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. 1981 Apr;44(1):11–17.

The effects of nandrolone, testosterone and their decanoate esters on murine lupus.

H A Verheul, W H Stimson, F C den Hollander, A H Schuurs
PMCID: PMC1537214  PMID: 6973425

Abstract

Treatment of NZB/NZW F1 (B/W) female and castrated male mice with testosterone or 19-nortestosterone (nandrolone), either by implantation in silastic tubing or by subcutaneous injections of their decanoate esters, reduced in a dose-dependent manner symptoms associated with murine lupus (proteinuria, IgG antibodies to DNA) and prolonged survival. These phenomena were observed under both prophylactic (start at 3-4 weeks) and therapeutic treatments (start 27-29 weeks). Nandrolone and its decanoate ester were at least as potent as testosterone and testosterone decanoate. As the unwanted androgenic properties of nandrolone and its ester are significantly less pronounced than those of testosterone and its ester, also in these NZB/NZW mice, the beneficial effect on murine lupus does not seem to be associated with these properties.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. HERSHBERGER L. G., SHIPLEY E. G., MEYER R. K. Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method. Proc Soc Exp Biol Med. 1953 May;83(1):175–180. doi: 10.3181/00379727-83-20301. [DOI] [PubMed] [Google Scholar]
  2. Hancock K., Peet B. G., Price J. J., Watson G. W., Stone J., Turner R. L. Ten-year survival rates in breast cancer using combination chemotherapy. Br J Surg. 1977 Feb;64(2):134–138. doi: 10.1002/bjs.1800640213. [DOI] [PubMed] [Google Scholar]
  3. Howie J. B., Helyer B. J. The immunology and pathology of NZB mice. Adv Immunol. 1968;9:215–266. doi: 10.1016/s0065-2776(08)60444-7. [DOI] [PubMed] [Google Scholar]
  4. Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Levy J. A. Autoimmunity and neoplasia. The possible role of C-type viruses. Am J Clin Pathol. 1974 Aug;62(2):258–280. doi: 10.1093/ajcp/62.2.258. [DOI] [PubMed] [Google Scholar]
  6. Melez K. A., Boegel W. A., Steinberg A. D. Therapeutic studies in New Zealand mice. VII. Successful androgen treatment of NZB/NZW F1 females of different ages. Arthritis Rheum. 1980 Jan;23(1):41–47. doi: 10.1002/art.1780230108. [DOI] [PubMed] [Google Scholar]
  7. Melez K. A., Reeves J. P., Steinberg A. D. Regulation of the expression of autoimmunity in NZB x NZW F1 mice by sex hormones. J Immunopharmacol. 1978 1979;1(1):27–42. doi: 10.3109/08923977809027328. [DOI] [PubMed] [Google Scholar]
  8. OVERBEEK G. A., de VISSER A comparison of the myotrophic and androgenic activities of the phenylpropionates and decanoates of testosterone and nandrolone. Acta Endocrinol (Copenh) 1961 Oct;38:285–292. doi: 10.1530/acta.0.0380285. [DOI] [PubMed] [Google Scholar]
  9. Roubinian J. R., Papoian R., Talal N. Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest. 1977 Jun;59(6):1066–1070. doi: 10.1172/JCI108729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Nussenzweig V. Danazol's failure to suppress autoimmunity in NZB/NZW F1 mice. Arthritis Rheum. 1979 Dec;22(12):1399–1402. doi: 10.1002/art.1780221215. [DOI] [PubMed] [Google Scholar]
  11. Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Delayed androgen treatment prolongs survival in murine lupus. J Clin Invest. 1979 May;63(5):902–911. doi: 10.1172/JCI109390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978 Jun 1;147(6):1568–1583. doi: 10.1084/jem.147.6.1568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Roubinian J., Talal N., Siiteri P. K., Sadakian J. A. Sex hormone modulation of autoimmunity in NZB/NZW mice. Arthritis Rheum. 1979 Nov;22(11):1162–1169. doi: 10.1002/art.1780221102. [DOI] [PubMed] [Google Scholar]
  14. Steinberg A. D., Melez K. A., Raveche E. S., Reeves J. P., Boegel W. A., Smathers P. A., Taurog J. D., Weinlein L., Duvic M. Approach to the study of the role of sex hormones in autoimmunity. Arthritis Rheum. 1979 Nov;22(11):1170–1176. doi: 10.1002/art.1780221103. [DOI] [PubMed] [Google Scholar]
  15. Talal N. Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus. Arthritis Rheum. 1970 Nov-Dec;13(6):887–894. doi: 10.1002/art.1780130620. [DOI] [PubMed] [Google Scholar]

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