Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1981 Feb;43(2):276–284.

The human cytotoxic T cell response to influenza A vaccination.

A J McMichael, F Gotch, P Cullen, B Askonas, R G Webster
PMCID: PMC1537292  PMID: 6974066

Abstract

The human cytotoxic T lymphocyte (CTL) response to challenge with influenza A vaccine was studied. Six of eight volunteers given killed whole influenza virus A/USSR (H1N1) vaccine showed substantial increases on the level of CTL memory 1 month after immunization. The CTL measured at this time showed complete cross-reactivity in their specificity for influenza A/USSR (H1N1) and A/X31 (H3N2) infected cells and also showed HLA restriction. The level of CTL memory increased in only three out of nine donors given subunit vaccine and showed no change in those not given vaccine. If cytotoxic T cells are important in influenza prophylaxis, killed whole virus vaccine should offer better protection than subunit vaccine.

Full text

PDF
276

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashman R. B., Müllbacher A. A T helper cell for anti-viral cytotoxic T-cell responses. J Exp Med. 1979 Nov 1;150(5):1277–1282. doi: 10.1084/jem.150.5.1277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Biddison W. E., Shaw S., Nelson D. L. Virus specificity of human influenza virus-immune cytotoxic T cells. J Immunol. 1979 Feb;122(2):660–664. [PubMed] [Google Scholar]
  3. Braciale T. J. Immunologic recognition of influenza virus-infected cells. I. Generation of a virus-strain specific and a cross-reactive subpopulation of cytotoxic T cells in the response to type A influenza viruses of different subtypes. Cell Immunol. 1977 Oct;33(2):423–436. doi: 10.1016/0008-8749(77)90170-8. [DOI] [PubMed] [Google Scholar]
  4. Ennis F. A., Martin W. J., Verbonitz M. W. Hemagglutinin-specific cytotoxic T-cell response during influenza infection. J Exp Med. 1977 Sep 1;146(3):893–898. doi: 10.1084/jem.146.3.893. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hoskins T. W., Davies J. R., Smith A. J., Allchin A., Miller C. L., Pollock T. M. Influenza at Christ's Hospital: March, 1974. Lancet. 1976 Jan 17;1(7951):105–108. doi: 10.1016/s0140-6736(76)93151-2. [DOI] [PubMed] [Google Scholar]
  6. McMichael A. J., Askonas B. A. Influenza virus-specific cytotoxic T cells in man; induction and properties of the cytotoxic cell. Eur J Immunol. 1978 Oct;8(10):705–711. doi: 10.1002/eji.1830081007. [DOI] [PubMed] [Google Scholar]
  7. McMichael A. HLA restriction of human cytotoxic T lymphocytes specific for influenza virus. Poor recognition of virus associated with HLA A2. J Exp Med. 1978 Dec 1;148(6):1458–1467. doi: 10.1084/jem.148.6.1458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Meiklejohn G., Eickhoff T. C., Graves P., I J. Antigenic drift and efficacy of influenza virus vaccines, 1976--1977. J Infect Dis. 1978 Nov;138(5):618–624. doi: 10.1093/infdis/138.5.618. [DOI] [PubMed] [Google Scholar]
  9. Pereira M. S. The effects of shifts and drifts on the epidemiology of influenza in man. Philos Trans R Soc Lond B Biol Sci. 1980 Feb 25;288(1029):423–432. doi: 10.1098/rstb.1980.0019. [DOI] [PubMed] [Google Scholar]
  10. Schoenbaum S. C., Mostow S. R., Dowdle W. R., Coleman M. T., Kaye H. S. Studies with inactivated influenza vaccines purified by zonal centrifugation. 2. Efficacy. Bull World Health Organ. 1969;41(3):531–535. [PMC free article] [PubMed] [Google Scholar]
  11. Shaw S., Biddison W. E. HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus. J Exp Med. 1979 Mar 1;149(3):565–575. doi: 10.1084/jem.149.3.565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Webster R. G., Askonas B. A. Cross-protection and cross-reactive cytotoxic T cells induced by influenza virus vaccines in mice. Eur J Immunol. 1980 May;10(5):396–401. doi: 10.1002/eji.1830100515. [DOI] [PubMed] [Google Scholar]
  13. Yap K. L., Ada G. L. Cytotoxic T cells in the lungs of mice infected with an influenza A virus. Scand J Immunol. 1978;7(1):73–80. doi: 10.1111/j.1365-3083.1978.tb00428.x. [DOI] [PubMed] [Google Scholar]
  14. Yap K. L., Ada G. L., McKenzie I. F. Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature. 1978 May 18;273(5659):238–239. doi: 10.1038/273238a0. [DOI] [PubMed] [Google Scholar]
  15. Zweerink H. J., Courtneidge S. A., Skehel J. J., Crumpton M. J., Askonas B. A. Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses. Nature. 1977 May 26;267(5609):354–356. doi: 10.1038/267354a0. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES