Abstract
Increased suppressor T gamma lymphocytes have been described in sarcoidosis. We have shown that a proportion of these cells are esterase-positive, phagocytic, adherent to plastic and stain with an anti-monocyte serum. Removal of these cells or the addition of indomethacin increases the lymphocyte transformation to Con A. Transformation was still reduced in spite of preincubation with plastic and the addition of indomethacin suggesting that a further abnormality exists. Thus, within the increased number of T gamma cells there exists a population of activated monocytes which rosette with sheep red blood cells and could therefore be mistaken for T cells.
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- Bockman R. S., Rothschild M. Prostaglandin E inhibition of T-lymphocyte colony formation: a possible mechanism of monocyte modulation of clonal expansion. J Clin Invest. 1979 Sep;64(3):812–819. doi: 10.1172/JCI109528. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Faguet G. B. Cellular immunity in sarcoidosis: evidence for an intrinsic defect of effector cell function. Am Rev Respir Dis. 1978 Jul;118(1):89–96. doi: 10.1164/arrd.1978.118.1.89. [DOI] [PubMed] [Google Scholar]
- Goodwin J. S., DeHoratius R., Israel H., Peake G. T., Messner R. P. Suppressor cell function in sarcoidosis. Ann Intern Med. 1979 Feb;90(2):169–173. doi: 10.7326/0003-4819-90-2-169. [DOI] [PubMed] [Google Scholar]
- Haegert D. G. Phagocytic peripheral blood monocytes from rabbits and humans express membrane receptors specific for IgM molecules: evidence that incubation with neuraminidase exposes cryptic IgM (Fc) receptors. Clin Exp Immunol. 1979 Mar;35(3):484–490. [PMC free article] [PubMed] [Google Scholar]
- Hayward A. R., Lydyard P. M. Suppression of B lymphocyte differentiation by newborn T lymphocytes with an Fc receptor for IgM. Clin Exp Immunol. 1978 Dec;34(3):374–378. [PMC free article] [PubMed] [Google Scholar]
- Hedfors E., Holm G., Pettersson D. Lymphocyte subpopulations in sarcoidosis. Clin Exp Immunol. 1974 Jun;17(2):219–226. [PMC free article] [PubMed] [Google Scholar]
- Katz P., Haynes B. F., Fauci A. S. Alteration of T-lymphocyte subpopulations in sarcoidosis. Clin Immunol Immunopathol. 1978 Jul;10(3):350–354. doi: 10.1016/0090-1229(78)90192-7. [DOI] [PubMed] [Google Scholar]
- Moretta L., Ferrarini M., Mingari M. C., Moretta A., Webb S. R. Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness. J Immunol. 1976 Dec;117(6):2171–2174. [PubMed] [Google Scholar]
- Roberts M. M., Greaves M. F. Maturation linked expression of a myeloid cell surface antigen. Br J Haematol. 1978 Apr;38(4):439–452. doi: 10.1111/j.1365-2141.1978.tb01069.x. [DOI] [PubMed] [Google Scholar]