Abstract
Thymosin fraction V was submitted to the same purification procedure as used for the isolation of the circulating thymic factor (FTS) from pig serum: an FTS-like material was isolated from this fraction and shown to have similar activity, molecular weight, charge and amino acid composition as FTS. These data, together with previous experiments showing the binding of anti-FTS antibodies to reticulo-epithelial cells, provide a direct argument in favour of the presence of FTS in the thymus.
Full text
PDF





Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ahmed A., Wong D. M., Thurman G. B., Low T. L., Goldstein A. L., Sharkis S. J., Goldschneider I. T-lymphocyte maturation: cell surface markers and immune function induced by T-lymphocyte cell-free products and thymosin polypeptides. Ann N Y Acad Sci. 1979;332:81–94. doi: 10.1111/j.1749-6632.1979.tb47100.x. [DOI] [PubMed] [Google Scholar]
- Bach J. F., Dardenne M., Goldstein A. L., Guha A., White A. Appearance of T-cell markers in bone marrow rosette-forming cells after incubation with thymosin, a thymic hormone. Proc Natl Acad Sci U S A. 1971 Nov;68(11):2734–2738. doi: 10.1073/pnas.68.11.2734. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dardenne M., Pleau J. M., Man N. K., Bach J. F. Structural study of circulating thymic factor: a peptide isolated from pig serum. I. Isolation and purification. J Biol Chem. 1977 Nov 25;252(22):8040–8044. [PubMed] [Google Scholar]
- Hooper J. A., McDaniel M. C., Thurman G. B., Cohen G. H., Schulof R. S., Goldstein A. L. Purification and properties of bovine thymosin. Ann N Y Acad Sci. 1975 Feb 28;249:125–144. doi: 10.1111/j.1749-6632.1975.tb29063.x. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Low T. L., Thurman G. B., McAdoo M., McClure J., Rossio J. L., Naylor P. H., Goldstein A. L. The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymus. J Biol Chem. 1979 Feb 10;254(3):981–986. [PubMed] [Google Scholar]
- Monier J. C., Dardenne M., Pléau J. M., Schmitt D., Deschaux P., Bach J. F. Characterization of facteur thymique sérique (FTS) in the thymus. I. Fixation of anti-FTS antibodies on thymic reticulo-epithelial cells. Clin Exp Immunol. 1980 Dec;42(3):470–476. [PMC free article] [PubMed] [Google Scholar]