Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1981 Jul;45(1):152–157.

Role of macrophages in T lymphocyte response to Candida allergen in man with special reference to HLA-D and DR.

Y Nose, K Komori, H Inouye, K Nomura, M Yamamura, K Tsuji
PMCID: PMC1537241  PMID: 7030536

Abstract

Activation of naturally sensitized human T lymphocytes to Candida allergen was studied using three HLA-D and DR heterozygote Japanese cells (Dw1.DR1/DYT.DR4, Dw12.DR2/DYT.DR4, DYT.DR4/DEn.DR blank) and four HLA-D and DR homozygote cells (Dw1.DR1, Dw12.DR2, DYT.DR4, DEn.DR blank). In vitro activation of T lymphocytes to Candida allergen was found to require the presence of autologous or allogeneic compatible HLA-Dw1.DR1 and Dw12.DR2 macrophages.

Full text

PDF
152

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOYUM A. SEPARATION OF WHITE BLOOD CELLS. Nature. 1964 Nov 21;204:793–794. doi: 10.1038/204793a0. [DOI] [PubMed] [Google Scholar]
  2. Bergholtz B. O., Thorsby E. HLA-D-restricted antigen activation of sensitized T lymphocytes: studies on the ability of HLA-D/DR-expressing B lymphocytes to substitute for macrophages in antigen activation. Scand J Immunol. 1979;10(3):267–274. doi: 10.1111/j.1365-3083.1979.tb01349.x. [DOI] [PubMed] [Google Scholar]
  3. Bergholtz B. O., Thorsby E. Macrophage-dependent response of immune human T lymphocytes to PPD in vitro. Influence of HLA-D histocompatibility. Scand J Immunol. 1977;6(8):779–786. doi: 10.1111/j.1365-3083.1977.tb02151.x. [DOI] [PubMed] [Google Scholar]
  4. Greenberg L. J., Gray E. D., Yunis E. J. Association of HL-A 5 and immune responsiveness in vitro to streptococcal antigens. J Exp Med. 1975 May 1;141(5):935–943. doi: 10.1084/jem.141.5.935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Nose Y., Komori K., Inouye H., Nomura K., Yamamura M., Tsuji K. Relationship between HLA-D and in vitro and in vivo responsiveness to Candida allergen. Clin Exp Immunol. 1980 May;40(2):345–350. [PMC free article] [PubMed] [Google Scholar]
  6. Paul W. E., Benacerraf B. Functional specificity of thymus- dependent lymphocytes. Science. 1977 Mar 25;195(4284):1293–1300. doi: 10.1126/science.320663. [DOI] [PubMed] [Google Scholar]
  7. Sasazuki T., Kohno Y., Iwamoto I., Tanimura M., Naito S. Association between an HLA haplotype and low responsiveness to tetanus toxoid in man. Nature. 1978 Mar 23;272(5651):359–361. doi: 10.1038/272359b0. [DOI] [PubMed] [Google Scholar]
  8. Tsuji K., Nose Y., Komori K., Shiwaku Y., Inouye H. The relationship between HLA-D and DR antigens in four Japanese HTCs. Transplant Proc. 1978 Dec;10(4):797–798. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES