected neoplasia in maldescended testes. Lancet. 1979 May 12;1(8124):999–1000. doi: 10.1016/s0140-6736(79)92754-5. [DOI] [PubMed] [Google Scholar]
  9. O'Neill G. J., Parrott D. M. Locomotion of human lymphoid cells. I. Effect of culture and con A on T and non-T lymphocytes. Cell Immunol. 1977 Oct;33(2):257–267. doi: 10.1016/0008-8749(77)90156-3. [DOI] [PubMed] [Google Scholar]
  10. Parrott D. M., Good R. A., O'Neill G. J., Gupta S. Heterogeneity of locomotion in human T cell subsets. Proc Natl Acad Sci U S A. 1978 May;75(5):2392–2395. doi: 10.1073/pnas.75.5.2392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Schreiner G. F., Unanue E. R. Anti-Ig-triggered movements of lymphocytes-specificity and lack of evidence for directional migration. J Immunol. 1975 Feb;114(2 Pt 2):809–814. [PubMed] [Google Scholar]
  12. Shields J. M., Wilkinson P. C. Relations between Fc receptor function and locomotion in human lymphocytes. Clin Exp Immunol. 1979 Dec;38(3):598–608. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES